Publications by authors named "Michael D Briggs"

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From Protein Misfolding to Extracellular Matrix Disorganisation: Understanding Disease Pathology in Rare Skeletal Dysplasias.
Ella Patricia Dennis, Michael Darren Briggs

Int J Mol Sci· October 2025

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Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3.
Ella P Dennis, Robyn N Watson, Florence McPate, Michael D Briggs

Int J Mol Sci· January 2023

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CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation.
Adam Duxfield, Jennifer Munkley, Michael D Briggs, Ella P Dennis

Sci Rep· August 2022

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Increased hippocampal excitability in miR-324-null mice.
Dan J Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Michael D Briggs

Sci Rep· May 2021

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Multiple epiphyseal dysplasia and related disorders: Molecular genetics, disease mechanisms, and therapeutic avenues.
Ella P Dennis, Phillippa L Greenhalgh-Maychell, Michael D Briggs

Dev Dyn· March 2021

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CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development.
Ella P Dennis, Sarah M Edwards, Robert M Jackson, Claire L Hartley, Dimitra Tsompani, Michael D Briggs

J Bone Miner Res· August 2020

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New developments in chondrocyte ER stress and related diseases.
Michael D Briggs, Ella P Dennis, Helen F Dietmar, Katarzyna A Pirog

F1000Res· July 2020

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Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis.
Louise H W Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, Michael D Briggs

Arthritis Res Ther· September 2019

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XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease.
Katarzyna A Piróg, Ella P Dennis, Claire L Hartley, Robert M Jackson, Jamie Soul, Michael D Briggs

PLoS Genet· July 2019

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Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.
Lorna A Mullan, Ewa J Mularczyk, Louise H Kung, Mitra Forouhan, Jordan Ma Wragg, Michael D Briggs

J Clin Invest· October 2017

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The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases.
Beth G Gibson, Michael D Briggs

Orphanet J Rare Dis· June 2016

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Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth.
Louise H W Kung, M Helen Rajpar, Richard Preziosi, Michael D Briggs, Raymond P Boot-Handford

PLoS One· November 2015

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New therapeutic targets in rare genetic skeletal diseases.
Michael D Briggs, Peter A Bell, Michael J Wright, Katarzyna A Pirog

Expert Opin Orphan Drugs· October 2015

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The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review).
Michael D Briggs, Peter A Bell, Katarzyna A Pirog

Int J Mol Med· June 2015

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Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia.
Katarzyna A Piróg, Andreja Irman, Siobhan Young, Poonam Halai, Peter A Bell, Michael D Briggs

PLoS One· January 2015

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Genotype to phenotype correlations in cartilage oligomeric matrix protein associated chondrodysplasias.
Michael D Briggs, Joanne Brock, Simon C Ramsden, Peter A Bell

Eur J Hum Genet· November 2014

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Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases.
Katarzyna A Piróg, Yoshihisa Katakura, Aleksandr Mironov, Michael D Briggs

PLoS One· August 2014

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Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.
Claire L Hartley, Sarah Edwards, Lorna Mullan, Peter A Bell, Maryline Fresquet, Michael D Briggs

Hum Mol Genet· December 2013

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A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.
Benedetta Gualeni, M Helen Rajpar, Aaron Kellogg, Peter A Bell, Peter Arvan, Michael D Briggs

Dis Model Mech· November 2013

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Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures.
Peter A Bell, Raimund Wagener, Frank Zaucke, Manuel Koch, Julian Selley, Michael D Briggs

Biol Open· August 2013

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Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response.
Louise H W Kung, M Helen Rajpar, Michael D Briggs, Raymond P Boot-Handford

J Histochem Cytochem· October 2012

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Collagen XXVII organises the pericellular matrix in the growth plate.
Darren A Plumb, Laila Ferrara, Tanja Torbica, Lynnette Knowles, Aleksandr Mironov, Michael D Briggs

PLoS One· April 2012

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Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.
Eric D Boyden, A Belinda Campos-Xavier, Sebastian Kalamajski, Trevor L Cameron, Philippe Suarez, Michael D Briggs

Am J Hum Genet· December 2011

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