Publications by authors named "Paul Fielder"

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Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics.
Daniela Bumbaca Yadav, Arthur E Reyes, Priyanka Gupta, Jean-Michel Vernes, Y Gloria Meng, Paul J Fielder

Pharmacol Res Perspect· April 2020

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Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics.
Siddharth Sukumaran, Crystal Zhang, Douglas D Leipold, Ola M Saad, Keyang Xu, Paul Fielder

AAPS J· January 2017

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Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG1 Antibody in Cynomolgus Monkey.
Chee M Ng, Paul J Fielder, Jin Jin, Rong Deng

AAPS J· July 2016

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Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.
Jing Wang, Suhasini Iyer, Paul J Fielder, John D Davis, Rong Deng

Biopharm Drug Dispos· March 2016

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Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.
Victor Yip, Enzo Palma, Devin B Tesar, Eduardo E Mundo, Daniela Bumbaca, Paul J Fielder

MAbs· May 2015

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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.
Yanan Zheng, Devin B Tesar, Lisa Benincosa, Herbert Birnböck, C Andrew Boswell, Paul J Fielder

MAbs· February 2015

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Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues.
C Andrew Boswell, Eduardo E Mundo, Sheila Ulufatu, Daniela Bumbaca, Hendry S Cahaya, Paul J Fielder

Mol Pharm· May 2014

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Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies.
Deborah L Mortensen, Saileta Prabhu, Eric G Stefanich, Saloumeh Kadkhodayan-Fischer, Thomas R Gelzleichter, Paul J Fielder

MAbs· January 2014

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A strategy for risk mitigation of antibodies with fast clearance.
Isidro Hötzel, Frank-Peter Theil, Lisa J Bernstein, Saileta Prabhu, Rong Deng, Paul Fielder

MAbs· January 2014

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Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey.
Chee M Ng, Kelly M Loyet, Suhasini Iyer, Paul J Fielder, Rong Deng

Eur J Pharm Sci· January 2014

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Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies.
C Andrew Boswell, Jan Marik, Michael J Elowson, Noe A Reyes, Sheila Ulufatu, Paul J Fielder

J Med Chem· December 2013

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Vascular physiology and protein disposition in a preclinical model of neurodegeneration.
C Andrew Boswell, Eduardo E Mundo, Bernadette Johnstone, Sheila Ulufatu, Michelle G Schweiger, Paul J Fielder

Mol Pharm· May 2013

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Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics.
Daniela Bumbaca, C Andrew Boswell, Paul J Fielder, Leslie A Khawli

AAPS J· September 2012

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Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations.
C Andrew Boswell, Daniela Bumbaca, Paul J Fielder, Leslie A Khawli

AAPS J· September 2012

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Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.
Rong Deng, Y Gloria Meng, Kwame Hoyte, Jeff Lutman, Yanmei Lu, Paul J Fielder

MAbs· June 2012

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Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice.
Daniela Bumbaca, Hong Xiang, C Andrew Boswell, Ruediger E Port, Shannon L Stainton, Paul J Fielder

Br J Pharmacol· May 2012

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Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model.
Cinthia V Pastuskovas, Eduardo E Mundo, Simon P Williams, Tapan K Nayak, Jason Ho, Paul J Fielder

Mol Cancer Ther· March 2012

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Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis.
Chia-Lin Hsu, Weiyu Lin, Dhaya Seshasayee, Yung-Hsiang Chen, Xiao Ding, Paul Fielder

Science· January 2012

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Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
C Andrew Boswell, Eduardo E Mundo, Crystal Zhang, Daniela Bumbaca, Nicole R Valle, Paul J Fielder

Bioconjug Chem· October 2011

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A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis.
Kasia Owczarczyk, Preeti Lal, Alexander R Abbas, Kristen Wolslegel, Cecile T J Holweg, Paul Fielder

Sci Transl Med· September 2011

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Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?
Rong Deng, Suhasini Iyer, Frank-Peter Theil, Deborah L Mortensen, Paul J Fielder

MAbs· July 2011

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Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow.
C Andrew Boswell, Gregory Z Ferl, Eduardo E Mundo, Daniela Bumbaca, Michelle G Schweiger, Paul J Fielder

PLoS One· March 2011

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Effect of immune complex formation on the distribution of a novel antibody to the ovarian tumor antigen CA125.
Cinthia V Pastuskovas, William Mallet, Suzanna Clark, Margaret Kenrick, Mohammed Majidy, Paul Fielder

Drug Metab Dispos· December 2010

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Effects of charge on antibody tissue distribution and pharmacokinetics.
C Andrew Boswell, Devin B Tesar, Kiran Mukhyala, Frank-Peter Theil, Paul J Fielder

Bioconjug Chem· December 2010

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Development and evaluation of a novel method for preclinical measurement of tissue vascular volume.
C Andrew Boswell, Gregory Z Ferl, Eduardo E Mundo, Michelle G Schweiger, Jan Marik, Paul J Fielder

Mol Pharm· October 2010

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