Publications by authors named "Patrick Strout"

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Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
Jason B White, Ryan Fleming, Luke Masterson, Ben T Ruddle, Haihong Zhong, Patrick Strout

MAbs· April 2019

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Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
Song Cho, Francesca Zammarchi, David G Williams, Carin E G Havenith, Noel R Monks, Patrick Strout

Mol Cancer Ther· October 2018

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Generation of a functional humanized Delta-like ligand 4 transgenic mouse model.
John Wiseman, Pernilla Gregersson, Johan Johansson, Kerstin Magnell, Fernanda Pilataxi, Patrick Strout

Transgenic Res· December 2017

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Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.
Jay Harper, Christopher Lloyd, Nazzareno Dimasi, Dorin Toader, Rose Marwood, Patrick Strout

Mol Cancer Ther· August 2017

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Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies.
Jonathan Rios-Doria, Jay Harper, Raymond Rothstein, Leslie Wetzel, Jon Chesebrough, Patrick Strout

Cancer Res· May 2017

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Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics.
Pamela Thompson, Ryan Fleming, Binyam Bezabeh, Fengying Huang, Shenlan Mao, Patrick Strout

J Control Release· August 2016

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Hydrolytically Stable Site-Specific Conjugation at the N-Terminus of an Engineered Antibody.
Pamela Thompson, Binyam Bezabeh, Ryan Fleming, Monica Pruitt, Shenlan Mao, Patrick Strout

Bioconjug Chem· October 2015

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Selecting an optimal antibody for antibody-drug conjugate therapy: internalization and intracellular localization.
Jay Harper, Shenlan Mao, Patrick Strout, Adeela Kamal

Methods Mol Biol· February 2014

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