Publications by authors named "Michael Jaye"

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The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.
Joseph P Marino, Lara S Kallander, Chun Ma, Hye-Ja Oh, Dennis Lee, Michael Jaye

Bioorg Med Chem Lett· October 2009

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Heme-oxygenase induction inhibits arteriolar thrombosis in vivo: effect of the non-substrate inducer cobalt protoporphyrin.
Douglas G Johns, Dorothy Zelent, Zhaohui Ao, Benjamin T Bradley, Alexandra Cooke, Michael C Jaye

Eur J Pharmacol· March 2009

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Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
David G Washburn, Tram H Hoang, Nino Campobasso, Angela Smallwood, Derek J Parks, Michael Jaye

Bioorg Med Chem Lett· February 2009

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Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.
Krista B Goodman, Michael J Bury, Mui Cheung, Maria A Cichy-Knight, Sarah E Dowdell, Michael C Jaye

Bioorg Med Chem Lett· January 2009

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Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment.
Caroline A Phelan, Joseph M Weaver, David J Steger, Shree Joshi, Jeffrey T Maslany, Michael Jaye

Mol Endocrinol· October 2008

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A high-throughput screen for endothelial lipase using HDL as substrate.
Paul M Keller, Timothy Rust, Dennis J Murphy, Rosalie Matico, John J Trill, Michael Jaye

J Biomol Screen· July 2008

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Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.
Lea Sarov-Blat, Robert S Kiss, Bassam Haidar, Nihan Kavaslar, Michael Jaye

Arterioscler Thromb Vasc Biol· May 2007

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Perilipin, a potential substitute for adipophilin in triglyceride storage in human macrophages.
Guilhem Larigauderie, Mohamed Amine Bouhlel, Christophe Furman, Michael Jaye, Jean-Charles Fruchart

Atherosclerosis· November 2006

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Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation.
Guilhem Larigauderie, Clarisse Cuaz-Pérolin, Amena B Younes, Christophe Furman, Catherine Lasselin, Michael Jaye

FEBS J· August 2006

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Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study.
Karpagam Aravindhan, Christine L Webb, Michael Jaye, Avijit Ghosh, Robert N Willette

J Lipid Res· June 2006

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Poloxamer 407 (P-407)-mediated reduction in the gene expression of ATP-binding-cassette transporter A1 may contribute to increased cholesterol in peripheral tissues of P-407-treated rats.
Thomas P Johnston, Michael Jaye, Christine L Webb, John A Krawiec, Sara Pilar Alom-Ruiz

Eur J Pharmacol· May 2006

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Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo.
Snehal U Naik, Xun Wang, Jaqueline S Da Silva, Michael Jaye, Colin H Macphee

Circulation· January 2006

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Synthetic LXR agonists increase LDL in CETP species.
Pieter H E Groot, Nigel J Pearce, John W Yates, Claire Stocker, Charles Sauermelch, Michael Jaye

J Lipid Res· October 2005

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Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Michael C Jaye, John A Krawiec, Nino Campobasso, Angela Smallwood, Chunyan Qiu

J Med Chem· August 2005

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Endothelial lipase and HDL metabolism.
Michael Jaye, John Krawiec

Curr Opin Lipidol· April 2004

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Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis.
Guilhem Larigauderie, Christophe Furman, Michael Jaye, Catherine Lasselin, Corinne Copin

Arterioscler Thromb Vasc Biol· March 2004

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Identification of novel isoform-selective inhibitors within class I histone deacetylases.
Erding Hu, Edward Dul, Chiu-Mei Sung, Zunxuan Chen, Robert Kirkpatrick, Michael Jaye

J Pharmacol Exp Ther· November 2003

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LXR agonists for the treatment of atherosclerosis.
Michael Jaye

Curr Opin Investig Drugs· September 2003

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