Publications by authors named "Timothy P Reilly"

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Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma.
Hampartsoum B Barsoumian, Rishab Ramapriyan, Ahmed I Younes, Mauricio S Caetano, Hari Menon, Timothy P Reilly

J Immunother Cancer· October 2020

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Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors.
Kurt A Schalper, Michael Carleton, Ming Zhou, Tian Chen, Ye Feng, Timothy P Reilly

Nat Med· May 2020

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Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses.
Mauricio S Caetano, Ahmed I Younes, Hampartsoum B Barsoumian, Michael Quigley, Hari Menon, Timothy P Reilly

Clin Cancer Res· December 2019

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The Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) program: innovative, high-throughput clinical screening of immunotherapies.
Katy L Simonsen, Paula M Fracasso, Steven H Bernstein, Megan Wind-Rotolo, Manish Gupta, Timothy P Reilly

Eur J Cancer· November 2018

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Assessing Bladder Cancer Risk in Type 2 Diabetes Clinical Trials: the Dapagliflozin Drug Development Program as a 'Case Study'.
Agata Ptaszynska, Samuel M Cohen, Edward M Messing, Timothy P Reilly, Eva Johnsson

Diabetes Ther· September 2015

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Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.
Mala Chakraborty, Aaron M Fullerton, Kenrick Semple, Lynette S Chea, William R Proctor, Timothy P Reilly

Hepatology· August 2015

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Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.
Mark Tirmenstein, Joseph Horvath, Michael Graziano, Raja Mangipudy, Thomas Dorr, Timothy P Reilly

Toxicol Pathol· August 2015

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Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding.
Brittany V Martin-Murphy, Qiang You, Hong Wang, Becky A De La Houssaye, Timothy P Reilly

PLoS One· December 2014

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Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor.
Mark Tirmenstein, Thomas E Dorr, Evan B Janovitz, Deborah Hagan, Lynn M Abell, Timothy P Reilly

Int J Toxicol· June 2014

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Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus.
Timothy P Reilly, Michael J Graziano, Evan B Janovitz, Thomas E Dorr, Craig Fairchild

Diabetes Ther· June 2014

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Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.
Kristina D Chadwick, Anthony M Fletcher, M Cecilia Parrula, Susan Bonner-Weir, Raja S Mangipudy, Timothy P Reilly

Diabetes· April 2014

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Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus.
Jean M Whaley, Mark Tirmenstein, Timothy P Reilly, Simon M Poucher, Joanne Saye

Diabetes Metab Syndr Obes· October 2012

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Targeting renal glucose reabsorption for the treatment of type 2 diabetes mellitus using the SGLT2 inhibitor dapagliflozin.
Serge A Jabbour, Jean M Whaley, Mark Tirmenstein, Simon M Poucher, Timothy P Reilly

Postgrad Med· July 2012

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Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential.
Lloyd LeCureux, Charles S Cheng, John Herbst, Timothy P Reilly, Lois Lehman-McKeeman

Toxicol In Vitro· December 2011

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Evaluation of immunogenicity of the T cell costimulation modulator abatacept in patients treated for rheumatoid arthritis.
Helen G Haggerty, Mark A Abbott, Timothy P Reilly, Deborah A DeVona, Carol R Gleason

J Rheumatol· December 2007

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Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Mohammed Bourdi, Daniel P Eiras, Michael P Holt, Marie R Webster, Timothy P Reilly

Chem Res Toxicol· February 2007

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Role of neutrophils in a mouse model of halothane-induced liver injury.
Qiang You, Linling Cheng, Timothy P Reilly, Dale Wegmann, Cynthia Ju

Hepatology· December 2006

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Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.
James P Luyendyk, Lois D Lehman-McKeeman, David M Nelson, Vasanthi M Bhaskaran, Timothy P Reilly

J Pharmacol Exp Ther· May 2006

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Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.
James P Luyendyk, Lois D Lehman-McKeeman, David M Nelson, Vasanthi M Bhaskaran, Timothy P Reilly

Toxicol Sci· April 2006

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Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.
Kevin D Welch, Timothy P Reilly, Mohammed Bourdi, Thomas Hays, Cynthia A Pise-Masison

Chem Res Toxicol· February 2006

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Characterization of the formation and localization of sulfamethoxazole and dapsone-associated drug-protein adducts in human epidermal keratinocytes.
Sanjoy Roychowdhury, Piyush M Vyas, Timothy P Reilly, Anthony A Gaspari, Craig K Svensson

J Pharmacol Exp Ther· July 2005

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Proteomic identification of potential susceptibility factors in drug-induced liver disease.
Kevin D Welch, Bo Wen, David R Goodlett, Eugene C Yi, Hookeun Lee, Timothy P Reilly

Chem Res Toxicol· June 2005

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Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease.
Yasuhiro Masubuchi, Mohammed Bourdi, Timothy P Reilly, Mary Louise M Graf, John W George

Biochem Biophys Res Commun· April 2003

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Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.
Cynthia Ju, Timothy P Reilly, Mohammed Bourdi, Michael F Radonovich, John N Brady

Chem Res Toxicol· December 2002

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Mechanistic perspectives on sulfonamide-induced cutaneous drug reactions.
Timothy P Reilly, Cynthia Ju

Curr Opin Allergy Clin Immunol· August 2002

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