Publications by authors named "Matthias Gstaiger"

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Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL-ML Hit.
Lasse Hoffmann, Christopher Lenz, Frederic Farges, Serah W Kimani, Johannes Dopfer, Matthias Gstaiger

RSC Chem Biol· October 2025

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Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor.
Sebastian Mandel, Thomas Hanke, Niall Prendiville, María Baena-Nuevo, Lena Marie Berger, Matthias Gstaiger

J Med Chem· July 2025

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A tissue-specific atlas of protein-protein associations enables prioritization of candidate disease genes.
Diederik S Laman Trip, Marc van Oostrum, Danish Memon, Fabian Frommelt, Delora Baptista, Matthias Gstaiger

Nat Biotechnol· May 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock, Matthias Gstaiger

RSC Med Chem· February 2025

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Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.
Lukas Bissegger, Theodora A Constantin, Erhan Keles, Luka Raguž, Isobel Barlow-Busch, Matthias Gstaiger

Chem Sci· December 2024

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A chemical probe to modulate human GID4 Pro/N-degron interactions.
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Matthias Gstaiger

Nat Chem Biol· September 2024

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DIP-MS: ultra-deep interaction proteomics for the deconvolution of protein complexes.
Fabian Frommelt, Andrea Fossati, Federico Uliana, Fabian Wendt, Peng Xue, Matthias Gstaiger

Nat Methods· April 2024

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Harnessing CD3 diversity to optimize CAR T cells.
Rubí M-H Velasco Cárdenas, Simon M Brandl, Ana Valeria Meléndez, Alexandra Emilia Schlaak, Annabelle Buschky, Matthias Gstaiger

Nat Immunol· December 2023

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Target Deconvolution by Limited Proteolysis Coupled to Mass Spectrometry.
Viviane Reber, Matthias Gstaiger

Methods Mol Biol· August 2023

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Phosphorylation-linked complex profiling identifies assemblies required for Hippo signal integration.
Federico Uliana, Rodolfo Ciuffa, Ranjan Mishra, Andrea Fossati, Fabian Frommelt, Matthias Gstaiger

Mol Syst Biol· April 2023

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Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
Rodolfo Ciuffa, Federico Uliana, Jonathan Mannion, Martin Mehnert, Tencho Tenev, Matthias Gstaiger

Proc Natl Acad Sci U S A· October 2022

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Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.
Chiara Borsari, Erhan Keles, Jacob A McPhail, Alexander Schaefer, Rohitha Sriramaratnam, Matthias Gstaiger

J Am Chem Soc· April 2022

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PCprophet: a framework for protein complex prediction and differential analysis using proteomic data.
Andrea Fossati, Chen Li, Federico Uliana, Fabian Wendt, Fabian Frommelt, Matthias Gstaiger

Nat Methods· May 2021

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System-Wide Profiling of Protein Complexes Via Size Exclusion Chromatography-Mass Spectrometry (SEC-MS).
Andrea Fossati, Fabian Frommelt, Federico Uliana, Claudia Martelli, Matej Vizovisek, Matthias Gstaiger

Methods Mol Biol· April 2021

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Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma.
Alexander Schäfer, Benedicte Haenig, Julie Erupathil, Panja Strickner, Daniela Sabato, Matthias Gstaiger

Oncogene· March 2021

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Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen.
Federico Uliana, Matej Vizovišek, Laura Acquasaliente, Rodolfo Ciuffa, Andrea Fossati, Matthias Gstaiger

Nat Commun· March 2021

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Complex-centric proteome profiling by SEC-SWATH-MS for the parallel detection of hundreds of protein complexes.
Isabell Bludau, Moritz Heusel, Max Frank, George Rosenberger, Robin Hafen, Matthias Gstaiger

Nat Protoc· August 2020

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Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, Matthias Gstaiger

Mol Cell· August 2020

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NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.
Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Matthias Gstaiger

Elife· August 2020

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Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes.
Martin Mehnert, Rodolfo Ciuffa, Fabian Frommelt, Federico Uliana, Audrey van Drogen, Matthias Gstaiger

Nat Commun· July 2020

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A Global Screen for Assembly State Changes of the Mitotic Proteome by SEC-SWATH-MS.
Moritz Heusel, Max Frank, Mario Köhler, Sabine Amon, Fabian Frommelt, Matthias Gstaiger

Cell Syst· February 2020

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The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.
Yun Huang, Brice Mouttet, Hans-Jörg Warnatz, Thomas Risch, Fabian Rietmann, Matthias Gstaiger

Cancer Cell· December 2019

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Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data.
Alexander Schäfer, Enio Gjerga, Richard Wd Welford, Imke Renz, Francois Lehembre, Matthias Gstaiger

Mol Syst Biol· August 2019

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Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy.
Javier Celis-Gutierrez, Peter Blattmann, Yunhao Zhai, Nicolas Jarmuzynski, Kilian Ruminski, Matthias Gstaiger

Cell Rep· June 2019

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BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly.
Lukas Frischknecht, Christian Britschgi, Patricia Galliker, Yann Christinat, Anton Vichalkovski, Matthias Gstaiger

Sci Rep· May 2019

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