Publications by authors named "Michael Heartlein"

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Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles.
James C Kaczmarek, Asha Kumari Patel, Luke H Rhym, Umberto Capasso Palmiero, Balkrishen Bhat, Michael W Heartlein

Biomaterials· August 2021

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mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo.
Yulia Rybakova, Piotr S Kowalski, Yuxuan Huang, John T Gonzalez, Michael W Heartlein

Mol Ther· August 2019

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Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy.
Frank DeRosa, Lianne Smith, Yinghua Shen, Yan Huang, Jing Pan, Michael W Heartlein

Mol Ther· April 2019

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Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium.
Asha Kumari Patel, James C Kaczmarek, Suman Bose, Kevin J Kauffman, Faryal Mir, Michael W Heartlein

Adv Mater· February 2019

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Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs.
Owen S Fenton, Kevin J Kauffman, Rebecca L McClellan, James C Kaczmarek, Manhao D Zeng, Michael W Heartlein

Angew Chem Int Ed Engl· October 2018

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Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells.
James C Kaczmarek, Kevin J Kauffman, Owen S Fenton, Kaitlyn Sadtler, Asha K Patel, Michael W Heartlein

Nano Lett· October 2018

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Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes.
Owen S Fenton, Kevin J Kauffman, James C Kaczmarek, Rebecca L McClellan, Siddharth Jhunjhunwala, Michael W Heartlein

Adv Mater· September 2017

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Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo.
Kevin J Kauffman, Faryal F Mir, Siddharth Jhunjhunwala, James C Kaczmarek, Juan E Hurtado, Michael W Heartlein

Biomaterials· December 2016

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Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs.
James C Kaczmarek, Asha K Patel, Kevin J Kauffman, Owen S Fenton, Matthew J Webber, Michael W Heartlein

Angew Chem Int Ed Engl· October 2016

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Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery.
Owen S Fenton, Kevin J Kauffman, Rebecca L McClellan, Eric A Appel, J Robert Dorkin, Michael W Heartlein

Adv Mater· April 2016

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Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.
Yizhou Dong, J Robert Dorkin, Weiheng Wang, Philip H Chang, Matthew J Webber, Michael Heartlein

Nano Lett· February 2016

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Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.
Kevin J Kauffman, J Robert Dorkin, Jung H Yang, Michael W Heartlein, Frank DeRosa

Nano Lett· November 2015

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CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder.
Pericles Calias, Mikhail Papisov, Jing Pan, Nancy Savioli, Vasily Belov, Michael W Heartlein

PLoS One· July 2012

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Safety evaluation of chronic intrathecal administration of heparan N-sulfatase in juvenile cynomolgus monkeys.
Richard W Pfeifer, Brian R Felice, Robert B Boyd, Mark T Butt, Juan A Ruiz, Michael W Heartlein

Drug Deliv Transl Res· June 2012

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Safety evaluation of chronic intrathecal administration of idursulfase-IT in cynomolgus monkeys.
Brian R Felice, Teresa L Wright, Robert B Boyd, Mark T Butt, Richard W Pfeifer, Michael W Heartlein

Toxicol Pathol· August 2011

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Iodine-124 as a label for pharmacological PET imaging.
Vasily V Belov, Ali A Bonab, Alan J Fischman, Michael Heartlein, Pericles Calias

Mol Pharm· June 2011

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Erythropoietin produced in a human cell line (Dynepo) has significant differences in glycosylation compared with erythropoietins produced in CHO cell lines.
Zahra Shahrokh, Louise Royle, Radka Saldova, Jonathan Bones, Jodie L Abrahams, Michael W Heartlein

Mol Pharm· February 2011

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In vitro characterization of an acetylcholine receptor-transferrin fusion protein for the treatment of myasthenia gravis.
Dennis Keefe, Chuenlei Parng, Dianna Lundberg, Satyajit Ray, Jennifer Martineau-Bosco, Michael Heartlein

Autoimmunity· December 2010

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Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts.
Sarah M Peterson, Andrea Iskenderian, Lynette Cook, Alla Romashko, Kristen Tobin, Michael W Heartlein

BMC Cancer· August 2010

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Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases.
Paolo G V Martini, Lynette C Cook, Scott Alderucci, Angela W Norton, Dianna M Lundberg, Michael W Heartlein

BMC Immunol· August 2010

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