Publications by authors named "Neil Spector"

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Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.
Dave L Carlson, Mark Kowalewski, Khaldon Bodoor, Adam D Lietzan, Philip F Hughes, Neil Spector

Cell Chem Biol· March 2024

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Visualizing Borrelia burgdorferi Infection Using a Small-Molecule Imaging Probe.
Madeline G Sell, David A Alcorta, Andrew E Padilla, Dakota W Nollner, Nicole R Hasenkampf, Neil L Spector

J Clin Microbiol· June 2021

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Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells.
Angel Y F Kam, Sadhna O Piryani, Chang-Lung Lee, David A Rizzieri, Neil L Spector

Mol Cancer Res· May 2021

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Medical oncologists' perspectives of the Veterans Affairs National Precision Oncology Program.
Vishal Vashistha, Pradeep J Poonnen, Jane L Snowdon, Halcyon G Skinner, Victoria McCaffrey, Neil L Spector

PLoS One· September 2020

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Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program.
Evangelia Katsoulakis, Jill E Duffy, Bradley Hintze, Neil L Spector, Michael J Kelley

JCO Precis Oncol· March 2020

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Genomic Analysis of Metastatic Solid Tumors in Veterans: Findings From the VHA National Precision Oncology Program.
Pradeep J Poonnen, Jill E Duffy, Bradley Hintze, Maulik Shukla, Thomas S Brettin, Neil L Spector

JCO Precis Oncol· August 2019

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A Complete Response After Pseudo-progression: Pembrolizumab for Metastatic Squamous Cell Carcinoma (SCC) of the Bladder.
Chester Kao, Megan McNamara, Chris Alley, Neil Spector, Shekeab Jauhari

Clin Genitourin Cancer· June 2019

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Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium.
Gayathri R Devi, Holly Hough, Nadine Barrett, Massimo Cristofanilli, Beth Overmoyer, Neil Spector

J Cancer· June 2019

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Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.
Takuya Osada, Zachary C Hartman, Junping Wei, Gangjun Lei, Amy C Hobeika, Neil Spector

Breast Cancer Res· August 2018

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Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.
Sadhna O Piryani, Angel Y F Kam, Evelyna G Kliassov, Benny J Chen, Neil L Spector

Stem Cells· February 2018

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X-Ray Psoralen Activated Cancer Therapy (X-PACT).
Mark Oldham, Paul Yoon, Zak Fathi, Wayne F Beyer, Justus Adamson, Neil L Spector

PLoS One· July 2017

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A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo.
Lauren B Crowe, Philip F Hughes, David A Alcorta, Takuya Osada, Aaron P Smith, Neil L Spector

ACS Chem Biol· April 2017

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Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine.
Gerald Goh, Ramona Schmid, Kelly Guiver, Wichit Arpornwirat, Imjai Chitapanarux, Neil Spector

PLoS Med· December 2016

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Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor.
Neil L Spector, Faith C Robertson, Sarah Bacus, Kimberly Blackwell, Deborah A Smith

PLoS One· June 2016

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A role for the androgen receptor in the treatment of male breast cancer.
Jason Zhu, Carter T Davis, Sandra Silberman, Neil Spector, Tian Zhang

Crit Rev Oncol Hematol· February 2016

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CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers.
Linda M Sutton, Joseph Geradts, Erika P Hamilton, Kathleen A Havlin, Gretchen G Kimmick, Neil L Spector

J Natl Compr Canc Netw· August 2015

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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
Matthew K Howe, Khaldon Bodoor, David A Carlson, Philip F Hughes, Yazan Alwarawrah, Neil L Spector

Chem Biol· December 2014

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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.
Wenle Xia, David Gooden, Leihua Liu, Sumin Zhao, Erik J Soderblom, Neil L Spector

PLoS One· October 2014

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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.
Wenle Xia, Emanual F Petricoin, Sumin Zhao, Leihua Liu, Takuya Osada, Neil L Spector

Breast Cancer Res· September 2014

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Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
David A Proia, Chaohua Zhang, Manuel Sequeira, John-Paul Jimenez, Suqin He, Neil Spector

Clin Cancer Res· January 2014

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Pertuzumab protects the achilles' heel of trastuzumab--emtansine.
William R Gwin, Neil L Spector

Clin Cancer Res· January 2014

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Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.
Jared J Barrott, Philip F Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C Hartman, Neil L Spector

Chem Biol· September 2013

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
Manabu Kurokawa, Jiyeon Kim, Joseph Geradts, Kenkyo Matsuura, Liu Liu, Neil L Spector

Sci Signal· May 2013

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Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.
Xiu-Rong Ren, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu, Neil Spector

Breast Cancer Res· June 2012

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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
Qing Cheng, Jeffrey T Chang, Joseph Geradts, Leonard M Neckers, Timothy Haystead, Neil L Spector

Breast Cancer Res· April 2012

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