Publications by authors named "Jay Harper"

Claim this Profile
R
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR.
Shenlan Mao, Raghothama Chaerkady, Wen Yu, Gina D'Angelo, Andrew Garcia, Jay Harper

Mol Cancer Ther· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Detecting bliss synergy in in vivo combination studies with a tumor kinetic model.
Wei Zhao, Paolo Vicini, Steven Novick, Judith Anderton, Gareth Davies, Jay Harper

Pharm Stat· November 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers.
Stephen J Gregson, Allison M Barrett, Neki V Patel, Gyoung-Dong Kang, Davide Schiavone, Jay Harper

Eur J Med Chem· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Reactive Antibody Platform for One-Step Production of Antibody-Drug Conjugates through a Diels-Alder Reaction with Maleimide.
Andre H St Amant, Fengying Huang, Jia Lin, Daniel Lemen, Chacko Chakiath, Jay Harper

Bioconjug Chem· September 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potentiation of PBD Dimers by Lipophilicity Manipulation.
Thaїs Cailleau, Lauren R Adams, Neha Arora, Gyoung-Dong Kang, Luke Masterson, Jay Harper

Curr Top Med Chem· July 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Diene-Containing Noncanonical Amino Acid Enables Dual Functionality in Proteins: Rapid Diels-Alder Reaction with Maleimide or Proximity-Based Dimerization.
Andre H St Amant, Fengying Huang, Jia Lin, Keith Rickert, Vaheh Oganesyan, Jay Harper

Angew Chem Int Ed Engl· June 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluation of Pyrrolobenzodiazepine-Loaded Nanoparticles: A Targeted Drug Delivery Approach.
Puneet Tyagi, Sergei Pechenov, Jonathan RiosDoria, Luke Masterson, Niall J Dickinson, Jay Harper

J Pharm Sci· April 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension.
Qing Li, Allison Barrett, Balakumar Vijayakrishnan, Arnaud Tiberghien, Rhiannon Beard, Jay Harper

Bioconjug Chem· April 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Improved Therapeutic Window in -mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition.
Haihong Zhong, Cui Chen, Ravinder Tammali, Shannon Breen, Jing Zhang, Jay Harper

Mol Cancer Ther· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.
John A Hartley, Michael J Flynn, John P Bingham, Simon Corbett, Halla Reinert, Jay Harper

Sci Rep· July 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation.
R James Christie, Arnaud C Tiberghien, Qun Du, Binyam Bezabeh, Ryan Fleming, Jay Harper

Antibodies (Basel)· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
Mary Jane Masson Hinrichs, Pauline M Ryan, Bo Zheng, Shameen Afif-Rider, Xiang Qing Yu, Jay Harper

Clin Cancer Res· October 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Seroconversion rates among health care workers exposed to hepatitis C virus-contaminated body fluids: The University of Pittsburgh 13-year experience.
Francesco M Egro, Chibueze A Nwaiwu, Saundra Smith, Jay D Harper, Alexander M Spiess

Am J Infect Control· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Seroconversion rate among health care workers exposed to HIV-contaminated body fluids: The University of Pittsburgh 13-year experience.
Chibueze A Nwaiwu, Francesco M Egro, Saundra Smith, Jay D Harper, Alexander M Spiess

Am J Infect Control· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.
Jay Harper, Christopher Lloyd, Nazzareno Dimasi, Dorin Toader, Rose Marwood

Mol Cancer Ther· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies.
Jonathan Rios-Doria, Jay Harper, Raymond Rothstein, Leslie Wetzel, Jon Chesebrough

Cancer Res· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Cytotoxicity Relationships of Analogues of N-Desacetoxytubulysin H.
Dorin Toader, Fengjiang Wang, Lakshmaiah Gingipalli, Melissa Vasbinder, Mark Roth, Jay Harper

J Med Chem· December 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics.
Pamela Thompson, Ryan Fleming, Binyam Bezabeh, Fengying Huang, Shenlan Mao, Jay Harper

J Control Release· August 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides.
R James Christie, Ryan Fleming, Binyam Bezabeh, Rob Woods, Shenlan Mao, Jay Harper

J Control Release· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies.
Cecile Rouleau, Diego A Gianolio, Robert Smale, Stephanie D Roth, Roy Krumbholz, Jay Harper

Mol Cancer Ther· September 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Matrilin-1 is an inhibitor of neovascularization.
Matthew J Foradori, Qian Chen, Cecilia A Fernandez, Jay Harper, Xin Li

J Biol Chem· May 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Selecting an optimal antibody for antibody-drug conjugate therapy: internalization and intracellular localization.
Jay Harper, Shenlan Mao, Patrick Strout, Adeela Kamal

Methods Mol Biol· February 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression.
Aram F Hezel, Vikram Deshpande, Stephanie M Zimmerman, Gianmarco Contino, Brinda Alagesan, Jay Harper

Cancer Res· September 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
TGF-β regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence.
Qiang Zhang, Lin Chen, Brian T Helfand, Thomas L Jang, Vidit Sharma, Jay Harper

PLoS One· March 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tumor localization of an anti-TGF-β antibody and its effects on gliomas.
Petra Hülper, Walter Schulz-Schaeffer, Christian Dullin, Peter Hoffmann, Jay Harper

Int J Oncol· January 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis