Publications by authors named "Mark Tirmenstein"

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Evaluation of Uracil, Sodium Ascorbate, and Rosiglitazone as Promoters of Urinary Bladder Transitional Cell Carcinomas in Male Sprague-Dawley Rats.
Mark Tirmenstein, Evan Janovitz, Thomas Dorr, Yunling Song, Shen-Jue Chen

Toxicol Pathol· February 2018

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The synthesis of [ C]4-acetylphenylalanine, effect on cell viability, and assessment of protein incorporation in male rat hepatocytes.
Brad D Maxwell, Van Ly, Barry Brock, Robert Dodge, Mark Tirmenstein

J Labelled Comp Radiopharm· June 2017

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Evaluation of microRNAs-208 and 133a/b as differential biomarkers of acute cardiac and skeletal muscle toxicity in rats.
Jacqueline Calvano, William Achanzar, Bethanne Murphy, Janet DiPiero, Clifford Hixson, Mark Tirmenstein

Toxicol Appl Pharmacol· December 2016

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Serum microRNAs-217 and -375 as biomarkers of acute pancreatic injury in rats.
Jacqueline Calvano, Gwendolyn Edwards, Clifford Hixson, Holly Burr, Raja Mangipudy, Mark Tirmenstein

Toxicology· August 2016

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Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.
Mark Tirmenstein, Joseph Horvath, Michael Graziano, Raja Mangipudy, Thomas Dorr

Toxicol Pathol· August 2015

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Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor.
Mark Tirmenstein, Thomas E Dorr, Evan B Janovitz, Deborah Hagan, Lynn M Abell

Int J Toxicol· June 2014

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Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus.
Timothy P Reilly, Michael J Graziano, Evan B Janovitz, Thomas E Dorr, Craig Fairchild, Mark Tirmenstein

Diabetes Ther· June 2014

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Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.
Lindsay Tomlinson, Mark A Tirmenstein, Evan B Janovitz, Nelly Aranibar, Karl-Heinz Ott

Toxicol Sci· October 2012

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Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus.
Jean M Whaley, Mark Tirmenstein, Timothy P Reilly, Simon M Poucher, Joanne Saye

Diabetes Metab Syndr Obes· October 2012

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Targeting renal glucose reabsorption for the treatment of type 2 diabetes mellitus using the SGLT2 inhibitor dapagliflozin.
Serge A Jabbour, Jean M Whaley, Mark Tirmenstein, Simon M Poucher, Timothy P Reilly

Postgrad Med· July 2012

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Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma.
Anne-Françoise Aubry, Huidong Gu, Reynald Magnier, Ling Morgan, Xiaohui Xu, Mark Tirmenstein

Bioanalysis· December 2010

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Effects of 6-hydroxydopamine on mitochondrial function and glutathione status in SH-SY5Y human neuroblastoma cells.
Mark A Tirmenstein, Catherine X Hu, Marshall S Scicchitano, Padma K Narayanan, David C McFarland

Toxicol In Vitro· June 2005

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Effects of troglitazone on HepG2 viability and mitochondrial function.
Mark A Tirmenstein, Catherine X Hu, Tracy L Gales, Beverly E Maleeff, Padma K Narayanan

Toxicol Sci· September 2002

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Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically.
Christine L Merrill, Hong Ni, Lawrence W Yoon, Mark A Tirmenstein, Padma Narayanan

Toxicol Sci· July 2002

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