Publications by authors named "Pascal Kusters"

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Accelerated atherosclerosis associated with immune checkpoint inhibitors: a systematic review and meta-analysis of pre-clinical studies.
Anniek Strijdhorst, Winnie G Vos, Laura A Bosmans, Kim E Dzobo, Pascal J H Kusters

Atherosclerosis· June 2025

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Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis.
Bram W van Os, Pascal J H Kusters, Myrthe den Toom, Linda Beckers, Claudia M van Tiel

Front Cardiovasc Med· May 2023

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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.
Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Pascal J H Kusters

Nat Commun· June 2021

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The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease.
Laura A Bosmans, Lena Bosch, Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens

J Cardiovasc Transl Res· February 2021

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Immune Checkpoint Inhibitor Therapy Aggravates T Cell-Driven Plaque Inflammation in Atherosclerosis.
Kikkie Poels, Mandy M T van Leent, Celine Boutros, Hubert Tissot, Séverine Roy, Pascal J H Kusters

JACC CardioOncol· November 2020

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Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
Annelie Shami, Dorothee Atzler, Laura A Bosmans, Holger Winkels, Svenja Meiler, Pascal Kusters

Eur Heart J· August 2020

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Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice.
Kikkie Poels, Mandy M T van Leent, Myrthe E Reiche, Pascal J H Kusters, Stephan Huveneers

Cells· August 2020

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Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.
Pei-Yu Chen, Lingfeng Qin, Guangxin Li, Zheng Wang, James E Dahlman, Pascal Kusters

Nat Metab· September 2019

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Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.
Suzanne Abm Aarts, Tom Tp Seijkens, Pascal Jh Kusters, Claudia M van Tiel, Myrthe E Reiche

J Pathol· April 2019

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Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.
Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters

Eur Heart J· January 2019

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CD40L Deficiency Protects Against Aneurysm Formation.
Pascal J H Kusters, Tom T P Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels

Arterioscler Thromb Vasc Biol· May 2018

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Exploring immune checkpoints as potential therapeutic targets in atherosclerosis.
Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens

Cardiovasc Res· March 2018

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Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.
Tom T P Seijkens, Claudia M van Tiel, Pascal J H Kusters, Dorothee Atzler, Oliver Soehnlein

J Am Coll Cardiol· February 2018

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Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption.
Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels

Am J Pathol· December 2017

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Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils.
Susan M van den Berg, Andrea D van Dam, Pascal J H Kusters, Linda Beckers, Myrthe den Toom

J Mol Endocrinol· October 2017

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Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.
Yvonne Döring, Heidi Noels, Emiel P C van der Vorst, Carlos Neideck, Virginia Egea, Pascal J H Kusters

Circulation· July 2017

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Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.
Suzanne A B M Aarts, Tom T P Seijkens, Pascal J H Kusters, Susanne M A van der Pol, Barbara Zarzycka

J Neuroinflammation· May 2017

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Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity.
Quinte Braster, Carlos Silvestre-Roig, Helene Hartwig, Pascal Kusters, Suzanne Aarts

Thromb Haemost· June 2016

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Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.
Susan M van den Berg, Tom T P Seijkens, Pascal J H Kusters, Linda Beckers, Myrthe den Toom

FASEB J· May 2016

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Cytokines and Immune Responses in Murine Atherosclerosis.
Pascal J H Kusters, Esther Lutgens

Methods Mol Biol· April 2016

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Duodenal perforation following bile duct endoprosthesis placement.
Pascal J H Kusters, Eric T P Keulen, Frank P J Peters

Endoscopy· September 2015

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Immune cell crosstalk in obesity: a key role for costimulation?
Tom Seijkens, Pascal Kusters, Antonios Chatzigeorgiou, Triantafyllos Chavakis, Esther Lutgens

Diabetes· December 2014

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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
Antonios Chatzigeorgiou, Tom Seijkens, Barbara Zarzycka, David Engel, Marjorie Poggi, Pascal Kusters

Proc Natl Acad Sci U S A· February 2014

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CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications.
Tom Seijkens, Pascal Kusters, David Engel, Esther Lutgens

Diab Vasc Dis Res· March 2013

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