Publications by authors named "Michaela Matthey"

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Pharmacological Gq targeting prevents asthmatic airway remodeling.
Jennifer M Dietrich, Michaela Matthey, Annika Simon, Alexander Seidinger, Cynthia Koziol-White

Mol Ther· October 2025

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A 'second hit' mouse model for group 2 and 3 pulmonary hypertension: combination of aortic banding and hypoxia exposure.
Laura K Pallos, Michaela Matthey, Michael Hesse, Bernd K Fleischmann, Wilhelm Röll

Cardiovasc Res· October 2025

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Deep learning based automation of mean linear intercept quantification in COPD research.
Lars Leyendecker, Anna Louisa Weltin, Florian Nienhaus, Michaela Matthey, Bastian Nießing

Front Big Data· June 2025

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Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models.
Ghazl Al Hamwi, Mohamad Wessam Alnouri, Sven Verdonck, Piotr Leonczak, Shaswati Chaki, Michaela Matthey

Signal Transduct Target Ther· April 2025

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Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE mice.
Alexander Brückner, Adrian Brandtner, Sarah Rieck, Michaela Matthey, Caroline Geisen

Angiogenesis· November 2024

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Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension.
Alexander Seidinger, Richard Roberts, Yan Bai, Marion Müller, Eva Pfeil, Michaela Matthey

EMBO Mol Med· August 2024

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The endocannabinoid anandamide is an airway relaxant in health and disease.
Annika Simon, Thomas von Einem, Alexander Seidinger, Michaela Matthey, Laura Bindila

Nat Commun· November 2022

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A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Alessandra Ghigo, Alessandra Murabito, Valentina Sala, Anna Rita Pisano, Serena Bertolini, Michaela Matthey

Sci Transl Med· March 2022

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Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis.
Sarah Rieck, Sofia Kilgus, Johanna H Meyer, Hao Huang, Lan Zhao, Michaela Matthey

Arterioscler Thromb Vasc Biol· December 2021

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Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890-Fit for Translation?
Jonathan G Schlegel, Mariam Tahoun, Alexander Seidinger, Jan H Voss, Markus Kuschak, Michaela Matthey

ACS Pharmacol Transl Sci· April 2021

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Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.
Eva Marie Pfeil, Julian Brands, Nicole Merten, Timo Vögtle, Maddalena Vescovo, Michaela Matthey

Mol Cell· December 2020

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Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gα Protein Inhibitors in Biological Samples.
Markus Kuschak, Jonathan G Schlegel, Marion Schneider, Stefan Kehraus, Jan H Voss, Michaela Matthey

Front Chem· September 2020

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Cell-permeable high-affinity tracers for G proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H Voss, Jaspal Garg, Michaela Matthey

Br J Pharmacol· April 2020

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The β agonist terbutaline specifically decreases pulmonary arterial pressure under normoxia and hypoxia via α adrenoceptor antagonism.
Vanessa Neumann, Ralf Knies, Alexander Seidinger, Annika Simon, Kristina Lorenz, Michaela Matthey

FASEB J· May 2018

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Targeted inhibition of G signaling induces airway relaxation in mouse models of asthma.
Michaela Matthey, Richard Roberts, Alexander Seidinger, Annika Simon, Ralf Schröder

Sci Transl Med· September 2017

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The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy.
Georg D Duerr, Jan C Heinemann, Georg Suchan, Elvis Kolobara, Daniela Wenzel, Michaela Matthey

Basic Res Cardiol· July 2014

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RGD peptides induce relaxation of pulmonary arteries and airways via β3-integrins.
Julia Welschoff, Michaela Matthey, Daniela Wenzel

FASEB J· May 2014

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Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction.
Daniela Wenzel, Michaela Matthey, Laura Bindila, Raissa Lerner, Beat Lutz

Proc Natl Acad Sci U S A· November 2013

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Identification of a novel vasoconstrictor peptide specific for the systemic circulation.
Daniela Wenzel, Manuel Koch, Michaela Matthey, Jan C Heinemann, Bernd K Fleischmann

Hypertension· June 2012

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O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice.
Gautam V Shrikhande, Salvatore T Scali, Cleide G da Silva, Scott M Damrauer, Eva Csizmadia, Michaela Matthey

PLoS One· December 2010

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beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway.
Daniela Wenzel, Ralf Knies, Michaela Matthey, Alexandra M Klein, Julia Welschoff

Hypertension· July 2009

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