Publications by authors named "Peter T Cheng"

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Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry.
Michael D Mandler, Andrew P Degnan, Shasha Zhang, Darpandeep Aulakh, Ketleine Georges, Peter T Cheng

Org Lett· January 2022

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Nickel-Catalyzed 1,2-Carboamination of Alkenyl Alcohols.
Taeho Kang, Nana Kim, Peter T Cheng, Hao Zhang, Klement Foo

J Am Chem Soc· September 2021

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A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen.
Zhen Li, Zhen Wang, Nikita Chekshin, Shaoqun Qian, Jennifer X Qiao, Peter T Cheng

Science· June 2021

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Selective C-H Halogenation with a Highly Fluorinated Manganese Porphyrin.
Gang Li, Andrew K Dilger, Peter T Cheng, William R Ewing, John T Groves

Angew Chem Int Ed Engl· January 2018

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Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
Yan Shi, Jun Li, Lawrence J Kennedy, Shiwei Tao, Andrés S Hernández, Peter T W Cheng

ACS Med Chem Lett· June 2016

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Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.
Jian He, Heng Jiang, Ryosuke Takise, Ru-Yi Zhu, Gang Chen, Peter T W Cheng

Angew Chem Int Ed Engl· January 2016

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Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.
Mark Tirmenstein, Joseph Horvath, Michael Graziano, Raja Mangipudy, Thomas Dorr, Peter T W Cheng

Toxicol Pathol· August 2015

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Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Hao Zhang, Charles Z Ding, Zhi Lai, Sean S Chen, Pratik Devasthale, Fucheng Qu, Peter T W Cheng

Bioorg Med Chem Lett· March 2015

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Metabolism and disposition of 14C-labeled peliglitazar in humans.
Lifei Wang, Carey Munsick, Sean Chen, Samuel Bonacorsi, Peter T Cheng

Drug Metab Dispos· February 2011

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Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment.
Donglu Zhang, Nirmala Raghavan, Lifei Wang, Yongjun Xue, Mary Obermeier, Peter T Cheng

Drug Metab Dispos· January 2011

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Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.
Xiang-Yang Ye, Stephanie Chen, Hao Zhang, Kenneth T Locke, Kevin O'Malley, Peter T W Cheng

Bioorg Med Chem Lett· May 2010

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Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
Jun Li, Lawrence J Kennedy, Yan Shi, Shiwei Tao, Xiang-Yang Ye, Peter T W Cheng

J Med Chem· April 2010

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Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma-patient- and treatment-related risk factors.
Anne W M Lee, W T Ng, W M Hung, C W Choi, Raymond Tung, Peter T C Cheng

Int J Radiat Oncol Biol Phys· March 2009

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Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Hao Zhang, Denis E Ryono, Pratik Devasthale, Wei Wang, Kevin O'Malley, Peter T W Cheng

Bioorg Med Chem Lett· March 2009

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Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.
Ranjan Mukherjee, Kenneth T Locke, Bowman Miao, Daniel Meyers, Hossain Monshizadegan, Peter T Cheng

J Pharmacol Exp Ther· December 2008

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Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
Xiang-Yang Ye, Yi-Xin Li, Dennis Farrelly, Neil Flynn, Liqun Gu, Peter T W Cheng

Bioorg Med Chem Lett· June 2008

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Potential improvement of tumor control probability by induction chemotherapy for advanced nasopharyngeal carcinoma.
Anne W M Lee, Kam Ying Lau, Wai Man Hung, Wai Tong Ng, Michael C H Lee, Peter T C Cheng

Radiother Oncol· May 2008

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Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
Wei Wang, Pratik Devasthale, Dennis Farrelly, Liqun Gu, Thomas Harrity, Peter T W Cheng

Bioorg Med Chem Lett· March 2008

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Mass defect filtering on high resolution LC/MS data as a methodology for detecting metabolites with unpredictable structures: identification of oxazole-ring opened metabolites of muraglitazar.
Donglu Zhang, Peter T Cheng, Haiying Zhang

Drug Metab Lett· December 2007

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Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.
Andrés S Hernández, Peter T W Cheng, Christa M Musial, Stephen G Swartz, Rocco J George

Bioorg Med Chem Lett· November 2007

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Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
Jun Li, Stephanie Y Chen, James J Li, Haixia Wang, Andres S Hernandez, Fucheng Qu, Peter T W Cheng

J Med Chem· November 2007

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The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.
Effie Tozzo, Randolph Ponticiello, JoAnn Swartz, Dennis Farrelly, Rachel Zebo, Peter T Cheng

J Pharmacol Exp Ther· April 2007

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Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.
Pratik V Devasthale, Sean Chen, Yoon Jeon, Fucheng Qu, Denis E Ryono, Lin Cheng, Peter T W Cheng

Bioorg Med Chem Lett· April 2007

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A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.
Ramakrishna Seethala, Rajasree Golla, Zhengping Ma, Hao Zhang, Kevin O'Malley, Lin Cheng, Peter T W Cheng

Anal Biochem· April 2007

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Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.
Donglu Zhang, Lifei Wang, Nirmala Raghavan, Haiying Zhang, Wenying Li, Peter T Cheng

Drug Metab Dispos· January 2007

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