Publications by authors named "Paige Mahaney"

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Development of an asymmetric synthesis of a chiral quaternary FLAP inhibitor.
Keith R Fandrick, Jason A Mulder, Nitinchandra D Patel, Joe Gao, Michael Konrad, Paige E Mahaney

J Org Chem· February 2015

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Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi, Todd Bosanac, Valentina Berger, Paige E Mahaney

J Med Chem· February 2015

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Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.
Ramakanth Sarabu, Fred T Bizzarro, Wendy L Corbett, Mark T Dvorozniak, Wanping Geng, Paige E Mahaney

J Med Chem· August 2012

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Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.
Lori K Gavrin, Paige E Mahaney, Douglas Jenkins, Lisa M Nogle, Cheryl A Mugford

ACS Med Chem Lett· June 2010

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Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
Joseph P Sabatucci, Paige E Mahaney, Jennifer Leiter, Grace Johnston, Kevin Burroughs

Bioorg Med Chem Lett· May 2010

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Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).
Nancy-Ellen Haynes, Wendy L Corbett, Fred T Bizzarro, Kevin R Guertin, Darryl W Hilliard, Paige E Mahaney

J Med Chem· May 2010

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1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
An T Vu, Stephen T Cohn, Puwen Zhang, Callain Y Kim, Paige E Mahaney

J Med Chem· March 2010

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Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates.
Joseph T Lundquist, Douglas C Harnish, Callain Y Kim, John F Mehlmann, Rayomand J Unwalla, Paige E Mahaney

J Med Chem· February 2010

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Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
Gavin D Heffernan, Richard D Coghlan, Eric S Manas, Robert E McDevitt, Yanfang Li, Paige E Mahaney

Bioorg Med Chem· November 2009

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Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.
Paige E Mahaney, Callain Y Kim, Richard D Coghlan, Stephen T Cohn, Gavin D Heffernan

Bioorg Med Chem Lett· October 2009

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Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
Callain Y Kim, Paige E Mahaney, Oliver McConnell, Yingru Zhang, Eric Manas

Bioorg Med Chem Lett· September 2009

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Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR).
John F Mehlmann, Matthew L Crawley, Joseph T Lundquist, Ray J Unwalla, Douglas C Harnish, Paige E Mahaney

Bioorg Med Chem Lett· September 2009

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1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
Puwen Zhang, Eugene A Terefenko, Jenifer Bray, Darlene Deecher, Andrew Fensome, Paige E Mahaney

J Med Chem· September 2009

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3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
An T Vu, Stephen T Cohn, Eugene A Terefenko, William J Moore, Puwen Zhang, Paige E Mahaney

Bioorg Med Chem Lett· May 2009

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A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia.
Mark J Evans, Paige E Mahaney, Lisa Borges-Marcucci, KehDih Lai, Shuguang Wang

Am J Physiol Gastrointest Liver Physiol· March 2009

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Efficient, regioselective palladium-catalyzed tandem Heck-isomerization reaction of aryl bromides and non-allylic benzyl alcohols.
Matthew L Crawley, Kristin M Phipps, Igor Goljer, John F Mehlmann, Joseph T Lundquist, Paige E Mahaney

Org Lett· March 2009

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Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).
Brenton Flatt, Richard Martin, Tie-Lin Wang, Paige Mahaney, Brett Murphy

J Med Chem· February 2009

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Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.
Puwen Zhang, Eugene A Terefenko, Casey C McComas, Paige E Mahaney, An Vu

Bioorg Med Chem Lett· December 2008

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Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
Casey C McComas, An T Vu, Paige E Mahaney, Stephen T Cohn, Andrew Fensome

Bioorg Med Chem Lett· September 2008

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Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Paige E Mahaney, Lori K Gavrin, Eugene J Trybulski, Gary P Stack, T An Vu

J Med Chem· July 2008

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Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.
John N Mason, Darlene C Deecher, Rhonda L Richmond, Gary Stack, Paige E Mahaney

J Pharmacol Exp Ther· November 2007

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Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.
Paige E Mahaney, An T Vu, Casey C McComas, Puwen Zhang, Lisa M Nogle

Bioorg Med Chem· December 2006

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Regioselective synthesis of substituted pyrroles: efficient palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylate derivatives.
Matthew L Crawley, Igor Goljer, Douglas J Jenkins, John F Mehlmann, Lisa Nogle, Paige E Mahaney

Org Lett· December 2006

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Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: hydroxybenzoyl-3,4-dihydroquinoxalin-2(1H)-ones.
Paige E Mahaney, Michael B Webb, Fei Ye, Joseph P Sabatucci, Robert J Steffan

Bioorg Med Chem· May 2006

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Allosteric activators of glucokinase: potential role in diabetes therapy.
Joseph Grimsby, Ramakanth Sarabu, Wendy L Corbett, Nancy-Ellen Haynes, Fred T Bizzarro, Paige E Mahaney

Science· July 2003

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