Publications by authors named "Michael Chlenov"

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Normal-phase automated mass-directed HPLC purification of a pyrrolobenzodiazepine library with vasopressin agonist activity.
Michael Kagan, Michael Chlenov, Sergey Melnikov, Oliver McConnell, Alvin C Bach

J Comb Chem· October 2010

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Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.
Zhongqi Shen, P Siva Ramamoorthy, Nicole T Hatzenbuhler, Deborah A Evrard, Wayne Childers, Michael Chlenov

Bioorg Med Chem Lett· January 2010

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Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Scott C Mayer, Anthony F Kreft, Boyd Harrison, Magid Abou-Gharbia, Madelene Antane, Michael Chlenov

J Med Chem· December 2008

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Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.
Nicole T Hatzenbuhler, Reinhardt Baudy, Deborah A Evrard, Amedeo Failli, Boyd L Harrison, Michael Chlenov

J Med Chem· November 2008

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Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery: building chiral technology toolboxes.
Oliver McConnell, Alvin Bach, Carl Balibar, Neal Byrne, Yanxuan Cai, Michael Chlenov

Chirality· September 2007

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Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor.
Dahui Zhou, Nicole T Hatzenbuhler, Jonathan L Gross, Boyd L Harrison, Deborah A Evrard, Michael Chlenov

Bioorg Med Chem Lett· June 2007

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Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC. A simple model for predicting blood-brain distribution.
Nellie Gulyaeva, Alexander Zaslavsky, Pamela Lechner, Michael Chlenov, Oliver McConnell

Eur J Med Chem· April 2003

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Relative hydrophobicity and lipophilicity of beta-blockers and related compounds as measured by aqueous two-phase partitioning, octanol-buffer partitioning, and HPLC.
Nellie Gulyaeva, Alexander Zaslavsky, Pamela Lechner, Michael Chlenov, Arnon Chait

Eur J Pharm Sci· October 2002

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Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.
Hassan M Elokdah, Gregory S Friedrichs, Sie Yearl Chai, Boyd L Harrison, John Primeau, Michael Chlenov

Bioorg Med Chem Lett· August 2002

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