Publications by authors named "Natalie Tigue"

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A simeprevir-inducible molecular switch for the control of cell and gene therapies.
Stacey E Chin, Christina Schindler, Lisa Vinall, Roger B Dodd, Lisa Bamber, Natalie J Tigue

Nat Commun· November 2023

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Design and Selection of Heterodimerizing Helical Hairpins for Synthetic Biology.
Abigail J Smith, Elise A Naudin, Caitlin L Edgell, Emily G Baker, Bram Mylemans, Natalie Tigue

ACS Synth Biol· June 2023

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From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles.
Elise A Naudin, Katherine I Albanese, Abigail J Smith, Bram Mylemans, Emily G Baker, Natalie Tigue

Chem Sci· October 2022

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An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag.
Thomas V Murray, Kasia Kozakowska-McDonnell, Adam Tibbles, Annabel Taylor, Daniel Higazi, Natalie Tigue

MAbs· April 2022

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Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody.
Jackie Cheng, Meina Liang, Miguel F Carvalho, Natalie Tigue, Raffaella Faggioni

Antibodies (Basel)· September 2020

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Identification of the cis‑molecular neighbours of the immune checkpoint protein B7‑H4 in the breast cancer cell‑line SK‑BR‑3 by proteomic proximity labelling.
Johanna S Rees, Lawrence C C Cheung, Samir W Hamaia, Gareth Davies, Alan Sandercock, Natalie Tigue

Int J Oncol· July 2020

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Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency.
Christina Schindler, Andie Collinson, Carl Matthews, Amy Pointon, Lesley Jenkinson, Natalie J Tigue

PLoS One· December 2019

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Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo.
Nikki Heath, Xabier Osteikoetxea, Taiana Mia de Oliveria, Elisa Lázaro-Ibáñez, Olga Shatnyeva, Natalie Tigue

Nanomedicine (Lond)· November 2019

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High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles.
Andrea Longatti, Christina Schindler, Andie Collinson, Lesley Jenkinson, Carl Matthews, Natalie Tigue

Nanoscale· August 2018

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Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes.
Luisa Statello, Marco Maugeri, Elena Garre, Muhammad Nawaz, Jessica Wahlgren, Natalie Tigue

PLoS One· July 2018

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Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids.
Gülin Güler-Gane, Sara Kidd, Sudharsan Sridharan, Tristan J Vaughan, Trevor C I Wilkinson, Natalie J Tigue

PLoS One· July 2017

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A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist.
Rebecca Leyland, Amanda Watkins, Kathy A Mulgrew, Nicholas Holoweckyj, Lisa Bamber, Natalie J Tigue

Clin Cancer Res· July 2017

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MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.
Hormas Ghadially, Lee Brown, Chris Lloyd, Leeanne Lewis, Arthur Lewis, Natalie J Tigue

Br J Cancer· April 2017

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MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential.
Natalie J Tigue, Lisa Bamber, John Andrews, Samantha Ireland, James Hair

Oncoimmunology· February 2017

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Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope "tags".
Jennifer L Percival-Alwyn, Elizabeth England, Benjamin Kemp, Laura Rapley, Nicola H E Davis, Natalie J Tigue

MAbs· September 2015

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Evaluation of strategies to control Fab light chain dimer during mammalian expression and purification: A universal one-step process for purification of correctly assembled Fab.
Jennifer Spooner, Jenny Keen, Kalpana Nayyar, Neil Birkett, Nicholas Bond, Natalie Tigue

Biotechnol Bioeng· July 2015

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Use of the site-specific retargeting jump-in platform cell line to support biologic drug discovery.
Robin Butler, David Hornigold, Ling Huang, Catherine Huntington, Tim London, Natalie J Tigue

J Biomol Screen· April 2015

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A high-throughput assay for connexin 43 (Cx43, GJA1) gap junctions using codon-optimized aequorin.
Nazia Haq, David Grose, Emma Ward, Oiyee Chiu, Natalie Tigue

Assay Drug Dev Technol· March 2013

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Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones.
Kerstin Hill, Natalie J Tigue, Rosemary E Kelsell, Christopher D Benham, Shaun McNulty

Neuropharmacology· January 2006

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