Publications by authors named "Neil Maclean"

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SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity.
Enoch Tin, Sergio Rutella, Ismat Khatri, Yoosu Na, Yongran Yan, Neil MacLean

Blood Cancer Discov· May 2025

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The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Geethu Emily Thomas, Grace Egan, Laura García-Prat, Aaron Botham, Veronique Voisin, Neil MacLean

Nat Cell Biol· June 2022

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IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells.
Boaz Nachmias, Dilshad H Khan, Veronique Voisin, Arvind S Mer, Geethu Emily Thomas, Neil Maclean

Leukemia· May 2022

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Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production.
Jong Bok Lee, Dilshad H Khan, Rose Hurren, Mingjing Xu, Yoosu Na, Neil MacLean

Blood· July 2021

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A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.
Samir H Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Neil MacLean

JCI Insight· March 2021

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Novel L-nucleoside analogue, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia.
Aniket Bankar, Thirushi Piyumika Siriwardena, Biljana Rizoska, Christina Rydergård, Helen Kylefjord, Neil Maclean

Haematologica· February 2021

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Transduction of Primary AML Cells with Lentiviral Vector for Study or Engraftment.
Aaron D Schimmer, Rashim Pal Singh, Ayesh K Seneviratne, Geethu E Thomas, Neil MacLean

STAR Protoc· December 2020

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Mitochondrial carrier homolog 2 is necessary for AML survival.
Dilshad H Khan, Michael Mullokandov, Yan Wu, Veronique Voisin, Marcela Gronda, Neil MacLean

Blood· July 2020

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Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Rashim Pal Singh, Danny V Jeyaraju, Veronique Voisin, Rose Hurren, Changjiang Xu, Neil MacLean

Cell Stem Cell· June 2020

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The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.
Sara Mirali, Aaron Botham, Veronique Voisin, Changjiang Xu, Jonathan St-Germain, Neil MacLean

Sci Transl Med· April 2020

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Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
Aaron Botham, Etienne Coyaud, Victor Sanjit Nirmalanandhan, Marcela Gronda, Rose Hurren, Neil Maclean

Proteomics· December 2019

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The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids.
Ayesh K Seneviratne, Mingjing Xu, Juan J Aristizabal Henao, Val A Fajardo, Zhenyue Hao, Neil MacLean

Cell Stem Cell· June 2019

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The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.
Dana Yehudai, Sanduni U Liyanage, Rose Hurren, Biljana Rizoska, Mark Albertella, Neil MacLean

Haematologica· May 2019

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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Jo Ishizawa, Sarah F Zarabi, R Eric Davis, Ondrej Halgas, Takenobu Nii, Neil MacLean

Cancer Cell· May 2019

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The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids.
Ayesh K Seneviratne, Mingjing Xu, Juan J Aristizabal Henao, Val A Fajardo, Zhenyue Hao, Neil MacLean

Cell Stem Cell· April 2019

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Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia.
Samir H Barghout, Parasvi S Patel, Xiaoming Wang, G Wei Xu, Simon Kavanagh, Neil MacLean

Leukemia· January 2019

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Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.
Sanduni U Liyanage, Rose Hurren, Veronique Voisin, Gaëlle Bridon, Xiaoming Wang, Neil MacLean

Blood· May 2017

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Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria.
Sanduni U Liyanage, Etienne Coyaud, Estelle M N Laurent, Rose Hurren, Neil Maclean

Mitochondrion· January 2017

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Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells.
Lianne E Rotin, Neil MacLean, Ahmed Aman, Marcela Gronda, Feng-Hsu Lin

Haematologica· November 2016

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A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia.
Danny V Jeyaraju, Rose Hurren, Xiaoming Wang, Neil MacLean, Marcela Gronda

Oncotarget· August 2016

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Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism.
Lianne E Rotin, Marcela Gronda, Neil MacLean, Rose Hurren, XiaoMing Wang

Oncotarget· January 2016

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Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells.
Yan Wu, Rose Hurren, Neil MacLean, Marcela Gronda, Yulia Jitkova

Apoptosis· August 2015

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Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.
Dannie Bernard, Marinella Gebbia, Swayam Prabha, Marcela Gronda, Neil MacLean

Apoptosis· July 2015

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Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Alicia Cole, Zezhou Wang, Etienne Coyaud, Veronique Voisin, Marcela Gronda, Neil Maclean

Cancer Cell· June 2015

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AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.
Shrivani Sriskanthadevan, Danny V Jeyaraju, Timothy E Chung, Swayam Prabha, Wei Xu, Neil Maclean

Blood· March 2015

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