Publications by authors named "Mike Tobyn"

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Characterizing C Spectral Assignments and Substituent Distributions of Hydroxypropylmethylcellulose Acetyl Succinate Using Dynamic Nuclear Polarization Nuclear Magnetic Resonance Spectroscopy.
Ronan P Cosquer, Arthur C Pinon, Mária Šoltésová, Lucy E Hawarden, Anuji Abraham, Mike Tobyn

Mol Pharm· October 2025

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Understanding the impact of excipient variability on oral solid dosage form performance: A possible role for multivariate data analysis, in the form of principal component analysis.
Pauline H M Janssen, Bastiaan H J Dickhoff, Ana Ferreira, John Gamble, Rachael Shinebaum, Mike Tobyn

J Pharm Sci· October 2025

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Titanium Dioxide (E171 Grade) and the Search For Replacement Opacifiers and Colorants: Supplier Readiness Survey, Case Studies and Regulatory Perspective.
Bruno Hancock, David Harris, Jonathan Kaye, Liz Meehan, Jason Melnick, Mike Tobyn

J Pharm Sci· May 2024

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Determining the Impact of Roller Compaction Processing Conditions on Granulate and API Properties: Impact of Formulation API Load.
James Clarke, John F Gamble, John W Jones, Mike Tobyn, Andrew Ingram

AAPS PharmSciTech· January 2024

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Non-contact Laser Interferometer Method to Characterize Tablet Punches: New Methodology to Assess Surface Roughness.
Helen Hughes, Michael Leane, Patrick S Wray, Mike Tobyn

AAPS PharmSciTech· October 2023

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Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression Hypromellose from Different Vendors.
Nihad Mawla, Maen Alshafiee, John Gamble, Mike Tobyn, Lande Liu

Pharmaceutics· August 2023

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Morphological distribution mapping: Utilisation of modelling to integrate particle size and shape distributions.
John F Gamble, Ilgaz Akseli, Ana P Ferreira, Michael Leane, Stephen Thomas, Mike Tobyn

Int J Pharm· March 2023

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In-Process Vapor Composition Monitoring in Application to Lyophilization of Ammonium Salt Formulations.
Andrew D Strongrich, Mike Tobyn, Lavanya K Iyer, Yirang Park, JiaMei Hong

J Pharm Sci· January 2023

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The Role of Titanium Dioxide (E171) and the Requirements for Replacement Materials in Oral Solid Dosage Forms: An IQ Consortium Working Group Review.
Ross Blundell, Paul Butterworth, Anne Charlier, Dominick Daurio, Matthias Degenhardt, Mike Tobyn

J Pharm Sci· November 2022

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Particle Property Characterization and Data Curation for Effective Powder Property Modeling in the Pharmaceutical Industry.
Robert C Wadams, Ilgaz Akseli, Jacob Albrecht, Ana P Ferreira, John F Gamble, Mike Tobyn

AAPS PharmSciTech· October 2022

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Characterization of the Morphological Nature of Hollow Spray Dried Dispersion Particles Using X-ray Submicron-Computed Tomography.
John F Gamble, Mike Tobyn, Shawn Zhang, Aiden Zhu, Jakub Šalplachta

AAPS PharmSciTech· December 2021

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Determining the Impact of Roller Compaction Processing Conditions on Granule and API Properties.
James Clarke, John F Gamble, John W Jones, Mike Tobyn, Neil Dawson

AAPS PharmSciTech· August 2020

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Multivariate analysis as a method to understand variability in a complex excipient, and its contribution to formulation performance.
Mike Tobyn, Ana Patricia Ferreira, Jane Lightfoot, Elaine B Martin, Manish Ghimire

Pharm Dev Technol· December 2018

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Enhanced Understanding of Pharmaceutical Materials Through Advanced Characterisation and Analysis.
Ana Patricia Ferreira, John F Gamble, Michael M Leane, Hyunsoo Park, Dolapo Olusanmi, Mike Tobyn

AAPS PharmSciTech· November 2018

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Sticking and Picking in Pharmaceutical Tablet Compression: An IQ Consortium Review.
Sayantan Chattoraj, Patrick Daugherity, Todd McDermott, Angela Olsofsky, Wyatt J Roth, Mike Tobyn

J Pharm Sci· September 2018

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Solubility enhancement and solid-state characterisation.
Mike Tobyn

Pharm Dev Technol· September 2018

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Determination of process variables affecting drug particle attrition withinmulti-component blends during powder feed transmission.
John F Gamble, Andrew B Dennis, Paul Hutchins, John W Jones, Pauline Musembi, Mike Tobyn

Pharm Dev Technol· November 2017

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Use of similarity scoring in the development of oral solid dosage forms.
Ana P Ferreira, Dolapo Olusanmi, Omar Sprockel, Admassu Abebe, Faranak Nikfar, Mike Tobyn

Int J Pharm· December 2016

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John Staniforth-An appreciation: The non-conformist nonconformist.
Mike Tobyn, Rob Price

Int J Pharm· December 2016

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Application of X-ray microtomography for the characterisation of hollow polymer-stabilised spray dried amorphous dispersion particles.
John F Gamble, Masako Terada, Christian Holzner, Leah Lavery, Sarah J Nicholson, Mike Tobyn

Int J Pharm· August 2016

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Multivariate analysis in the pharmaceutical industry: enabling process understanding and improvement in the PAT and QbD era.
Ana P Ferreira, Mike Tobyn

Pharm Dev Technol· April 2016

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Investigation into process-induced de-aggregation of cohesive micronised API particles.
Magnus Hoffmann, Patrick S Wray, John F Gamble, Mike Tobyn

Int J Pharm· September 2015

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Application of image-based particle size and shape characterization systems in the development of small molecule pharmaceuticals.
John F Gamble, Mike Tobyn, Rhye Hamey

J Pharm Sci· May 2015

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Monitoring process induced attrition of drug substance particles within formulated blends.
John F Gamble, Magnus Hoffmann, Helen Hughes, Paul Hutchins, Mike Tobyn

Int J Pharm· August 2014

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Application of imaging based tools for the characterisation of hollow spray dried amorphous dispersion particles.
John F Gamble, Ana P Ferreira, Mike Tobyn, Lynn DiMemmo, Kyle Martin

Int J Pharm· April 2014

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