Publications by authors named "Michael Edlund"

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BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells.
Anne Jämsä, Oscar Belda, Michael Edlund, Erik Lindström

J Biomed Sci· October 2011

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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.
Magnus Nilsson, Anna Karin Belfrage, Stefan Lindström, Horst Wähling, Charlotta Lindquist, Michael Edlund

Bioorg Med Chem Lett· July 2010

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The resorptive apparatus of osteoclasts supports lysosomotropism and increases potency of basic versus non-basic inhibitors of cathepsin K.
Karen Fuller, Erik Lindstrom, Michael Edlund, Ian Henderson, Urszula Grabowska

Bone· May 2010

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In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.
Oliver Lenz, Thierry Verbinnen, Tse-I Lin, Leen Vijgen, Maxwell D Cummings, Michael Edlund

Antimicrob Agents Chemother· May 2010

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Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
Fredrik Wångsell, Karin Gustafsson, Ingemar Kvarnström, Neera Borkakoti, Michael Edlund

Eur J Med Chem· March 2010

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Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target.
Maxwell D Cummings, Jimmy Lindberg, Tse-I Lin, Herman de Kock, Oliver Lenz, Michael Edlund

Angew Chem Int Ed Engl· February 2010

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In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.
Tse-I Lin, Oliver Lenz, Gregory Fanning, Thierry Verbinnen, Frédéric Delouvroy, Michael Edlund

Antimicrob Agents Chemother· April 2009

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Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
Sandrine Vendeville, Magnus Nilsson, Herman de Kock, Tse-I Lin, Dmitry Antonov, Michael Edlund

Bioorg Med Chem Lett· December 2008

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Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Pierre Raboisson, Herman de Kock, Asa Rosenquist, Magnus Nilsson, Lourdes Salvador-Oden, Michael Edlund

Bioorg Med Chem Lett· September 2008

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Properties of recombinant human plasma procarboxypeptidase U produced in mammalian and insect cells.
Mats Strömqvist, Lennart Hansson, Jan-Olof Andersson, Thord Johansson, Michael Edlund

Clin Chim Acta· September 2004

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Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
Lennart Hansson, Assar Bäckman, Annelii Ny, Michael Edlund, Elisabeth Ekholm

J Invest Dermatol· March 2002

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