Publications by authors named "Wayne Childers"

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Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity.
Minjeong Yeon, Michela Perego, Khaled M Elokely, Magid Abou-Gharbia, Wayne E Childers

Cancer Res· December 2025

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MC-100093, a synthetic beta-lactam compound, and ceftriaxone modulate nicotine consumption, neuroinflammation and glutamatergic transporters in a nicotine self-administration mouse model.
Jawaher A Alotaibi, Fawaz Alasmari, Awatif B Albaker, Fatin A Alrashedi, Mohamed Mohany, Wayne E Childers

Psychopharmacology (Berl)· December 2025

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Modulatory effects of GLT-1 enhancer, MC-100093, on glutamate uptake and associated signaling pathways in female and male alcohol preferring rats exposed to ethanol.
Ahmed Alotaibi, Khokon Kanti Bhowmik, Woonyen Wong, Adil Shareef Mohammed, Magid Abou-Gharbia, Wayne Childers

Int J Neuropsychopharmacol· November 2025

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RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors.
Gurushankar Chandramouly, William Fried, John Gordon, Douglas Ralph, Channita Keuk, Wayne E Childers

J Med Chem· November 2025

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Differential Modulation of Glutamate Transporter-1 by Cocaine and Oxycodone and the Efficacy of MC-100093 to Reduce Reinstatement of Self-Administration.
Damyan W Hart, Yanaira Alonso-Caraballo, Britta Hornback, Angel Robert, Megan A Brickner, Wayne E Childers

Brain Behav· July 2025

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DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition.
V S S Abhinav Ayyadevara, Gerald Wertheim, Shikha Gaur, John A Chukinas, Joseph P Loftus, Wayne Childers

Leukemia· May 2025

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Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition.
Xiaotian Zhang, Heykyeong Jeong, Jingwen Niu, Sabrina M Holland, Brittany N Rotanz, Wayne E Childers

Nat Commun· April 2025

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ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination.
Huan Li, Srinivas Chatla, Xiaolei Liu, Zhen Tian, Umeshkumar Vekariya, Wayne Childers

Cancer Lett· March 2025

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Mechanistic studies on pH-permeability relationships: Impact of the membrane polar headgroup region on pKa.
Md Hridoy, Irfan Khan, Mercy Ramanjulu, Paul Anthony, Wayne Childers

Int J Pharm· March 2025

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Dezocine and Addiction: Friend or Foe?
Wayne Childers, Khaled Elokely, Magid Abou-Gharbia

Pharmaceuticals (Basel)· March 2025

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First Demonstration of PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders.
Shams Ul Mahmood, Jeremy Eberhard, Charles S Hoffman, Dennis Colussi, John Gordon, Wayne Childers

J Med Chem· October 2024

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Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms.
Abdullah F AlAsmari, Mohammed M Alshehri, Nemat Ali, Fawaz AlAsmari, Youssef Sari, Wayne E Childers

Saudi Pharm J· September 2024

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Effects of MC-100093 on Ethanol Drinking and the Expression of Astrocytic Glutamate Transporters in the Mesocorticolimbic Brain Regions of Male and Female Alcohol-Preferring Rats.
Ahmed Alotaibi, Shelby Travaglianti, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers

Neuroscience· August 2024

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Neuroinflammation and Neurometabolomic Profiling in Fentanyl Overdose Mouse Model Treated with Novel β-Lactam, MC-100093, and Ceftriaxone.
Mohammed S Alasmari, Fawaz Alasmari, Shakir D Alsharari, Abdullah F Alasmari, Nemat Ali, Wayne E Childers

Toxics· August 2024

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Effects of novel beta-lactam, MC-100093, and ceftriaxone on astrocytic glutamate transporters and neuroinflammatory factors in nucleus accumbens of C57BL/6 mice exposed to escalated doses of morphine.
Youssef Sari, Ghadeer M S Swiss, Fatin A Alrashedi, Kholoud A Baeshen, Sultan A Alshammari, Wayne E Childers

Saudi Pharm J· July 2024

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Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials".
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Wayne E Childers

J Med Chem· July 2024

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Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol.
Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers

Brain Res Bull· June 2024

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4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Marissa L Calbert, Gurushankar Chandramouly, Clare M Adams, Magali Saez-Ayala, Tatiana Kent, Wayne E Childers

Mol Cancer Ther· May 2024

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Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Wayne Childers

Nat Commun· April 2024

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Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition.
Xiaotian Zhang, Heykyeong Jeong, Jingwen Niu, Sabrina M Holland, Brittany N Rotanz, Wayne E Childers

bioRxiv· April 2024

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Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
John A Gilleran, Kutub Ashraf, Melvin Delvillar, Tyler Eck, Raheel Fondekar, Wayne E Childers

J Med Chem· March 2024

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MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer.
Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers

Clin Epigenetics· January 2024

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First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.
Shams Ul Mahmood, Mariana Lozano Gonzalez, Sreedhar Tummalapalli, Jeremy Eberhard, Judy Ly, Wayne Childers

J Med Chem· November 2023

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Liver Metabolomics and Inflammatory Profiles in Mouse Model of Fentanyl Overdose Treated with Beta-Lactams.
Fawaz Alasmari, Mohammed S Alasmari, Mohammed A Assiri, Mohammed Alswayyed, Syed Rizwan Ahamad, Wayne E Childers

Metabolites· August 2023

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Haploinsufficiency of ZNF251 causes DNA-PKcs-dependent resistance to PARP inhibitors in BRCA1-mutated cancer cells.
Huan Li, Srinivas Chatla, Xiaolei Liu, Umeshkumar Vekariya, Dongwook Kim, Wayne Childers

Res Sq· April 2023

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