Publications by authors named "Paul Stocks"

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Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Paul M O' Neill, Paul A Stocks, Sunil Sabbani, Natalie L Roberts, Richard K Amewu

Bioorg Med Chem· July 2018

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Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.
W David Hong, Peter D Gibbons, Suet C Leung, Richard Amewu, Paul A Stocks

J Med Chem· May 2017

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Glutathione transport: a new role for PfCRT in chloroquine resistance.
Eva-Maria Patzewitz, J Enrique Salcedo-Sora, Eleanor H Wong, Sonal Sethia, Paul A Stocks

Antioxid Redox Signal· September 2013

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Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
Louise La Pensée, Sunil Sabbani, Raman Sharma, Inder Bhamra, Emma Shore, Paul A Stocks

ChemMedChem· May 2013

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HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.
Cindy Vallières, Nicholas Fisher, Thomas Antoine, Mohammed Al-Helal, Paul Stocks

Antimicrob Agents Chemother· July 2012

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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Giancarlo A Biagini, Nicholas Fisher, Alison E Shone, Murad A Mubaraki, Abhishek Srivastava, Paul A Stocks

Proc Natl Acad Sci U S A· May 2012

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Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.
Raman Sharma, Alexandre S Lawrenson, Nicholas E Fisher, Ashley J Warman, Alison E Shone, Paul Stocks

J Med Chem· April 2012

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Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Chandrakala Pidathala, Richard Amewu, Bénédicte Pacorel, Gemma L Nixon, Peter Gibbons, Paul A Stocks

J Med Chem· March 2012

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Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Suet C Leung, Peter Gibbons, Richard Amewu, Gemma L Nixon, Chandrakala Pidathala, Paul A Stocks

J Med Chem· March 2012

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The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters.
J Enrique Salcedo-Sora, Edwin Ochong, Susan Beveridge, David Johnson, Alexis Nzila, Paul A Stocks

J Biol Chem· December 2011

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Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.
James Chadwick, Richard K Amewu, Francesc Marti, Fatima Bousejra-El Garah, Raman Sharma, Paul A Stocks

ChemMedChem· August 2011

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Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Peter Gibbons, Edite Verissimo, Nuna C Araujo, Victoria Barton, Gemma L Nixon, Paul A Stocks

J Med Chem· November 2010

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Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Richard Amewu, Peter Gibbons, Amira Mukhtar, Andrew V Stachulski, Stephen A Ward, Paul A Stocks

Org Biomol Chem· May 2010

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Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.
James Chadwick, Michael Jones, Amy E Mercer, Paul A Stocks, Stephen A Ward

Bioorg Med Chem· April 2010

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Antitumour and antimalarial activity of artemisinin-acridine hybrids.
Michael Jones, Amy E Mercer, Paul A Stocks, Louise J I La Pensée, Rick Cosstick

Bioorg Med Chem Lett· April 2009

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Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.
Nuna C P Araújo, Victoria Barton, Michael Jones, Paul A Stocks, Stephen A Ward

Bioorg Med Chem Lett· April 2009

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Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
Paul M O'Neill, Alison E Shone, Deborah Stanford, Gemma Nixon, Eghbaleh Asadollahy, Paul A Stocks

J Med Chem· April 2009

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Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Paul M O'Neill, B Kevin Park, Alison E Shone, James L Maggs, Phillip Roberts, Paul A Stocks

J Med Chem· March 2009

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Piperidine dispiro-1,2,4-trioxane analogues.
Sunil Sabbani, Paul A Stocks, Gemma L Ellis, Jill Davies, Erik Hedenstrom

Bioorg Med Chem Lett· November 2008

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Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.
Giancarlo A Biagini, Nicholas Fisher, Neil Berry, Paul A Stocks, Brigitte Meunier

Mol Pharmacol· May 2008

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Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Gemma L Ellis, Richard Amewu, Sunil Sabbani, Paul A Stocks, Alison Shone

J Med Chem· April 2008

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Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Paul A Stocks, Patrick G Bray, Victoria E Barton, Mohammed Al-Helal, Michael Jones

Angew Chem Int Ed Engl· October 2007

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PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Patrick G Bray, Mathirut Mungthin, Ian M Hastings, Giancarlo A Biagini, Dauda K Saidu, Paul A Stocks

Mol Microbiol· October 2006

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Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.
Paul M O'Neill, Edite Verissimo, Stephen A Ward, Jill Davies, Edward E Korshin, Paul A Stocks

Bioorg Med Chem Lett· June 2006

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Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.
Paul M O'Neill, Amira Mukhtar, Stephen A Ward, Jamie F Bickley, Jill Davies, Paul A Stocks

Org Lett· September 2004

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