Publications by authors named "Peter Ruminski"

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A simplified G-CSF-free procedure allows for in vivo HSC gene therapy of sickle cell disease in a mouse model.
Chang Li, Anna K Anderson, Peter Ruminski, Michael Rettig, Darja Karpova

Blood Adv· August 2024

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Development of VLA4 and CXCR4 Antagonists for the Mobilization of Hematopoietic Stem and Progenitor Cells.
Peter G Ruminski, Michael P Rettig, John F DiPersio

Biomolecules· August 2024

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Novel JAK Inhibitors to Reduce Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation in a Preclinical Mouse Model.
Sena Kim, Peter Ruminski, Megh Singh, Karl Staser, Kidist Ashami

Molecules· April 2024

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Targeting CXCR4, VLA-4, and CXCR2 for hematopoietic stem cell mobilization.
Daniel Cancilla, Michael P Rettig, Darja Karpova, Haresh Thakellapalli, Megh Singh, Peter G Ruminski

Blood Adv· March 2024

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MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors.
Dana C Borcherding, Neha V Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Peter Ruminski

Clin Cancer Res· April 2023

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Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β.
Nina Noskovicova, Ronen Schuster, Sander van Putten, Maya Ezzo, Anne Koehler, Peter Ruminski

Nat Biomed Eng· December 2021

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Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation.
Stephen P Persaud, Julie K Ritchey, Sena Kim, Sora Lim, Peter G Ruminski

J Clin Invest· December 2021

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Selective targeting of α4β1 integrin attenuates murine graft versus host disease.
Bader Alahmari, Matthew L Cooper, Kiran Vij, Julie Ritchey, Peter Ruminski

Leukemia· November 2020

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Insights into the role of the JAK/STAT signaling pathway in graft--host disease.
Ramzi Abboud, Jaebok Choi, Peter Ruminski, Mark A Schroeder, Sena Kim

Ther Adv Hematol· June 2020

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Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells.
Darja Karpova, Michael P Rettig, Julie Ritchey, Daniel Cancilla, Stephanie Christ, Peter G Ruminski

J Clin Invest· May 2019

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Cell Attachment and Spreading on Carbon Nanotubes Is Facilitated by Integrin Binding.
Mozhdeh Imaninezhad, Joseph Schober, David Griggs, Peter Ruminski, Irma Kuljanishvili

Front Bioeng Biotechnol· September 2018

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Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis.
Malkeet Kumar, Kawaljit Singh, Andile H Ngwane, Fahreta Hamzabegovic, Getahun Abate, Peter Ruminski

Bioorg Med Chem· February 2018

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Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis.
Malkeet Kumar, Kawaljit Singh, Krupa Naran, Fahreta Hamzabegovic, Daniel F Hoft, Peter Ruminski

ACS Infect Dis· October 2016

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Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.
Barbara Ulmasov, Brent A Neuschwander-Tetri, Jinping Lai, Vladimir Monastyrskiy, Trisha Bhat, Peter G Ruminski

Cell Mol Gastroenterol Hepatol· July 2016

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Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.
David W Griggs, Michael J Prinsen, Jonathan Oliva, Mary A Campbell, Stacy D Arnett, Peter G Ruminski

J Pharmacol Exp Ther· May 2016

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Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
Peter G Ruminski, Mark Massa, Joseph Strohbach, Cathleen E Hanau, Michelle Schmidt

J Med Chem· January 2016

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Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents.
Marvin J Meyers, Elizabeth J Anderson, Sarah A McNitt, Thomas M Krenning, Megh Singh, Peter G Ruminski

Bioorg Med Chem· August 2015

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Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c.
Kawaljit Singh, Malkeet Kumar, Elumalai Pavadai, Krupa Naran, Digby F Warner, Peter G Ruminski

Bioorg Med Chem Lett· July 2014

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Evaluation of aminohydantoins as a novel class of antimalarial agents.
Marvin J Meyers, Micky D Tortorella, Jing Xu, Limei Qin, Zhengxiang He, Peter G Ruminski

ACS Med Chem Lett· January 2014

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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Neil C Henderson, Thomas D Arnold, Yoshio Katamura, Marilyn M Giacomini, Juan D Rodriguez, Peter G Ruminski

Nat Med· December 2013

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Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.
Mahesh Yadav, Cedric Louvet, Dan Davini, James M Gardner, Marc Martinez-Llordella, Peter Ruminski

J Exp Med· September 2012

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From bench to clinic: bridging the translational gap in neglected disease drug development.
Peter G Ruminski

Future Med Chem· August 2011

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Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.
Steven Settle, Lillian Vickery, Olga Nemirovskiy, Tom Vidmar, Alison Bendele, Peter Ruminski

Arthritis Rheum· October 2010

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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Mark E Schnute, Patrick M O'Brien, Joe Nahra, Mark Morris, W Howard Roark, Peter G Ruminski

Bioorg Med Chem Lett· January 2010

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R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors.
Srinivasan R Nagarajan, Balekudru Devadas, James W Malecha, Hwang-Fun Lu, Peter G Ruminski

Bioorg Med Chem· June 2007

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