Publications by authors named "Patrick Cushing"

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Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context.
Jeanine F Amacher, Patrick R Cushing, Lars Vouilleme, Sierra N Cullati, Bin Deng

J Mol Biol· December 2025

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Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context.
Jeanine F Amacher, Patrick R Cushing, Lars Vouilleme, Sierra N Cullati, Bin Deng

bioRxiv· September 2025

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Mobile Health (mHealth) Use or Non-Use by Residents of West Virginia.
Peter Giacobbi, Patrick Cushing, Alexis Popa, Treah Haggerty, Adam Hansell

South Med J· October 2018

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Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Yu Zhao, Patrick R Cushing, David C Smithson, Maria Pellegrini, Alexandre A Pletnev

Biosci Rep· August 2018

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Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain.
Yu Zhao, Patrick R Cushing, David C Smithson, Maria Pellegrini, Alexandre A Pletnev

Biosci Rep· August 2018

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Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction.
Jeremy M Fitzpatrick, Maria Pellegrini, Patrick R Cushing, Dale F Mierke

Biochemistry· September 2014

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Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses.
Jeanine F Amacher, Patrick R Cushing, Lionel Brooks, Prisca Boisguerin, Dean R Madden

Structure· January 2014

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Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.
Jeanine F Amacher, Patrick R Cushing, Christopher D Bahl, Tobias Beck, Dean R Madden

J Biol Chem· February 2013

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Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity.
Kyle E Roberts, Patrick R Cushing, Prisca Boisguerin, Dean R Madden, Bruce R Donald

PLoS Comput Biol· August 2012

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Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.
Rituparna Kundu, Patrick R Cushing, Brian V Popp, Yu Zhao, Dean R Madden

Angew Chem Int Ed Engl· July 2012

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Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor.
Jeanine F Amacher, Patrick R Cushing, Joshua A Weiner, Dean R Madden

Acta Crystallogr Sect F Struct Biol Cryst Commun· May 2011

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Engineering peptide inhibitors to overcome PDZ binding promiscuity.
Lars Vouilleme, Patrick R Cushing, Rudolf Volkmer, Dean R Madden, Prisca Boisguerin

Angew Chem Int Ed Engl· December 2010

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A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.
Patrick R Cushing, Lars Vouilleme, Maria Pellegrini, Prisca Boisguerin, Dean R Madden

Angew Chem Int Ed Engl· December 2010

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The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.
Patrick R Cushing, Abigail Fellows, Daniel Villone, Prisca Boisguérin, Dean R Madden

Biochemistry· September 2008

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Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.
Christina J Matheny, Maren E Speck, Patrick R Cushing, Yunpeng Zhou, Takeshi Corpora

EMBO J· February 2007

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