Publications by authors named "Phil Alper"

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Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.
Phil Alper, Claudia Betschart, Cédric André, Thomas Boulay, Dai Cheng

ACS Med Chem Lett· August 2023

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Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Phil B Alper, Jonathan Deane, Claudia Betschart, David Buffet, Géraldine Collignon Zipfel

Bioorg Med Chem Lett· September 2020

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Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
Thomas Knoepfel, Pierre Nimsgern, Sébastien Jacquier, Marjorie Bourrel, Eric Vangrevelinghe, Phil B Alper

J Med Chem· August 2020

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Photoinduced Rearrangement of Dienones and Santonin Rerouted by Amines.
Zhipeng Zhang, Maxim Ratnikov, Glen Spraggon, Phil B Alper

Angew Chem Int Ed Engl· January 2018

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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
David C Tully, Paul V Rucker, Donatella Chianelli, Jennifer Williams, Agnès Vidal, Phil B Alper

J Med Chem· December 2017

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Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.
Mihai Azimioara, Phil Alper, Christopher Cow, Daniel Mutnick, Victor Nikulin

Bioorg Med Chem Lett· December 2014

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Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
Phil Alper, Mihai Azimioara, Christopher Cow, Daniel Mutnick, Victor Nikulin

Bioorg Med Chem Lett· May 2014

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Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.
Phil B Alper, Thomas H Marsilje, Daniel Mutnick, Wenshuo Lu, Arnab Chatterjee

Bioorg Med Chem Lett· October 2008

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Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold.
Thomas H Marsilje, Phil B Alper, Wenshuo Lu, Daniel Mutnick, Pierre-Yves Michellys

Bioorg Med Chem Lett· October 2008

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Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.
David C Tully, Hong Liu, Arnab K Chatterjee, Phil B Alper, Robert Epple

Bioorg Med Chem Lett· October 2006

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Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors.
David C Tully, Hong Liu, Arnab K Chatterjee, Phil B Alper, Jennifer A Williams

Bioorg Med Chem Lett· October 2006

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Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3.
David C Tully, Hong Liu, Phil B Alper, Arnab K Chatterjee, Robert Epple

Bioorg Med Chem Lett· April 2006

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Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1.
Hong Liu, David C Tully, Robert Epple, Badry Bursulaya, Jun Li, Phil B Alper

Bioorg Med Chem Lett· November 2005

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Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate.
Phil B Alper, KhanhLinh T Nguyen

J Org Chem· March 2003

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