Publications by authors named "Nancy C Hancock"

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Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions.
Kenta Ishii, Stefan J Hermans, Maria Eleni Georgopoulou, Tracy L Nero, Nancy C Hancock

FEBS J· December 2024

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Structural biology of cell surface receptors implicated in Alzheimer's disease.
Stefan J Hermans, Tracy L Nero, Craig J Morton, Jonathan H Gooi, Gabriela A N Crespi, Nancy C Hancock

Biophys Rev· February 2022

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Development of [F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.
Siu Wai Wong, Lucy Vivash, Ramesh Mudududdla, Nghi Nguyen, Stefan J Hermans, Nancy C Hancock

Eur J Med Chem· December 2021

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Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.
Luke A Miles, Stefan J Hermans, Gabriela A N Crespi, Jonathan H Gooi, Larissa Doughty, Nancy C Hancock

iScience· September 2019

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A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.
Anastasia De Luca, Lorien J Parker, Wee Han Ang, Carlo Rodolfo, Valentina Gabbarini, Nancy C Hancock

Proc Natl Acad Sci U S A· July 2019

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Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Stefan J Hermans, David B Ascher, Nancy C Hancock, Jessica K Holien, Belinda J Michell

Protein Sci· February 2015

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Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.
Jacob L Nankervis, Susanne C Feil, Nancy C Hancock, Zhaohua Zheng, Hooi-Ling Ng

Bioorg Med Chem Lett· December 2011

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Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.
Lorien J Parker, Louis C Italiano, Craig J Morton, Nancy C Hancock, David B Ascher

Chemistry· July 2011

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The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
Lorien J Parker, Sarah Ciccone, Louis C Italiano, Alessandra Primavera, Aaron J Oakley, Nancy C Hancock

J Mol Biol· June 2008

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Elucidation of the substrate binding site of Siah ubiquitin ligase.
Colin M House, Nancy C Hancock, Andreas Möller, Brett A Cromer, Victor Fedorov

Structure· April 2006

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