Publications by authors named "Carsten Spanka"

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Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.
Gebhard Thoma, Wolfgang Miltz, Rudolf Waelchli, David Orain, Carsten Spanka

J Med Chem· February 2025

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Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
Gebhard Thoma, Christian Markert, Rainer Lueoend, Wolfgang Miltz, Carsten Spanka

J Med Chem· December 2023

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Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin.
Marion Rusch, Arnaud Thevenon, Dominic Hoepfner, Thomas Aust, Christian Studer, Carsten Spanka

Chembiochem· March 2019

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A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets.
Ye-Jin Hwang, Connor W Coley, Milad Abolhasani, Andreas L Marzinzik, Guido Koch, Carsten Spanka

Chem Commun (Camb)· June 2017

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The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.
David W Porter, Michelle Bradley, Zarin Brown, Riccardo Canova, Steven Charlton, Carsten Spanka

Bioorg Med Chem Lett· January 2014

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Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
Vito Guagnano, Pascal Furet, Carsten Spanka, Vincent Bordas, Mickaël Le Douget

J Med Chem· October 2011

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Oxysterols direct immune cell migration via EBI2.
Sébastien Hannedouche, Juan Zhang, Tangsheng Yi, Weijun Shen, Deborah Nguyen, Carsten Spanka

Nature· July 2011

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Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.
Carsten Spanka, Ralf Glatthar, Sandrine Desrayaud, Markus Fendt, David Orain

Bioorg Med Chem Lett· January 2010

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N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
Zheng Yin, Yen-Liang Chen, Ravinder Reddy Kondreddi, Wai Ling Chan, Gang Wang, Carsten Spanka

J Med Chem· December 2009

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Soluble polymer-supported methods for combinatorial and organic synthesis.
Paul Wentworth, Carsten Spanka

Methods Mol Biol· April 2003

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Application of microgels as polymer supports for organic synthesis: preparation of a small phthalide library, a scavenger, and a borohydride reagent.
Osamu Shimomura, Bruce Clapham, Carsten Spanka, Suresh Mahajan, Kim D Janda

J Comb Chem· October 2002

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A tunable hydrogel for encapsulation and controlled release of bioactive proteins.
Mercedes Delgado, Carsten Spanka, Lisa D Kerwin, Paul Wentworth, Kim D Janda

Biomacromolecules· July 2002

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Developing soluble polymers for high-throughput synthetic chemistry.
Carsten Spanka, Paul Wentworth, Kim D Janda

Comb Chem High Throughput Screen· May 2002

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Preparation of new microgel polymers and their application as supports in organic synthesis.
Carsten Spanka, Bruce Clapham, Kim D Janda

J Org Chem· May 2002

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A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity.
Mercedes Delgado, Kyung Joo Lee, Lawrence Altobell, Carsten Spanka, Paul Wentworth

J Am Chem Soc· May 2002

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