Publications by authors named "Michael D Kaytor"

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Prophylactic Administration of BIO 300, A Radiation Medical Countermeasure, Improves Erythrocyte-Associated Parameters in the Rhesus Macaque Model.
Oluseyi O Fatanmi, Stephen Y Wise, Sarah A Petrus, Issa Melendez-Miranda, Alana D Carpenter, Michael D Kaytor

Mil Med· September 2025

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Lethality Assessments for Acutely Irradiated Cynomolgus Macaques Under Subject-based Care.
Issa Melendez-Miranda, Oluseyi O Fatanmi, Stephen Y Wise, Sarah A Petrus, Alana D Carpenter, Michael D Kaytor

Radiat Res· May 2025

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BIO 300: A Prophylactic Radiation Countermeasure for Acute Radiation Syndrome.
Vijay K Singh, Artur A Serebrenik, Stephen Y Wise, Sarah A Petrus, Oluseyi O Fatanmi, Michael D Kaytor

Mil Med· August 2024

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BIO 300 Attenuates Whole Blood Transcriptome Changes in Mice Exposed to Total-Body Radiation.
Artur A Serebrenik, Oluseyi O Fatanmi, Stephen Y Wise, Sarah A Petrus, Michael D Kaytor

Int J Mol Sci· August 2024

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Multicenter Phase 1b/2a Clinical Trial of Radioprotectant BIO 300 Oral Suspension for Patients With Non-Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy.
Charles B Simone, Artur A Serebrenik, Elizabeth M Gore, Pranshu Mohindra, Stephen L Brown, Michael D Kaytor

Int J Radiat Oncol Biol Phys· February 2024

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The radioprotectant nano-genistein enhances radiotherapy efficacy of lung tumors in mice.
Michael D Kaytor, Artur A Serebrenik, Karen Lapanowski, Debra McFall, Matthew Jones

Transl Lung Cancer Res· May 2023

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A C57L/J Mouse Model of the Delayed Effects of Acute Radiation Exposure in the Context of Evolving Multi-Organ Dysfunction and Failure after Total-Body Irradiation with 2.5% Bone Marrow Sparing.
Allison Gibbs, Pawan Gupta, Buddha Mali, Yannick Poirier, Mathangi Gopalakrishnan, Michael D Kaytor

Radiat Res· April 2023

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The Radioprotectant, BIO 300, Protects the Lungs from Total-Body Irradiation Injury in C57L/J Mice.
Vijay K Singh, Artur A Serebrenik, Oluseyi O Fatanmi, Stephen Y Wise, Alana D Carpenter, Michael D Kaytor

Radiat Res· March 2023

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Safety, Pharmacokinetics, and Biomarkers of an Amorphous Solid Dispersion of Genistein, a Radioprotectant, in Healthy Volunteers.
Artur A Serebrenik, Carin W Verduyn, Michael D Kaytor

Clin Pharmacol Drug Dev· February 2023

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Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates.
Yaoxiang Li, Michael Girgis, Meth Jayatilake, Artur A Serebrenik, Amrita K Cheema, Michael D Kaytor

Sci Rep· August 2022

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Interspecies Comparison and Radiation Effect on Pharmacokinetics of BIO 300, a Nanosuspension of Genistein, after Different Routes of Administration in Mice and Non-Human Primates.
Ahmed M Salem, Isabel L Jackson, Allison Gibbs, Yannick Poirier, Diana Newman, Michael D Kaytor

Radiat Res· May 2022

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A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice.
Vijay K Singh, Oluseyi O Fatanmi, Stephen Y Wise, Alana Carpenter, Sara Nakamura-Peek, Michael D Kaytor

Int J Radiat Biol· April 2022

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Microbiome study in irradiated mice treated with BIO 300, a promising radiation countermeasure.
Amrita K Cheema, Yaoxiang Li, Jatinder Singh, Ryan Johnson, Michael Girgis, Michael D Kaytor

Anim Microbiome· October 2021

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Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure.
Michael Girgis, Yaoxiang Li, Junfeng Ma, Miloslav Sanda, Stephen Y Wise, Michael D Kaytor

Sci Rep· November 2020

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BIO 300, a Nanosuspension of Genistein, Mitigates Radiation-Induced Erectile Dysfunction and Sensitizes Human Prostate Cancer Xenografts to Radiation Therapy.
Isabel L Jackson, Rada Pavlovic, Allen A Alexander, Caroline Q Connors, Diana Newman, Michael D Kaytor

Int J Radiat Oncol Biol Phys· October 2019

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Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome.
Michael R Landauer, Adam J Harvey, Michael D Kaytor, Regina M Day

J Radiat Res· May 2019

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Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model.
Amrita K Cheema, Khyati Y Mehta, Paola T Santiago, Oluseyi O Fatanmi, Michael D Kaytor

Int J Mol Sci· March 2019

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BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model.
Isabel L Jackson, Andrew Zodda, Ganga Gurung, Radmila Pavlovic, Michael D Kaytor

Br J Pharmacol· December 2017

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Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury.
Jace W Jones, Isabel L Jackson, Zeljko Vujaskovic, Michael D Kaytor, Maureen A Kane

Pharm Res· December 2017

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Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease.
Subha Karumuthil-Melethil, Sahana Nagabhushan Kalburgi, Patrick Thompson, Michael Tropak, Michael D Kaytor

Hum Gene Ther· July 2016

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Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum.
Richard Grondin, Michael D Kaytor, Yi Ai, Peter T Nelson, Deepak R Thakker

Brain· April 2012

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DNA nanoparticles: detection of long-term transgene activity in brain using bioluminescence imaging.
David M Yurek, Anita M Fletcher, Matthew McShane, Tomasz H Kowalczyk, Linas Padegimas, Michael D Kaytor

Mol Imaging· October 2011

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A cell-based screen for modulators of ataxin-1 phosphorylation.
Michael D Kaytor, Courtney E Byam, Susan K Tousey, Samuel D Stevens, Huda Y Zoghbi

Hum Mol Genet· April 2005

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Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.
Tao Zu, Lisa A Duvick, Michael D Kaytor, Michael S Berlinger, Huda Y Zoghbi

J Neurosci· October 2004

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Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity.
Michael D Kaytor, Keith D Wilkinson, Stephen T Warren

J Neurochem· May 2004

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