Publications by authors named "Steven Charlton"

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Development of a BRET based chloride biosensor for high throughput screening of KCC2 modulators.
Charles S Lay, Elvira Diamantopoulou, Katharina L Dürr, Idlir Liko, Steven J Charlton

SLAS Discov· September 2025

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Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting β-adrenoceptor agonist, indacaterol, in human airway epithelial cells.
Varuna Jayasinghe, Radhika Joshi, Taruna Joshi, Tamkeen U Paracha, Cora Kooi, Steven J Charlton

J Pharmacol Exp Ther· June 2025

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Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D Receptor.
Herman D Lim, Damian Bartuzi, Alastair C Keen, Caroline Rauffenbart, Jacqueline Glenn, Steven J Charlton

ACS Chem Neurosci· June 2025

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Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2.
Bianca Maria Casella, James P Farmer, Desislava N Nesheva, Huw E L Williams, Steven J Charlton

J Med Chem· September 2023

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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor.
Hsin-Yung Yen, Idlir Liko, Wanling Song, Parth Kapoor, Fernando Almeida, Steven J Charlton

Nat Chem· December 2022

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Exploring the kinetic selectivity of drugs targeting the β -adrenoceptor.
David A Sykes, Mireia Jiménez-Rosés, John Reilly, Robin A Fairhurst, Steven J Charlton

Pharmacol Res Perspect· August 2022

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Interaction With the Lipid Membrane Influences Fentanyl Pharmacology.
Katy J Sutcliffe, Robin A Corey, Norah Alhosan, Damiana Cavallo, Sam Groom, Steven J Charlton

Adv Drug Alcohol Res· March 2022

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Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus.
Maxine J Roberts, Lauren T May, Alastair C Keen, Bonan Liu, Terrance Lam, Steven J Charlton

Front Pharmacol· April 2021

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Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D Receptor.
Tim J Fyfe, Barrie Kellam, David A Sykes, Ben Capuano, Peter J Scammells, Steven J Charlton

J Med Chem· November 2019

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Investigating the Influence of Tracer Kinetics on Competition-Kinetic Association Binding Assays: Identifying the Optimal Conditions for Assessing the Kinetics of Low-Affinity Compounds.
David A Sykes, Palash Jain, Steven J Charlton

Mol Pharmacol· September 2019

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Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived -Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies.
Magdalena Koziczak-Holbro, Dean F Rigel, Bérengère Dumotier, David A Sykes, Jeffrey Tsao, Steven J Charlton

J Pharmacol Exp Ther· May 2019

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Single Step Determination of Unlabeled Compound Kinetics Using a Competition Association Binding Method Employing Time-Resolved FRET.
David A Sykes, Steven J Charlton

Methods Mol Biol· March 2019

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Airway remodeling disease: primary human structural cells and phenotypic and pathway assays to identify targets with potential to prevent or reverse remodeling.
Elizabeth M Rosethorne, Steven J Charlton

J Exp Pharmacol· November 2018

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Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations.
Srgjan Civciristov, Andrew M Ellisdon, Ryan Suderman, Cindy K Pon, Bronwyn A Evans, Steven J Charlton

Sci Signal· October 2018

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Reply to 'Antipsychotics with similar association kinetics at dopamine D receptors differ in extrapyramidal side-effects'.
David A Sykes, J Robert Lane, Monika Szabo, Ben Capuano, Jonathan A Javitch, Steven J Charlton

Nat Commun· September 2018

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Biased Agonism in Drug Discovery-Is It Too Soon to Choose a Path?
Martin C Michel, Steven J Charlton

Mol Pharmacol· April 2018

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The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response.
Maxine J Roberts, Rebecca E Broome, Toby C Kent, Steven J Charlton, Elizabeth M Rosethorne

Respir Res· April 2018

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Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes.
Karolina Gherbi, Stephen J Briddon, Steven J Charlton

Sci Rep· February 2018

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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D receptors.
David A Sykes, Holly Moore, Lisa Stott, Nicholas Holliday, Jonathan A Javitch, Steven J Charlton

Nat Commun· October 2017

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Correction to "Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP Receptor Antagonist for Treatment of Asthma".
David A Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Steven J Charlton

ACS Med Chem Lett· September 2017

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Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP Receptor Antagonist for Treatment of Asthma.
David A Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Steven J Charlton

ACS Med Chem Lett· May 2017

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Uncoupling the Structure-Activity Relationships of β2 Adrenergic Receptor Ligands from Membrane Binding.
Callum J Dickson, Viktor Hornak, Camilo Velez-Vega, Daniel J J McKay, John Reilly, Steven J Charlton

J Med Chem· June 2016

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Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.
David A Sykes, Michelle E Bradley, Darren M Riddy, Elizabeth Willard, John Reilly, Steven J Charlton

Mol Pharmacol· May 2016

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Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor.
Elizabeth M Rosethorne, Michelle E Bradley, Karolina Gherbi, David A Sykes, Afrah Sattikar, Steven J Charlton

Mol Pharmacol· April 2016

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The role of kinetic context in apparent biased agonism at GPCRs.
Carmen Klein Herenbrink, David A Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Steven J Charlton

Nat Commun· February 2016

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