Publications by authors named "Patrick Bulau"

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Mass spectrometry-based multi-attribute method in protein therapeutics product quality monitoring and quality control.
Feng Yang, Jennifer Zhang, Alexander Buettner, Eva Vosika, Monica Sadek, Patrick Bulau

MAbs· April 2023

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Identification of Hetero-aggregates in Antibody Co-formulations by Multi-dimensional Liquid Chromatography Coupled to Mass Spectrometry.
Felix Kuhne, Katrin Heinrich, Martin Winter, Jürgen Fichtl, Gabriel Hoffmann, Patrick Bulau

Anal Chem· January 2023

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Comprehensive Multidimensional Liquid Chromatography-Mass Spectrometry for the Characterization of Charge Variants of a Bispecific Antibody.
Ingrid Grunert, Katrin Heinrich, Michael Hingar, Juliane Ernst, Martin Winter, Patrick Bulau

J Am Soc Mass Spectrom· December 2022

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Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability.
Ingrid Grunert, Katrin Heinrich, Juliane Ernst, Michael Hingar, Alexandre Briguet, Patrick Bulau

ACS Omega· February 2022

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Quantifying methionine sulfoxide in therapeutic protein formulation excipients as sensitive oxidation marker.
Arnaud Fevre, Steffen Kiessig, Lea Bonnington, Jan Olaf Stracke, Patrick Bulau

J Chromatogr B Analyt Technol Biomed Life Sci· January 2022

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Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS.
Julien Camperi, Ingrid Grunert, Katrin Heinrich, Martin Winter, Saban Özipek, Patrick Bulau

Talanta· November 2021

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Multiattribute Monitoring of Antibody Charge Variants by Cation-Exchange Chromatography Coupled to Native Mass Spectrometry.
Markus Haberger, Anna-Katharina Heidenreich, Michaela Hook, Jürgen Fichtl, Rainer Lang, Patrick Bulau

J Am Soc Mass Spectrom· August 2021

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Recent advances in LC-MS based characterization of protein-based bio-therapeutics - mastering analytical challenges posed by the increasing format complexity.
Tobias Graf, Katrin Heinrich, Ingrid Grunert, Harald Wegele, Markus Haberger, Patrick Bulau

J Pharm Biomed Anal· July 2020

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Multi-Attribute Monitoring of Complex Erythropoetin Beta Glycosylation by GluC Liquid Chromatography-Mass Spectrometry Peptide Mapping.
Alexander Buettner, Maria Maier, Lea Bonnington, Patrick Bulau, Dietmar Reusch

Anal Chem· June 2020

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Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics.
Oksana Tyshchuk, Christoph Gstöttner, Dennis Funk, Simone Nicolardi, Stefan Frost, Patrick Bulau

MAbs· October 2019

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The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange.
Felix Kuhne, Lea Bonnington, Sebastian Malik, Marco Thomann, Cecile Avenal, Patrick Bulau

Antibodies (Basel)· October 2019

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Effects of sialic acid linkage on antibody-fragment crystallizable receptor binding and antibody dependent cytotoxicity depend on levels of fucosylation/bisecting.
Marco Thomann, Sebastian Malik, Felix Kuhne, Cecile Avenal, Friederike Plath, Patrick Bulau

Bioanalysis· August 2019

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Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions.
Ingrid Schmid, Lea Bonnington, Monika Gerl, Katrin Bomans, Anna Louisa Thaller, Patrick Bulau

Commun Biol· April 2018

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Application of Hydrogen/Deuterium Exchange-Mass Spectrometry to Biopharmaceutical Development Requirements: Improved Sensitivity to Detection of Conformational Changes.
Lea Bonnington, Ingo Lindner, Ulrich Gilles, Tobias Kailich, Dietmar Reusch, Patrick Bulau

Anal Chem· August 2017

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Affinity purification of erythropoietin from cell culture supernatant combined with MALDI-TOF-MS analysis of erythropoietin N-glycosylation.
David Falck, Markus Haberger, Rosina Plomp, Michaela Hook, Patrick Bulau

Sci Rep· July 2017

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Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry.
Rabah Gahoual, Anna-Katharina Heidenreich, Govert W Somsen, Patrick Bulau, Dietmar Reusch

Anal Chem· May 2017

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Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.
Björn Boll, Juliana Bessa, Emilien Folzer, Anacelia Ríos Quiroz, Roland Schmidt, Patrick Bulau

Mol Pharm· April 2017

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Detection of a phosphorylated glycine-serine linker in an IgG-based fusion protein.
Oksana Tyshchuk, Hans Rainer Völger, Claudia Ferrara, Patrick Bulau, Hans Koll

MAbs· January 2017

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Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry.
Markus Haberger, Michael Leiss, Anna-Katharina Heidenreich, Oxana Pester, Georg Hafenmair, Patrick Bulau

MAbs· December 2016

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Applying mini-bore HPAEC-MS/MS for the characterization and quantification of Fc N-glycans from heterogeneously glycosylated IgGs.
Maria Maier, Dietmar Reusch, Cees Bruggink, Patrick Bulau, Manfred Wuhrer

J Chromatogr B Analyt Technol Biomed Life Sci· October 2016

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Functional assessment of antibody oxidation by native mass spectrometry.
Markus Haberger, Anna-Katharina Heidenreich, Tilman Schlothauer, Michaela Hook, Jana Gassner, Patrick Bulau

MAbs· June 2016

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In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity.
Marco Thomann, Tilman Schlothauer, Tetyana Dashivets, Sebastian Malik, Cecile Avenal, Patrick Bulau

PLoS One· May 2016

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Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles-Part 2: Mass spectrometric methods.
Dietmar Reusch, Markus Haberger, David Falck, Britta Peter, Bernd Maier, Patrick Bulau

MAbs· March 2016

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Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles--part 1: separation-based methods.
Dietmar Reusch, Markus Haberger, Bernd Maier, Maria Maier, Ronny Kloseck, Patrick Bulau

MAbs· September 2015

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Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule.
Emilien Folzer, Katharina Diepold, Katrin Bomans, Christof Finkler, Roland Schmidt, Patrick Bulau

J Pharm Sci· September 2015

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