Publications by authors named "Oliver Burk"

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Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liver.
Kathrin Klein, Oliver Burk, Roman Tremmel, Florian A Buettner, Lea Kaestle

Pharmacol Res· November 2025

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Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Nodes.
Haralampos Tzoupis, Michail Papadourakis, Konstantinos D Papavasileiou, Oliver Burk, Volker M Lauschke

J Chem Inf Model· November 2025

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Circulating metabolite signatures indicate differential gut-liver crosstalk in lean and obese MASLD.
Mathias Haag, Stefan Winter, Aurino M Kemas, Julia Tevini, Alexandra Feldman, Oliver Burk

JCI Insight· April 2025

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The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Oliver Burk

Nat Commun· February 2025

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Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist.
Azam Rashidian, Enni-Kaisa Mustonen, Thales Kronenberger, Matthias Schwab, Oliver Burk

Comput Struct Biotechnol J· June 2022

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Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR.
Steffen Hirte, Oliver Burk, Ammar Tahir, Matthias Schwab, Björn Windshügel

Cells· April 2022

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Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library.
Enni-Kaisa Mustonen, Tatu Pantsar, Azam Rashidian, Juliander Reiner, Matthias Schwab, Oliver Burk

Cells· April 2022

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Identification and characterization of novel splice variants of human farnesoid X receptor.
Enni-Kaisa Mustonen, Serene M L Lee, Hanno Nieß, Matthias Schwab, Tatu Pantsar, Oliver Burk

Arch Biochem Biophys· July 2021

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Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor.
Oliver Burk, Thales Kronenberger, Oliver Keminer, Serene M L Lee, Tobias S Schiergens

Mol Pharmacol· March 2021

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Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3.
Oliver Keminer, Björn Windshügel, Frank Essmann, Serene M L Lee, Tobias S Schiergens, Oliver Burk

Arch Toxicol· August 2019

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Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.
Oliver Burk, Maria Kuzikov, Thales Kronenberger, Judith Jeske, Oliver Keminer

Arch Toxicol· April 2018

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Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.
Judith Jeske, Andreas Bitter, Wolfgang E Thasler, Thomas S Weiss, Matthias Schwab, Oliver Burk

Biochem Pharmacol· July 2017

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Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.
Judith Jeske, Björn Windshügel, Wolfgang E Thasler, Matthias Schwab, Oliver Burk

Arch Toxicol· June 2017

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Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.
Benjamin A Kandel, Maria Thomas, Stefan Winter, Georg Damm, Daniel Seehofer, Oliver Burk

Biochim Biophys Acta· September 2016

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Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor.
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn

PLoS One· May 2016

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Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.
Andreas Bitter, Petra Rümmele, Kathrin Klein, Benjamin A Kandel, Jessica K Rieger, Oliver Burk

Arch Toxicol· November 2015

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Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.
Andreas Bitter, Andreas K Nüssler, Wolfgang E Thasler, Kathrin Klein, Ulrich M Zanger, Oliver Burk

Cell Physiol Biochem· October 2015

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Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn

PLoS One· July 2015

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Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor.
Rita Piedade, Stefanie Traub, Andreas Bitter, Andreas K Nüssler, José P Gil, Oliver Burk

Antimicrob Agents Chemother· January 2015

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Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.
Anne T Nies, Mikko Niemi, Oliver Burk, Stefan Winter, Ulrich M Zanger

Genome Med· May 2014

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Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).
Maria Thomas, Oliver Burk, Britta Klumpp, Benjamin A Kandel, Georg Damm

Mol Pharmacol· March 2013

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PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin.
Rita Piedade, Elke Schaeffeler, Stefan Winter, Sara Asimus, Matthias Schwab, Oliver Burk

Antimicrob Agents Chemother· April 2012

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Evolutionary history and functional characterization of the amphibian xenosensor CAR.
Marianne Mathäs, Oliver Burk, Huan Qiu, Christian Nusshag, Ute Gödtel-Armbrust

Mol Endocrinol· January 2012

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Inferring statin-induced gene regulatory relationships in primary human hepatocytes.
Adrian Schröder, Johannes Wollnik, Clemens Wrzodek, Andreas Dräger, Michael Bonin, Oliver Burk

Bioinformatics· September 2011

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Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
Monica A Istrate, Andreas K Nussler, Michel Eichelbaum, Oliver Burk

Biochem Biophys Res Commun· March 2010

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