Publications by authors named "Natalie Proost"

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Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells.
Muddassir Malik, Willem-Jan de Leeuw, Muhammad Assad Aslam, Eliza Mari Kwesi-Maliepaard, Teun van den Brand, Natalie Proost

Sci Adv· December 2025

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Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective.
Kelly Warmink, Philip Lijnzaad, Stephanie A Schubert, Baojie Zhang, Tristan C W Vermaat, Natalie Proost

JBMR Plus· October 2025

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Large-scale Characterization of Orthotopic Cell Line-Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness.
Catrin Lutz, Xue Chao, Bim de Klein, Jinhyuk Bhin, Madelon Badoux, Natalie Proost

Cancer Res· July 2025

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Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers.
Tim Arnoldus, Alex van Vliet, Onno B Bleijerveld, Adriaan F H de Groot, Qinglin Piao, Natalie Proost

Nat Genet· July 2025

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The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy.
Laura Bornes, Lennart J van Winden, Veerle C M Geurts, Beaunelle de Bruijn, Leyla Azarang, Natalie Proost

Nature· January 2025

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Metabolic profiling of patient-derived organoids reveals nucleotide synthesis as a metabolic vulnerability in malignant rhabdoid tumors.
Marjolein M G Kes, Francisco Morales-Rodriguez, Esther A Zaal, Terezinha de Souza, Natalie Proost

Cell Rep Med· January 2025

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Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation.
Julien Champagne, Morten M Nielsen, Xiaodong Feng, Jasmine Montenegro Navarro, Abhijeet Pataskar, Natalie Proost

Immunity· January 2025

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Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer.
Adva Kochavi, Remco Nagel, Pierre-Rene Körner, Onno B Bleijerveld, Chun-Pu Lin, Natalie Proost

Nucleic Acids Res· December 2024

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ADARp150 counteracts whole genome duplication.
Frank van Gemert, Alexandra Drakaki, Isabel Morales Lozano, Daniël de Groot, Maud Schoot Uiterkamp, Natalie Proost

Nucleic Acids Res· September 2024

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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.
Sander Mertens, Maarten A Huismans, Carla S Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost

Cell Rep· April 2023

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Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.
Katrin J Frank, Antonio Mulero-Sánchez, Alexandra Berninger, Laura Ruiz-Cañas, Astrid Bosma, Natalie Proost

Cell Rep Med· November 2022

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Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.
Daniel Zingg, Jinhyuk Bhin, Julia Yemelyanenko, Sjors M Kas, Frank Rolfs, Natalie Proost

Nature· September 2022

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Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.
Daniel Zingg, Jinhyuk Bhin, Julia Yemelyanenko, Sjors M Kas, Frank Rolfs, Natalie Proost

Nature· August 2022

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Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.
Aldo Spanjaard, Ronak Shah, Daniël de Groot, Olimpia Alessandra Buoninfante, Ben Morris, Natalie Proost

Nucleic Acids Res· July 2022

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Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer.
Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A Huetzen, Jonas Goergens, Natalie Proost

Breast Cancer Res· June 2022

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QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment.
Kaspar Bresser, Meike E W Logtenberg, Mireille Toebes, Natalie Proost, Justin Sprengers

Oncoimmunology· April 2022

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Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer.
Kadi Lõhmussaar, Rurika Oka, Jose Espejo Valle-Inclan, Milou H H Smits, Hila Wardak, Natalie Proost

Cell Stem Cell· August 2021

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SLC1A3 contributes to L-asparaginase resistance in solid tumors.
Jianhui Sun, Remco Nagel, Esther A Zaal, Alejandro Piñeiro Ugalde, Ruiqi Han, Natalie Proost

EMBO J· October 2019

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An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.
Oded Kopper, Chris J de Witte, Kadi Lõhmussaar, Jose Espejo Valle-Inclan, Nizar Hami, Natalie Proost

Nat Med· May 2019

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Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin.
Remco Nagel, Ana Teresa Avelar, Nanne Aben, Natalie Proost, Marieke van de Ven

Mol Cancer Ther· April 2019

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Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors.
Marco Barazas, Alessia Gasparini, Yike Huang, Asli Küçükosmanoğlu, Stefano Annunziato, Natalie Proost

Cancer Res· February 2019

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Long-term expanding human airway organoids for disease modeling.
Norman Sachs, Angelos Papaspyropoulos, Domenique D Zomer-van Ommen, Inha Heo, Lena Böttinger, Natalie Proost

EMBO J· February 2019

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Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
Michela Serresi, Bjorn Siteur, Danielle Hulsman, Carlos Company, Matthias J Schmitt, Natalie Proost

J Exp Med· December 2018

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SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin.
Giustina Ferone, Ji-Ying Song, Kate D Sutherland, Rajith Bhaskaran, Kim Monkhorst, Natalie Proost

Cancer Cell· October 2016

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