Publications by authors named "Nicholas Geacintov"

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Hypoxia-dependent recruitment of error-prone DNA polymerases to genome replication.
Ran Yehuda, Ido Dromi, Yishai Levin, Thomas Carell, Nicholas Geacintov

Oncogene· January 2025

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Variable Inhibition of DNA Unwinding Rates Catalyzed by the SARS-CoV-2 Helicase Nsp13 by Structurally Distinct Single DNA Lesions.
Ana H Sales, Iwen Fu, Alexander Durandin, Sam Ciervo, Tania J Lupoli, Nicholas E Geacintov

Int J Mol Sci· July 2024

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Differing structures and dynamics of two photolesions portray verification differences by the human XPD helicase.
Iwen Fu, Nicholas E Geacintov, Suse Broyde

Nucleic Acids Res· December 2023

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Inhibition of RecQ Helicase Activity by Structurally Distinct DNA Lesions: Structure-Function Relationships.
Ana H Sales, Vincent Zheng, Maya A Kenawy, Mark Kakembo, Lu Zhang, Nicholas E Geacintov

Int J Mol Sci· December 2022

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Treatment of Human HeLa Cells with Black Raspberry Extracts Enhances the Removal of DNA Lesions by the Nucleotide Excision Repair Mechanism.
Ana H Sales, Marina Kolbanovskiy, Nicholas E Geacintov, Kun-Ming Chen, Yuan-Wan Sun

Antioxidants (Basel)· October 2022

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Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair.
Iwen Fu, Hong Mu, Nicholas E Geacintov, Suse Broyde

Nucleic Acids Res· July 2022

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Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.
Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nicholas Geacintov

Genome Biol· April 2022

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Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing.
Iwen Fu, Nicholas E Geacintov, Suse Broyde

DNA Repair (Amst)· November 2021

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Recognition and repair of oxidatively generated DNA lesions in plasmid DNA by a facilitated diffusion mechanism.
Marina Kolbanovskiy, Abraham Aharonoff, Ana Helena Sales, Nicholas E Geacintov, Vladimir Shafirovich

Biochem J· June 2021

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TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.
Umakanta Swain, Gilgi Friedlander, Urmila Sehrawat, Avital Sarusi-Portuguez, Ron Rotkopf, Nicholas E Geacintov

Int J Mol Sci· June 2021

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Excision of Oxidatively Generated Guanine Lesions by Competitive DNA Repair Pathways.
Vladimir Shafirovich, Nicholas E Geacintov

Int J Mol Sci· March 2021

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Base and Nucleotide Excision Repair Pathways in DNA Plasmids Harboring Oxidatively Generated Guanine Lesions.
Marina Kolbanovskiy, Abraham Aharonoff, Ana Helena Sales, Nicholas E Geacintov, Vladimir Shafirovich

Chem Res Toxicol· January 2021

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The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion.
Katie M Feher, Alexander Kolbanovskiy, Alexander Durandin, Yoonjung Shim, Jung-Hyun Min, Nicholas E Geacintov

DNA Repair (Amst)· December 2020

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Remarkable Enhancement of Nucleotide Excision Repair of a Bulky Guanine Lesion in a Covalently Closed Circular DNA Plasmid Relative to the Same Linearized Plasmid.
Marina Kolbanovskiy, Abraham Aharonoff, Ana Helena Sales, Nicholas E Geacintov, Vladimir Shafirovich

Biochemistry· August 2020

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Inhibition of Excision of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.
Marina Kolbanovskiy, Yoonjung Shim, Jung-Hyun Min, Nicholas E Geacintov, Vladimir Shafirovich

Biochemistry· May 2020

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Variable impact of conformationally distinct DNA lesions on nucleosome structure and dynamics: Implications for nucleotide excision repair.
Yuqin Cai, Nicholas E Geacintov, Suse Broyde

DNA Repair (Amst)· March 2020

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5-Formylcytosine-induced DNA-peptide cross-links reduce transcription efficiency, but do not cause transcription errors in human cells.
Shaofei Ji, Daeyoon Park, Konstantin Kropachev, Marina Kolbanovskiy, Iwen Fu, Nicholas E Geacintov

J Biol Chem· November 2019

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5',8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance.
Chryssostomos Chatgilialoglu, Carla Ferreri, Nicholas E Geacintov, Marios G Krokidis, Yuan Liu

Cells· May 2019

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Excision of Oxidatively Generated Guanine Lesions by Competing Base and Nucleotide Excision Repair Mechanisms in Human Cells.
Vladimir Shafirovich, Konstantin Kropachev, Marina Kolbanovskiy, Nicholas E Geacintov

Chem Res Toxicol· April 2019

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Nucleotide Excision Repair and Impact of Site-Specific 5',8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes.
Vladimir Shafirovich, Marina Kolbanovskiy, Konstantin Kropachev, Zhi Liu, Yuquin Cai, Nicholas E Geacintov

Biochemistry· February 2019

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Generation of 8-oxo-7,8-dihydroguanine in G-Quadruplexes Models of Human Telomere Sequences by One-electron Oxidation.
Tomasz J Merta, Nicholas E Geacintov, Vladimir Shafirovich

Photochem Photobiol· January 2019

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Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair.
Hong Mu, Nicholas E Geacintov, Suse Broyde, Jung-Eun Yeo, Orlando D Schärer

DNA Repair (Amst)· November 2018

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Lesion Sensing during Initial Binding by Yeast XPC/Rad4: Toward Predicting Resistance to Nucleotide Excision Repair.
Hong Mu, Yingkai Zhang, Nicholas E Geacintov, Suse Broyde

Chem Res Toxicol· November 2018

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Synergistic effects of H3 and H4 nucleosome tails on structure and dynamics of a lesion-containing DNA: Binding of a displaced lesion partner base to the H3 tail for GG-NER recognition.
Yuqin Cai, Iwen Fu, Nicholas E Geacintov, Yingkai Zhang, Suse Broyde

DNA Repair (Amst)· May 2018

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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.
Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nicholas Geacintov

Genome Biol· March 2018

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