Publications by authors named "Michael W Laird"

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Bax and Bak knockout apoptosis-resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed-batch culture process.
Danming Tang, Cynthia Lam, Niels Bauer, Simon Auslaender, Brad Snedecor, Michael W Laird, Shahram Misaghi

March 2022

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Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies.
Gavin C Barnard, Michelle Zhou, Amy Shen, Inn H Yuk, Michael W Laird

Biotechnol Prog· February 2024

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Enzymatic basis of the Fc-selective intra-chain disulfide reduction and free thiol content variability in an antibody produced in Escherichia coli.
Tomasz K Baginski, Karthik Veeravalli, Rebekah McKenna, Christopher Williams, Katherine Wong, Michael W Laird

Microb Cell Fact· August 2022

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Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase-mediated cassette exchange system.
Domingos Ng, Meixia Zhou, Dejin Zhan, Shirley Yip, Peggy Ko, Michael W Laird

Biotechnol Prog· July 2021

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Advancing Biologics Development Programs with Legacy Cell Lines: Advantages and Limitations of Genetic Testing for Addressing Clonality Concerns Prior to Availability of Late Stage Process and Product Consistency Data.
Paul Wu, Taymar Hartman, Louise Almond, Jennitte Stevens, John Thrift, Michael W Laird

PDA J Pharm Sci Technol· January 2021

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Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position.
Joe Carver, Domingos Ng, Michelle Zhou, Peggy Ko, Dejin Zhan, Michael W Laird

Biotechnol Prog· July 2020

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Implementation of Plate Imaging for Demonstration of Monoclonality in Biologics Manufacturing Development.
Kyle Zingaro, David Shaw, Jerry Carson, Anke Mayer-Bartschmid, Christian Bender, Michael W Laird

PDA J Pharm Sci Technol· May 2019

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Pyruvate Kinase Muscle-1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.
Danming Tang, Jayashree Subramanian, Benjamin Haley, Jordan Baker, Lucas Luo, Michael W Laird

Biotechnol J· April 2019

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Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally-derived or not.
Yizhou Zhou, David Shaw, Cynthia Lam, Joni Tsukuda, Mandy Yim, Michael W Laird

Biotechnol Prog· May 2018

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Development and characterization of an automated imaging workflow to generate clonally-derived cell lines for therapeutic proteins.
David Shaw, Mandy Yim, Joni Tsukuda, John C Joly, Andy Lin, Michael W Laird

Biotechnol Prog· May 2018

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Strain engineering to reduce acetate accumulation during microaerobic growth conditions in Escherichia coli.
Karthik Veeravalli, Tony Schindler, Emily Dong, Masaki Yamada, Ryan Hamilton, Michael W Laird

Biotechnol Prog· March 2018

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A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies.
Zhilan Hu, Wendy Hsu, Abby Pynn, Domingos Ng, Donna Quicho, Michael W Laird

Biotechnol Prog· November 2017

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Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells.
Zhilan Hu, Danming Tang, Shahram Misaghi, Guoying Jiang, Christopher Yu, Michael W Laird

Biotechnol Prog· May 2017

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Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli.
Karthik Veeravalli, Michael W Laird

Bioengineered· February 2016

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Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli.
Karthik Veeravalli, Michael W Laird, Mark Fedesco, Yu Zhang, X Christopher Yu

Biotechnol Prog· December 2015

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Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid.
Melissa Mun, Stefanie Khoo, Aline Do Minh, James Dvornicky, Melody Trexler-Schmidt, Michael W Laird

Biotechnol Bioeng· April 2015

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Effect of individual Fc methionine oxidation on FcRn binding: Met252 oxidation impairs FcRn binding more profoundly than Met428 oxidation.
Xuan Gao, Junyan A Ji, Karthik Veeravalli, Y John Wang, Taylor Zhang, Michael W Laird

J Pharm Sci· February 2015

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Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies.
Lauren Feeney, Veronica Carvalhal, X Christopher Yu, Betty Chan, David A Michels, Michael W Laird

Biotechnol Bioeng· April 2013

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Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture.
Kristen L Koterba, Trissa Borgschulte, Michael W Laird

J Biotechnol· January 2012

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Characterization of a nutrient feed precipitate from an E. coli fermentation process.
Lauren Speciner, Erin Mallon, Susan Leung, Michael W Laird, Osigwe Esue

Biotechnol Prog· January 2011

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Use of disposable reactors to generate inoculum cultures for E. coli production fermentations.
Ekta Mahajan, Timothy Matthews, Ryan Hamilton, Michael W Laird

Biotechnol Prog· December 2010

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Mechanism of antibody reduction in cell culture production processes.
Yung-Hsiang Kao, Daniel P Hewitt, Melody Trexler-Schmidt, Michael W Laird

Biotechnol Bioeng· November 2010

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Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells.
Donglin Guo, Albert Gao, David A Michels, Lauren Feeney, Marian Eng, Michael W Laird

Biotechnol Bioeng· September 2010

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High-yield expression of human vascular endothelial growth factor VEGF(165) in Escherichia coli and purification for therapeutic applications.
Shelly A Pizarro, Jane Gunson, Matthew J Field, Rachel Dinges, Stefanie Khoo, Michael W Laird

Protein Expr Purif· August 2010

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Characterization of a monoclonal antibody cell culture production process using a quality by design approach.
Brian Horvath, Melissa Mun, Michael W Laird

Mol Biotechnol· July 2010

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