Publications by authors named "Dorin Toader"

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PBPK Modeling to Predict Clinical Drug-Drug Interaction and Impact of Hepatic Impairment for an ADC With the Payload Auristatin F-Hydroxypropylamide.
Niyanta Kumar, Vaishali Dixit, Howard Burt, Katherine L Gill, Hannah M Jones, Dorin Toader

CPT Pharmacometrics Syst Pharmacol· October 2025

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XMT-2056, a HER2-Directed STING Agonist Antibody-Drug Conjugate, Induces Innate Antitumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells.
Raghida A Bukhalid, Jeremy R Duvall, Kelly Lancaster, Kalli C Catcott, Naniye Malli Cetinbas, Dorin Toader

Clin Cancer Res· May 2025

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Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses.
Naniye Malli Cetinbas, Travis Monnell, Jahna Soomer-James, Pamela Shaw, Kelly Lancaster, Dorin Toader

Nat Commun· July 2024

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Development of a Novel DNA Mono-alkylator Platform for Antibody-Drug Conjugates.
Joshua D Thomas, Aleksandr V Yurkovetskiy, Mao Yin, Natalya D Bodyak, Shuyi Tang, Dorin Toader

Mol Cancer Ther· April 2024

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Site-Specific Dolasynthen Antibody-Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios.
Susan M Clardy, Alex Uttard, Bingfan Du, Kalli C Catcott, Kelly L Lancaster, Dorin Toader

Mol Cancer Ther· January 2024

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Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer.
Dorin Toader, Shawn P Fessler, Scott D Collins, Patrick R Conlon, Reddy Bollu

Mol Cancer Ther· September 2023

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Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.
Jeremy R Duvall, Joshua D Thomas, Raghida A Bukhalid, Kalli C Catcott, Keith W Bentley, Dorin Toader

J Med Chem· August 2023

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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.
John Y Li, Samuel R Perry, Vanessa Muniz-Medina, Xinzhong Wang, Leslie K Wetzel, Dorin Toader

Cancer Cell· June 2019

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
Neil P Grimster, Erica Anderson, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Dorin Toader

J Med Chem· June 2018

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Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
Bin Yang, Melissa M Vasbinder, Alexander W Hird, Qibin Su, Haixia Wang, Dorin Toader

J Med Chem· February 2018

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Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.
Jay Harper, Christopher Lloyd, Nazzareno Dimasi, Dorin Toader, Rose Marwood

Mol Cancer Ther· August 2017

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Structure-Cytotoxicity Relationships of Analogues of N-Desacetoxytubulysin H.
Dorin Toader, Fengjiang Wang, Lakshmaiah Gingipalli, Melissa Vasbinder, Mark Roth

J Med Chem· December 2016

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Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates.
Pamela Thompson, Ebele Ezeadi, Ian Hutchinson, Ryan Fleming, Binyam Bezabeh, Dorin Toader

ACS Med Chem Lett· November 2016

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Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Melissa M Vasbinder, Marat Alimzhanov, Martin Augustin, Geraldine Bebernitz, Kirsten Bell, Dorin Toader

Bioorg Med Chem Lett· January 2016

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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.
John Y Li, Samuel R Perry, Vanessa Muniz-Medina, Xinzhong Wang, Leslie K Wetzel, Dorin Toader

Cancer Cell· January 2016

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Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.
Jiaquan Wu, Francoise Powell, Nicholas A Larsen, Zhongwu Lai, Kate F Byth, Dorin Toader

ACS Chem Biol· March 2013

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Essential role of TAK1 in regulating mantle cell lymphoma survival.
Daniela Buglio, Sangeetha Palakurthi, Kate Byth, Francisco Vega, Dorin Toader

Blood· July 2012

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Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.
Vibha Oza, Susan Ashwell, Lynsie Almeida, Patrick Brassil, Jason Breed, Dorin Toader

J Med Chem· June 2012

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Structural approaches to obtain kinase selectivity.
Richard A Norman, Dorin Toader, Andrew D Ferguson

Trends Pharmacol Sci· May 2012

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Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Vibha Oza, Susan Ashwell, Patrick Brassil, Jason Breed, Jaychandran Ezhuthachan, Dorin Toader

Bioorg Med Chem Lett· March 2012

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Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.
Vibha Oza, Susan Ashwell, Patrick Brassil, Jason Breed, Chun Deng, Dorin Toader

Bioorg Med Chem Lett· September 2010

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Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
James W Janetka, Lynsie Almeida, Susan Ashwell, Patrick J Brassil, Kevin Daly, Dorin Toader

Bioorg Med Chem Lett· July 2008

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Structure-based design of protein tyrosine phosphatase-1B inhibitors.
Emma Black, Jason Breed, Alexander L Breeze, Kevin Embrey, Robert Garcia, Dorin Toader

Bioorg Med Chem Lett· May 2005

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A Four-Carbon Unit Reagent for the Regiospecific Synthesis of 2-Alkyl-Substituted 1,3-Butadienes.
Alan R. Katritzky, Larisa Serdyuk, Dorin Toader, Xiaojing Wang

J Org Chem· March 1999

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General and Efficient Insertions of Carbons Carrying Aryl and Heteroaryl Groups: Synthesis of alpha-Aryl- and alpha-Heteroaryl-Substituted Ketones.
Alan R. Katritzky, Dorin Toader, Linghong Xie

J Org Chem· October 1996

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