Publications by authors named "Paul Modrich"

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Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.
Lyudmila Y Kadyrova, Vaibhavi Gujar, Vickers Burdett, Paul L Modrich, Farid A Kadyrov

Proc Natl Acad Sci U S A· February 2020

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The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease.
Shanen M Sherrer, Elisabeth Penland, Paul Modrich

Proc Natl Acad Sci U S A· July 2018

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Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair.
Jochen Genschel, Lyudmila Y Kadyrova, Ravi R Iyer, Basanta K Dahal, Farid A Kadyrov, Paul Modrich

Proc Natl Acad Sci U S A· May 2017

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Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).
Paul Modrich

Angew Chem Int Ed Engl· July 2016

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The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.
Yu-Tsung Shane Chen, Jianhong Wu, Paul Modrich, Tao-Shih Hsieh

J Biol Chem· June 2016

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The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage.
Tomas Lindahl, Paul Modrich, Aziz Sancar

J Assoc Genet Technol· May 2016

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MutL traps MutS at a DNA mismatch.
Ruoyi Qiu, Miho Sakato, Elizabeth J Sacho, Hunter Wilkins, Xingdong Zhang, Paul Modrich

Proc Natl Acad Sci U S A· September 2015

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Hydrolytic function of Exo1 in mammalian mismatch repair.
Hongbing Shao, Celia Baitinger, Erik J Soderblom, Vickers Burdett, Paul Modrich

Nucleic Acids Res· June 2014

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Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.
Laura A Lindsey-Boltz, Michael G Kemp, Joyce T Reardon, Vanessa DeRocco, Ravi R Iyer, Paul Modrich

J Biol Chem· February 2014

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Christian Raetz: scientist and friend extraordinaire.
William Dowhan, Hiroshi Nikaido, JoAnne Stubbe, John W Kozarich, William T Wickner, Paul Modrich

Annu Rev Biochem· November 2013

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Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation.
Anna Pluciennik, Vickers Burdett, Celia Baitinger, Ravi R Iyer, Kevin Shi, Paul Modrich

Proc Natl Acad Sci U S A· July 2013

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PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro.
Yiyong Liu, Farid A Kadyrov, Paul Modrich

DNA Repair (Amst)· November 2011

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Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.
Quincy Tseng, Jillian Orans, Michael A Hast, Ravi R Iyer, Anita Changela, Paul L Modrich

Acta Crystallogr Sect F Struct Biol Cryst Commun· August 2011

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Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Jillian Orans, Elizabeth A McSweeney, Ravi R Iyer, Michael A Hast, Homme W Hellinga, Paul Modrich

Cell· April 2011

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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Amitabh V Nimonkar, Jochen Genschel, Eri Kinoshita, Piotr Polaczek, Judith L Campbell, Paul Modrich

Genes Dev· February 2011

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PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair.
Anna Pluciennik, Leonid Dzantiev, Ravi R Iyer, Nicoleta Constantin, Farid A Kadyrov, Paul Modrich

Proc Natl Acad Sci U S A· September 2010

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Structure of the endonuclease domain of MutL: unlicensed to cut.
Monica C Pillon, Jessica J Lorenowicz, Michael Uckelmann, Andrew D Klocko, Ryan R Mitchell, Paul Modrich

Mol Cell· July 2010

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PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.
Johanna M M van Oers, Sergio Roa, Uwe Werling, Yiyong Liu, Jochen Genschel, Paul Modrich

Proc Natl Acad Sci U S A· July 2010

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MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.
Ravi R Iyer, Anna Pluciennik, Jochen Genschel, Miaw-Sheue Tsai, Lorena S Beese, Paul Modrich

J Biol Chem· April 2010

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Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.
Yiyong Liu, Yanan Fang, Hongbing Shao, Laura Lindsey-Boltz, Aziz Sancar, Paul Modrich

J Biol Chem· February 2010

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Involvement of the beta clamp in methyl-directed mismatch repair in vitro.
Anna Pluciennik, Vickers Burdett, Olga Lukianova, Mike O'Donnell, Paul Modrich

J Biol Chem· November 2009

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Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair.
Jochen Genschel, Paul Modrich

J Biol Chem· August 2009

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Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.
Junhua Zhao, Aklank Jain, Ravi R Iyer, Paul L Modrich, Karen M Vasquez

Nucleic Acids Res· July 2009

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A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.
Farid A Kadyrov, Jochen Genschel, Yanan Fang, Elisabeth Penland, Winfried Edelmann, Paul Modrich

Proc Natl Acad Sci U S A· May 2009

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Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.
Amitabh V Nimonkar, A Zeynep Ozsoy, Jochen Genschel, Paul Modrich, Stephen C Kowalczykowski

Proc Natl Acad Sci U S A· November 2008

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