Publications by authors named "Nancy Agrawal"

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In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters.
Xiao-Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Nancy Agrawal

J Clin Pharmacol· September 2025

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Bemnifosbuvir and ruzasvir in combination exhibit potent synergistic antiviral activity in vitro while maintaining a favorable nonclinical safety profile in vivo.
Steven S Good, Shouqi Luo, Kai Lin, Alex Vo, Nancy G B Agrawal

Antiviral Res· May 2025

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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
James J Monroe, Keith Q Tanis, Alexei A Podtelezhnikov, Truyen Nguyen, Sam V Machotka, Nancy G B Agrawal

Toxicol Sci· September 2020

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Comparison of Deconvolution-Based and Absorption Modeling IVIVC for Extended Release Formulations of a BCS III Drug Development Candidate.
Filippos Kesisoglou, Binfeng Xia, Nancy G B Agrawal

AAPS J· November 2015

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Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888, a VEGFR-2/FLT-3 kinase inhibitor.
Marian Iwamoto, Evan J Friedman, Laura Sepp-Lorenzino, Jennifer E Talaty, Nancy G B Agrawal

Cancer Chemother Pharmacol· February 2015

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Lack of meaningful effect of ridaforolimus on the pharmacokinetics of midazolam in cancer patients: model prediction and clinical confirmation.
Mark Stroh, Jennifer Talaty, Punam Sandhu, Jacqueline McCrea, Amita Patnaik, Nancy Agrawal

J Clin Pharmacol· November 2014

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Clinical pharmacology profile of vorinostat, a histone deacetylase inhibitor.
Marian Iwamoto, Evan J Friedman, Punam Sandhu, Nancy G B Agrawal, Eric H Rubin

Cancer Chemother Pharmacol· September 2013

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Merck's perspective on the implementation of dried blood spot technology in clinical drug development - why, when and how.
Yang Xu, Eric J Woolf, Nancy Gb Agrawal, Prajakti Kothare, Vincenzo Pucci

Bioanalysis· February 2013

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Pharmacokinetic evaluation of rofecoxib : comparison of tablet and suspension formulations.
Jules I Schwartz, Patrick J Larson, Arturo G Porras, Kala-Jyoti Viswanathan-Aiyer, Nancy G B Agrawal

Clin Drug Investig· October 2012

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A single supratherapeutic dose of ridaforolimus does not prolong the QTc interval in patients with advanced cancer.
Richard M Lush, Amita Patnaik, Daniel Sullivan, Kyriakos P Papadopoulos, Michele Trucksis, Nancy Agrawal

Cancer Chemother Pharmacol· October 2012

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The minimal impact of food on the pharmacokinetics of ridaforolimus.
Mark Stroh, Xiaodong Li, Sabrina Marsilio, Deborah Panebianco, Amy Johnson-Levonas, Nancy Agrawal

Cancer Chemother Pharmacol· July 2012

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A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors.
Kyle Holen, Robert DiPaola, Glenn Liu, Antoinette R Tan, George Wilding, Nancy Agrawal

Invest New Drugs· June 2012

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The effect of multiple doses of rifampin and ketoconazole on the single-dose pharmacokinetics of ridaforolimus.
Mark Stroh, John Palcza, Jacqueline McCrea, Sabrina Marsilio, Sheila Breidinger, Nancy Agrawal

Cancer Chemother Pharmacol· May 2012

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In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
John R Atack, Karen A Maubach, Keith A Wafford, Desmond O'Connor, A David Rodrigues, Nancy G B Agrawal

J Pharmacol Exp Ther· November 2009

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A 1-step Bayesian predictive approach for evaluating in vitro in vivo correlation (IVIVC).
A Lawrence Gould, Nancy G B Agrawal, Thanh V Goel, Shaun Fitzpatrick

Biopharm Drug Dispos· October 2009

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Examination of the effect of increasing doses of etoricoxib on oral methotrexate pharmacokinetics in patients with rheumatoid arthritis.
Jules I Schwartz, Nancy G B Agrawal, P H Wong, Jutta Miller, Kenneth Bachmann

J Clin Pharmacol· October 2009

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The effect of etoricoxib on the pharmacokinetics of oral contraceptives in healthy participants.
Jules Schwartz, Thomas Hunt, William B Smith, Peggy Wong, Patrick Larson, Nancy Agrawal

J Clin Pharmacol· July 2009

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Tolerability, pharmacokinetics and night-time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects.
Julia Boyle, Philippe Danjou, Robert Alexander, Nicole Calder, Cynthia Gargano, Nancy Agrawal

Br J Clin Pharmacol· February 2009

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Evaluation of the pharmacokinetics of digoxin in healthy subjects receiving etoricoxib.
Jules I Schwartz, Nancy G B Agrawal, Martin Wehling, Bret J Musser, Carol P Gumbs

Br J Clin Pharmacol· December 2008

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Multiple-dose pharmacokinetics, pharmacodynamics, and safety of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, in healthy male volunteers.
Carol Addy, Paul Rothenberg, Susie Li, Anup Majumdar, Nancy Agrawal

J Clin Pharmacol· June 2008

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Safety, tolerability, pharmacokinetics, and pharmacodynamic properties of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, for the treatment of obesity: results from a double-blind, placebo-controlled, single oral dose study in healthy volunteers.
Carol Addy, Susie Li, Nancy Agrawal, Julie Stone, Anup Majumdar

J Clin Pharmacol· April 2008

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Lack of effect of antacids on single-dose pharmacokinetics of etoricoxib.
Jules I Schwartz, Nancy G B Agrawal, Uma A Kher, Marina DeSmet, Paul F Cavanaugh

J Clin Pharmacol· October 2007

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The effect of etoricoxib on the pharmacodynamics and pharmacokinetics of warfarin.
Jules I Schwartz, Nancy G B Agrawal, Alan H Hartford, Josee Cote, Thomas L Hunt

J Clin Pharmacol· May 2007

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A study to determine the effects of food and multiple dosing on the pharmacokinetics of vorinostat given orally to patients with advanced cancer.
Eric H Rubin, Nancy G B Agrawal, Evan J Friedman, Pamela Scott, Kathryn E Mazina

Clin Cancer Res· December 2006

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Metabolism and disposition of a potent and selective GABA-Aalpha2/3 receptor agonist in healthy male volunteers.
Stacey L Polsky-Fisher, Stanley Vickers, Donghui Cui, Raju Subramanian, Byron H Arison, Nancy G B Agrawal

Drug Metab Dispos· June 2006

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