Publications by authors named "Paul Nicklin"

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Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.
Gebhard Thoma, Wolfgang Miltz, Rudolf Waelchli, David Orain, Carsten Spanka, Paul Nicklin

J Med Chem· February 2025

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An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral.
Miao Mei, Maria Antonietta Impagnatiello, Jun Jiao, Ulrich Reiser, Ulrike Tontsch-Grunt, Paul Nicklin

Protein Cell· January 2024

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Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis.
Yang Yang, Daniela M Santos, Lorena Pantano, Rachel Knipe, Elizabeth Abe, Paul Nicklin

Am J Respir Cell Mol Biol· July 2022

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opnMe.com: a digital initiative for sharing tools with the biomedical research community.
Andreas Gollner, Markus Köster, Paul Nicklin, Thomas Trieselmann, Elliott Klein

Nat Rev Drug Discov· July 2022

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Targeting Cathepsin C in PR3-ANCA Vasculitis.
Uwe Jerke, Claudia Eulenberg-Gustavus, Anthony Rousselle, Paul Nicklin, Stefan Kreideweiss

J Am Soc Nephrol· May 2022

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New Targets for Antiviral Therapy: Inhibitory Receptors and Immune Checkpoints on Myeloid Cells.
Yanni Liu, Paul Nicklin, Yuan He

Viruses· May 2022

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Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
Benjamin R Bellenie, Edward Hall, Ian Bruce, Matthew Spendiff, Andrew Culshaw, Paul Nicklin

J Med Chem· August 2021

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Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction.
Cristina Escrevente, Ana S Falcão, Michael J Hall, Mafalda Lopes-da-Silva, Pedro Antas, Paul Nicklin

Invest Ophthalmol Vis Sci· July 2021

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Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis.
Daniela M Santos, Lorena Pantano, Gina Pronzati, Paula Grasberger, Clemens K Probst, Paul Nicklin

Am J Respir Cell Mol Biol· April 2020

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Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slices.
Emilia Bigaeva, Emilia Gore, Eric Simon, Matthias Zwick, Anouk Oldenburger, Paul Nicklin

Arch Toxicol· December 2019

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Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis.
Eva Schruf, Victoria Schroeder, Christian A Kuttruff, Sabine Weigle, Martin Krell, Paul Nicklin

Respir Res· May 2019

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FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target.
Marc Kästle, Barbara Kistler, Thorsten Lamla, Tom Bretschneider, David Lamb, Paul Nicklin

Eur J Immunol· November 2018

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Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
Christian A Kuttruff, Marco Ferrara, Tom Bretschneider, Stefan Hoerer, Sandra Handschuh, Paul Nicklin

ACS Med Chem Lett· December 2017

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Ultrafast and Predictive Mass Spectrometry-Based Autotaxin Assays for Label-Free Potency Screening.
Tom Bretschneider, Andreas Harald Luippold, Helmut Romig, Daniel Bischoff, Klaus Klinder, Paul Nicklin

SLAS Discov· April 2017

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Design and synthesis of a library of chemokine antagonists.
Gurdip Bhalay, Birgit Albrecht, Mohammed Akhlaq, Urs Baettig, David Beer, Paul Nicklin

Bioorg Med Chem Lett· November 2011

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Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.
Elaine Soon, Alan M Holmes, Carmen M Treacy, Natalie J Doughty, Laura Southgate, Paul Nicklin

Circulation· August 2010

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Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
Rowan A Stringer, Claire Strain-Damerell, Paul Nicklin, J Brian Houston

Drug Metab Dispos· May 2009

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Bidirectional transport of amino acids regulates mTOR and autophagy.
Paul Nicklin, Philip Bergman, Bailin Zhang, Ellen Triantafellow, Henry Wang

Cell· February 2009

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Potent and selective xanthine-based inhibitors of phosphodiesterase 5.
Nichola J Arnold, Ruth Arnold, David Beer, Gurdip Bhalay, Stephen P Collingwood, Paul A Nicklin

Bioorg Med Chem Lett· April 2007

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Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats.
Paul R Eynott, Michael Salmon, Tung-Jung Huang, Timothy Oates, Paul L Nicklin

Immunology· July 2003

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8-Aryl xanthines potent inhibitors of phosphodiesterase 5.
Ruth Arnold, David Beer, Gurdip Bhalay, Urs Baettig, Stephen P Collingwood, Paul Nicklin

Bioorg Med Chem Lett· September 2002

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Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats.
Tung Jung Huang, Paul Eynott, Michael Salmon, Paul L Nicklin, K Fan Chung

Eur J Pharmacol· February 2002

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