Publications by authors named "Mimi Quan"

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Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.
Zilun Hu, Doree Sitkoff, Peter W Glunz, Yan Zou, Cailan Wang, Mimi L Quan

Bioorg Med Chem Lett· May 2023

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Improved efficacy/safety profile of factor XIa inhibitor BMS-724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys.
Pancras C Wong, Mimi L Quan

Res Pract Thromb Haemost· May 2021

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Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
Zilun Hu, Cailan Wang, Peter W Glunz, Julia Li, Nathan L Cheadle, Mimi L Quan

Bioorg Med Chem Lett· November 2020

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Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors.
Zilun Hu, Cailan Wang, Doree Sitkoff, Nathan L Cheadle, Songmei Xu, Mimi L Quan

Bioorg Med Chem Lett· November 2020

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Factor XIa Inhibitors as New Anticoagulants.
Mimi L Quan, Donald J P Pinto, Joanne M Smallheer, William R Ewing, Karen A Rossi

J Med Chem· September 2018

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Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Zilun Hu, Cailan Wang, Wei Han, Karen A Rossi, Jeffrey M Bozarth, Mimi L Quan

Bioorg Med Chem Lett· April 2018

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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).
Donald J P Pinto, Michael J Orwat, Leon M Smith, Mimi L Quan, Patrick Y S Lam

J Med Chem· December 2017

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Macrocyclic factor XIa inhibitors.
Cailan Wang, James R Corte, Karen A Rossi, Jeffrey M Bozarth, Yiming Wu, Mimi L Quan

Bioorg Med Chem Lett· September 2017

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Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
James R Corte, Wu Yang, Tianan Fang, Yufeng Wang, Honey Osuna, Mimi L Quan

Bioorg Med Chem Lett· August 2017

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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.
James R Corte, Tianan Fang, Honey Osuna, Donald J P Pinto, Karen A Rossi, Mimi L Quan

J Med Chem· February 2017

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Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
James R Corte, Tianan Fang, Donald J P Pinto, Michael J Orwat, Alan R Rendina, Mimi L Quan

Bioorg Med Chem· May 2016

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Novel phenylalanine derived diamides as Factor XIa inhibitors.
Leon M Smith, Michael J Orwat, Zilun Hu, Wei Han, Cailan Wang, Mimi L Quan

Bioorg Med Chem Lett· January 2016

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In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.
Pancras C Wong, Mimi L Quan, Carol A Watson, Earl J Crain, Mark R Harpel

J Thromb Thrombolysis· November 2015

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Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety.
Zilun Hu, Pancras C Wong, Paul J Gilligan, Wei Han, Kumar B Pabbisetty, Mimi L Quan

ACS Med Chem Lett· May 2015

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Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Donald J P Pinto, Joanne M Smallheer, James R Corte, Erin J D Austin, Cailan Wang, Mimi L Quan

Bioorg Med Chem Lett· April 2015

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Pyridine and pyridinone-based factor XIa inhibitors.
James R Corte, Tianan Fang, Jon J Hangeland, Todd J Friends, Alan R Rendina, Mimi L Quan

Bioorg Med Chem Lett· February 2015

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Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.
Jon J Hangeland, Todd J Friends, Karen A Rossi, Joanne M Smallheer, Cailan Wang, Mimi L Quan

J Med Chem· December 2014

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Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors.
Mimi L Quan, Pancras C Wong, Cailan Wang, Francis Woerner, Joanne M Smallheer

J Med Chem· February 2014

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Inhibition of factor XIa as a new approach to anticoagulation.
William A Schumacher, Joseph M Luettgen, Mimi L Quan, Dietmar A Seiffert

Arterioscler Thromb Vasc Biol· March 2010

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Phenyltriazolinones as potent factor Xa inhibitors.
Mimi L Quan, Donald J P Pinto, Karen A Rossi, Steven Sheriff, Richard S Alexander

Bioorg Med Chem Lett· February 2010

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Sulfonamidolactam inhibitors of coagulation factor Xa.
Joanne M Smallheer, Shuaige Wang, Mia L Laws, Suanne Nakajima, Zilun Hu, Mimi L Quan

Bioorg Med Chem Lett· April 2008

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Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.
Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi Quan

Drug Metab Dispos· February 2008

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Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors.
Jeffrey G Varnes, Dean A Wacker, Irina C Jacobson, Mimi L Quan, Christopher D Ellis

Bioorg Med Chem Lett· December 2007

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Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
Pancras C Wong, Earl J Crain, Carol A Watson, Ruth R Wexler, Patrick Y S Lam, Mimi L Quan

J Thromb Thrombolysis· August 2007

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Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties.
Donald J P Pinto, Robert A Galemmo, Mimi L Quan, Michael J Orwat, Charles Clark

Bioorg Med Chem Lett· November 2006

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