Publications by authors named "Mitchell Taub"

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Protein Abundance of Clinically Relevant Drug-Metabolizing Hydrolases in Human Liver and Intestine by Targeted versus Global Proteomics Approaches: A Comparative Study.
Dilip Kumar Singh, Deepak Ahire, Robert S Jones, Ryota Kikuchi, Bin Ma, Mitchell Taub

J Proteome Res· November 2025

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Correction: One-step Immobilization of Human α-1-acid Glycoprotein on Magnetic Beads: A Rapid Method for Small Molecule hAGP Binding Study.
Ting Wang, Hamid Samareh Afsari, Steven Anderlot, Aaron M Teitelbaum, Mitchell E Taub

AAPS J· October 2025

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One-step Immobilization of Human α-1-acid Glycoprotein on Magnetic Beads: A Rapid Method for Small Molecule hAGP Binding Study.
Ting Wang, Hamid Samareh Afsari, Steven Anderlot, Aaron M Teitelbaum, Mitchell E Taub

AAPS J· September 2025

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Novel role of serum albumin imidase activity in the formation of BI 761036 (M232), a major metabolite of iclepertin.
Klairynne G Raymond, Mitchell E Taub, Stefan Wölke, Sebastian Otto, Tom S Chan

Drug Metab Dispos· July 2025

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Identification of selective inhibitors of uridine 5'-diphospho-glucuronosyltransferase (UGT) 1A3 and UGT1A8 and their application in UGT reaction phenotyping studies in human liver and intestinal microsomes.
Ting Wang, Alyssa P Anderson, Andrew S Yu, Mitchell E Taub, Tom S Chan

Drug Metab Dispos· May 2025

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Improved clearance predictions for aldehyde oxidase substrates using a novel triculture human hepatocyte model.
Alexander Byer-Alcorace, Cody Thomas, Mitchell E Taub, Stephanie Piekos

Drug Metab Dispos· April 2025

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A Radioactivity-mass Spectrometry Calibration Method Coupled with Biosynthesis to Generate a Metabolite Standard for Enzyme Kinetics Studies.
Ting Wang, Cody Thomas, Bachir Latli, Matt Hrapchak, Mitchell E Taub

J Pharm Sci· September 2024

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Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes.
Ting Wang, Andrea Whitcher-Johnstone, Young Sun Scaringella, Monica Keith-Luzzi, Juntang Shao, Mitchell E Taub

J Pharm Sci· July 2024

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Survey of Pharmaceutical Industry's Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group.
Helen E Rollison, Pallabi Mitra, Hugues Chanteux, Zhizhou Fang, Xiaomin Liang, Mitchell Taub

Drug Metab Dispos· June 2024

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A novel system to determine activity of individual uridine 5'-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads.
Ting Wang, Mitchell E Taub, Tom S Chan

J Biol Chem· May 2024

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Mechanistic Static Model based Prediction of Transporter Substrate Drug-Drug Interactions Utilizing Atorvastatin and Rifampicin.
Pallabi Mitra, Rumanah Kasliwala, Laeticia Iboki, Shilpa Madari, Zachary Williams, Mitchell E Taub

Pharm Res· December 2023

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Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin.
Tom S Chan, Alexander J Byer-Alcorace, Bachir Latli, Pingrong Liu, Hlaing H Maw, Mitchell E Taub

Pharm Res· August 2023

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The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system.
Jessica R Weaver, Justin J Odanga, Kristina K Wolf, Stephanie Piekos, Mercedes Biven, Mitchell Taub

Toxicol In Vitro· February 2023

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Mode of action and human relevance assessment of male CD-1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozin.
Jonathan A Phillips, Mitchell E Taub, Matthew S Bogdanffy, Jing Yuan, Brian Knight

J Appl Toxicol· October 2022

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Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Sabrina T Wiebe, Thomas Giessmann, Kathrin Hohl, Sven Schmidt-Gerets, Edith Hauel, Mitchell E Taub

Clin Pharmacokinet· December 2020

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Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions.
Hannah Britz, Nina Hanke, Mitchell E Taub, Ting Wang, Bhagwat Prasad

Pharm Res· November 2020

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Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).
Laura E Russell, Mary Alexandra Schleiff, Eric Gonzalez, Aaron G Bart, Fabio Broccatelli, Mitchell E Taub

Drug Metab Rev· August 2020

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Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism.
Alexander M Horspool, Ting Wang, Young-Sun Scaringella, Mitchell E Taub, Tom S Chan

Drug Metab Dispos· August 2020

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Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture.
Tom S Chan, Young-Sun Scaringella, Klairynne Raymond, Mitchell E Taub

Drug Metab Dispos· August 2020

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Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
Maciej J Zamek-Gliszczynski, Mitchell E Taub, Paresh P Chothe, Xiaoyan Chu, Kathleen M Giacomini

Clin Pharmacol Ther· November 2018

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Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions.
Peter Stopfer, Thomas Giessmann, Kathrin Hohl, Sabine Hutzel, Sven Schmidt, Mitchell E Taub

Br J Clin Pharmacol· September 2018

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A Predominant Oxidative Renal Metabolite of Empagliflozin in Male Mice Is Cytotoxic in Mouse Renal Tubular Cells but not Genotoxic.
James D Smith, Zimei Huang, Patricia A Escobar, Pamela Foppiano, Hlaing Maw, Mitchell Taub

Int J Toxicol· July 2018

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Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling.
Pallabi Mitra, Samantha Weinheimer, Meeghan Michalewicz, Mitchell E Taub

Drug Metab Dispos· July 2018

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-Methylation of BI 187004 by Thiol -Methyltransferase.
Hlaing H Maw, Xingzhong Zeng, Scot Campbell, Mitchell E Taub, Aaron M Teitelbaum

Drug Metab Dispos· June 2018

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Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail.
Peter Stopfer, Thomas Giessmann, Kathrin Hohl, Ashish Sharma, Naoki Ishiguro, Mitchell E Taub

Eur J Drug Metab Pharmacokinet· February 2018

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