Publications by authors named "Michael Croghan"

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
Lewis D Pennington, Michael D Bartberger, Michael D Croghan, Kristin L Andrews, Kate S Ashton

J Med Chem· December 2015

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
Kate S Ashton, Kristin L Andrews, Marian C Bryan, Jie Chen, Kui Chen, Michael Croghan

J Med Chem· January 2014

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Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.
Matthew M Weiss, Toni Williamson, Safura Babu-Khan, Michael D Bartberger, James Brown, Michael D Croghan

J Med Chem· November 2012

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Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Thomas A Dineen, Matthew M Weiss, Toni Williamson, Paul Acton, Safura Babu-Khan, Michael D Croghan

J Med Chem· November 2012

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.
Matthew R Kaller, Scott S Harried, Brian Albrecht, Patricia Amarante, Safura Babu-Khan, Michael D Croghan

ACS Med Chem Lett· November 2012

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Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.
Lewis D Pennington, Michael D Croghan, Kelvin K C Sham, Alexander J Pickrell, Paul E Harrington

Bioorg Med Chem Lett· January 2012

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Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.
Paul E Harrington, Michael D Croghan, Christopher Fotsch, Mike Frohn, Brian A Lanman

ACS Med Chem Lett· January 2012

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4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.
Lewis D Pennington, Kelvin K C Sham, Alexander J Pickrell, Paul E Harrington, Michael J Frohn, Michael D Croghan

ACS Med Chem Lett· October 2011

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The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.
Paul E Harrington, David J St Jean, Jeffrey Clarine, Thomas S Coulter, Michael Croghan

Bioorg Med Chem Lett· September 2010

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Stereoselective synthesis of anti-N-protected 3-amino-1,2-epoxides by nucleophilic addition to N-tert-butanesulfinyl imine of a glyceraldehyde synthon.
Scott S Harried, Michael D Croghan, Matthew R Kaller, Patricia Lopez, Wenge Zhong

J Org Chem· August 2009

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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).
Christopher Fotsch, Duncan M Smith, Jeffrey A Adams, Janet Cheetham, Michael Croghan

Bioorg Med Chem Lett· July 2003

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