Publications by authors named "Pascal Grondin"

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Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection.
Philippe Karoyan, Vincent Vieillard, Luis Gómez-Morales, Estelle Odile, Amélie Guihot, Pascal Grondin

Commun Biol· February 2021

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Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells.
Thomas Denèfle, Elodie Pramil, Luis Gómez-Morales, Mikail D Levasseur, Eva Lardé, Pascal Grondin

J Med Chem· September 2019

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Philip A Harris, Nicolas Faucher, Nicolas George, Patrick M Eidam, Bryan W King, Pascal Grondin

J Med Chem· May 2019

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A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes.
Fatima-Zohra Boufroura, Carole Le Bachelier, Céline Tomkiewicz-Raulet, Dimitri Schlemmer, Jean-François Benoist, Pascal Grondin

Hum Mol Genet· October 2018

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Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA).
Alison J-A Woolford, Philip J Day, Véronique Bénéton, Valerio Berdini, Joseph E Coyle, Pascal Grondin

J Med Chem· December 2016

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Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.
Thomas Denèfle, Héloise Boullet, Linda Herbi, Clara Newton, Ana-Carolina Martinez-Torres, Pascal Grondin

J Med Chem· September 2016

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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
Alison J-A Woolford, Joseph E Pero, Sridhar Aravapalli, Valerio Berdini, Joseph E Coyle, Pascal Grondin

J Med Chem· June 2016

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Discovery of Pyridones As Oral AMPK Direct Activators.
Olivier Mirguet, Stéphane Sautet, Catherine-Anne Clément, Jérôme Toum, Frédéric Donche, Pascal Grondin

ACS Med Chem Lett· July 2013

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Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.
Melissa H Costell, Nicolas Ancellin, Roberta E Bernard, Shufang Zhao, John J Upson, Pascal Grondin

Front Pharmacol· October 2012

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade.
Matthew J Sanders, Pascal O Grondin, Bronwyn D Hegarty, Michael A Snowden, David Carling

Biochem J· April 2007

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Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine.
Jean-Marie Brusq, Nicolas Ancellin, Pascal Grondin, Raphaelle Guillard, Sandrine Martin

J Lipid Res· June 2006

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Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.
Marc Foretz, Nicolas Ancellin, Fabrizio Andreelli, Yannick Saintillan, Pascal Grondin

Diabetes· May 2005

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The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.
Alain Daugan, Pascal Grondin, Cécile Ruault, Anne-Charlotte Le Monnier de Gouville, Hervé Coste

J Med Chem· October 2003

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The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.
Alain Daugan, Pascal Grondin, Cécile Ruault, Anne-Charlotte Le Monnier de Gouville, Hervé Coste

J Med Chem· October 2003

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