Publications by authors named "Nicole Goodwin"

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Copper-Nitroxyl-Catalyzed α-Oxygenation of Cyclic Secondary Amines Including Application to Late-Stage Functionalization.
Christopher M Hanneman, Jack Twilton, Melissa N Hall, Nicole C Goodwin, Jennifer M Elward

J Am Chem Soc· May 2024

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Empowering Voices: Inspiring Women in Medicinal Chemistry.
Maria-Jesus Blanco, Joanne J Bronson, Erin F DiMauro, Carolyn Dzierba, MariJean Eggen, Nicole C Goodwin

ACS Med Chem Lett· April 2024

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Empowering Voices: Inspiring Women in Medicinal Chemistry.
Maria-Jesus Blanco, Joanne J Bronson, Erin F DiMauro, Carolyn Dzierba, MariJean Eggen, Nicole C Goodwin

J Med Chem· March 2024

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Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Linda S Barton, James F Callahan, Juan Cantizani, Nestor O Concha, Ignacio Cotillo Torrejon, Nicole C Goodwin

Bioorg Med Chem· February 2024

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Design and Characterization of 1,3-Dihydro-2-benzo[]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.
Paul Bamborough, Chun-Wa Chung, Nicole C Goodwin, Darren J Mitchell, Christopher E Neipp

ACS Med Chem Lett· September 2023

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Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).
Jane Aldrich, Shelley Allen, Erika Araujo, Joanne Bronson, Amanda Bryant-Friedrich, Nicole C Goodwin

ACS Med Chem Lett· April 2023

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Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).
Jane Aldrich, Shelley Allen, Erika Araujo, Joanne Bronson, Amanda Bryant-Friedrich, Nicole C Goodwin

J Med Chem· March 2023

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Persistence Pays Off: Milvexian Emerges from the Industry's Longstanding Search for Orally Bioavailable Factor XIa Inhibitors.
Nicole C Goodwin

J Med Chem· February 2022

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Site-Selective C-H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis.
Joshua B McManus, Nicholas P R Onuska, Matthew S Jeffreys, Nicole C Goodwin, David A Nicewicz

Org Lett· January 2020

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
Curt D Haffner, Adam K Charnley, Christopher J Aquino, Linda Casillas, Máire A Convery, Nicole C Goodwin

ACS Med Chem Lett· November 2019

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Biocatalysis in Medicinal Chemistry: Challenges to Access and Drivers for Adoption.
Nicole C Goodwin, James P Morrison, Douglas E Fuerst, Timin Hadi

ACS Med Chem Lett· October 2019

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LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice.
David R Powell, Melinda G Smith, Deon D Doree, Angela L Harris, Jennifer Greer, Nicole C Goodwin

J Pharmacol Exp Ther· July 2017

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Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.
Nicole C Goodwin, Zhi-Ming Ding, Bryce A Harrison, Eric D Strobel, Angela L Harris

J Med Chem· January 2017

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Ischemic preconditioning, retinal neuroprotection and histone deacetylase activities.
Jie Fan, Oday Alsarraf, C James Chou, Phillip W Yates, Nicole C Goodwin

Exp Eye Res· May 2016

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Impact of transcutaneous neuromuscular electrical stimulation on dysphagia in patients with head and neck cancer treated with definitive chemoradiation.
Aashish D Bhatt, Nicole Goodwin, Elizabeth Cash, Geetika Bhatt, Craig L Silverman

Head Neck· July 2015

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LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2.
David R Powell, Melinda G Smith, Deon D Doree, Angela L Harris, Wendy W Xiong, Nicole C Goodwin

Pharmacol Res Perspect· March 2015

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Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.
Nicole C Goodwin, Giovanni Cianchetta, Hugh A Burgoon, Jason Healy, Ross Mabon

ACS Med Chem Lett· January 2015

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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.
Bryce A Harrison, Zheng Y Almstead, Hugh Burgoon, Michael Gardyan, Nicole C Goodwin

ACS Med Chem Lett· January 2015

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Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Nicole C Goodwin, Ross Mabon, Bryce A Harrison, Melanie K Shadoan, Zheng Y Almstead

J Med Chem· October 2009

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The first enantioselective organocatalytic Mukaiyama-Michael reaction: a direct method for the synthesis of enantioenriched gamma-butenolide architecture.
Sean P Brown, Nicole C Goodwin, David W C MacMillan

J Am Chem Soc· February 2003

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