Publications by authors named "Peter Dosa"

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Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin.
Sean Miletic, Simoun Icho, Zhijie Li, John Tam, Elizabeth C Rose, Peter I Dosa

Nat Microbiol· December 2025

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SARS-CoV-2 M inhibitor identification using a cellular gain-of-signal assay for high-throughput screening.
Renee Delgado, Jyoti Vishwakarma, Seyed Arad Moghadasi, Yuka Otsuka, Justin Shumate, Peter I Dosa

SLAS Discov· September 2024

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Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats.
James G Pfaus, Radu A Antonie, Peter I Dosa, Suck Won Kim

Psychopharmacology (Berl)· April 2024

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Mitochondria-targeted metformin (mitomet) inhibits lung cancer in cellular models and in mice by enhancing the generation of reactive oxygen species.
Mohammad Shameem, Alireza Jian Bagherpoor, Ali Nakhi, Peter Dosa, Gunda Georg

Mol Carcinog· November 2023

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K Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine-Induced Hypersensitivity, and Precipitated Withdrawal in Mice.
Alexis Doucette, Kayla Johnson, Shelby Hulke, Sunna Mujteba, Elena Miller, Peter I Dosa

J Pharmacol Exp Ther· October 2023

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Preclinical Pharmacokinetic Profile of Topical Ophthalmic and Intravenous Delivery of QLS-101, a Novel ATP-Sensitive Potassium Channel Opening Ocular Hypotensive Agent.
Uttio Roy Chowdhury, Cynthia L Pervan-Steel, Ryan Sheeler, Hemchand K Sookdeo, Brian Rogers, Peter I Dosa

J Ocul Pharmacol Ther· June 2023

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Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation.
Adam Joules, Tessa Burrows, Peter Dosa, Allison Hubel

J Mol Liq· February 2023

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Ocular Hypotensive Properties and Biochemical Profile of QLS-101, a Novel ATP-Sensitive Potassium (KATP) Channel Opening Prodrug.
Cynthia L Pervan-Steel, Uttio Roy Chowdhury, Hemchand K Sookdeo, Ralph A Casale, Peter I Dosa

Invest Ophthalmol Vis Sci· April 2022

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Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models.
Uttio Roy Chowdhury, J Cameron Millar, Bradley H Holman, Kjersten J Anderson, Peter I Dosa

Invest Ophthalmol Vis Sci· February 2022

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Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates.
Uttio Roy Chowdhury, Rachel A Kudgus, Bradley H Holman, Tommy A Rinkoski, Cheryl R Hann, Peter I Dosa

J Ocul Pharmacol Ther· June 2021

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Structural modifications that increase gut restriction of bile acid derivatives.
Ali Nakhi, Henry L Wong, Melissa Weldy, Alexander Khoruts, Michael J Sadowsky, Peter I Dosa

RSC Med Chem· March 2021

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Convenient Protocol for Production and Purification of Spores for Germination Studies.
Melissa Weldy, Clayton Evert, Peter I Dosa, Alexander Khoruts, Michael J Sadowsky

STAR Protoc· September 2020

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Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits.
Uttio Roy Chowdhury, Rachel A Kudgus, Tommy A Rinkoski, Bradley H Holman, Cindy K Bahler, Peter I Dosa

PLoS One· August 2020

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Differential Evolution for the Optimization of DMSO-Free Cryoprotectants: Influence of Control Parameters.
Chia-Hsing Pi, Peter I Dosa, Allison Hubel

J Biomech Eng· July 2020

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Understanding the freezing responses of T cells and other subsets of human peripheral blood mononuclear cells using DSMO-free cryoprotectants.
Chia-Hsing Pi, Kathlyn Hornberger, Peter Dosa, Allison Hubel

Cytotherapy· May 2020

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The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel.
Sang-Kyu Park, Gihan S Gunaratne, Evgeny G Chulkov, Francie Moehring, Paul McCusker, Peter I Dosa

J Biol Chem· December 2019

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7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
Ali Nakhi, Connor M McDermott, Kristen L Stoltz, Kristen John, Jon E Hawkinson, Peter I Dosa

J Med Chem· July 2019

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Characterizing modes of action and interaction for multicomponent osmolyte solutions on Jurkat cells.
Chia-Hsing Pi, Guanglin Yu, Peter I Dosa, Allison Hubel

Biotechnol Bioeng· March 2019

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Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers.
Gihan S Gunaratne, Nawal A Yahya, Peter I Dosa, Jonathan S Marchant

PLoS Negl Trop Dis· April 2018

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The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand.
John D Chan, Pauline M Cupit, Gihan S Gunaratne, John D McCorvy, Yang Yang, Peter I Dosa

Nat Commun· December 2017

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Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents.
Uttio Roy Chowdhury, Tommy A Rinkoski, Cindy K Bahler, J Cameron Millar, Jacques A Bertrand, Peter I Dosa

Invest Ophthalmol Vis Sci· November 2017

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Improved Post-Thaw Function and Epigenetic Changes in Mesenchymal Stromal Cells Cryopreserved Using Multicomponent Osmolyte Solutions.
Kathryn Pollock, Rebekah M Samsonraj, Amel Dudakovic, Roman Thaler, Aron Stumbras, Peter I Dosa

Stem Cells Dev· June 2017

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Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination.
Kristen L Stoltz, Raymond Erickson, Christopher Staley, Alexa R Weingarden, Erin Romens, Peter I Dosa

J Med Chem· April 2017

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Combinations of Osmolytes, Including Monosaccharides, Disaccharides, and Sugar Alcohols Act in Concert During Cryopreservation to Improve Mesenchymal Stromal Cell Survival.
Kathryn Pollock, Guanglin Yu, Ralph Moller-Trane, Marissa Koran, Peter I Dosa

Tissue Eng Part C Methods· November 2016

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Analogs of the ATP-Sensitive Potassium (KATP) Channel Opener Cromakalim with in Vivo Ocular Hypotensive Activity.
Uttio Roy Chowdhury, Kimberly B Viker, Kristen L Stoltz, Bradley H Holman, Michael P Fautsch, Peter I Dosa

J Med Chem· July 2016

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