Publications by authors named "Daniel Mutnick"

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Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.
Phil Alper, Claudia Betschart, Cédric André, Thomas Boulay, Dai Cheng, Daniel Mutnick

ACS Med Chem Lett· August 2023

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Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Phil B Alper, Jonathan Deane, Claudia Betschart, David Buffet, Géraldine Collignon Zipfel, Daniel Mutnick

Bioorg Med Chem Lett· September 2020

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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
Colin K Skepper, Duncan Armstrong, Carl J Balibar, Daniel Bauer, Cornelia Bellamacina, Daniel Mutnick

J Med Chem· July 2020

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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
David C Tully, Paul V Rucker, Donatella Chianelli, Jennifer Williams, Agnès Vidal, Daniel Mutnick

J Med Chem· December 2017

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Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.
Mihai Azimioara, Phil Alper, Christopher Cow, Daniel Mutnick, Victor Nikulin

Bioorg Med Chem Lett· December 2014

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Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
Phil Alper, Mihai Azimioara, Christopher Cow, Daniel Mutnick, Victor Nikulin

Bioorg Med Chem Lett· May 2014

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Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.
Julie A Pigza, Jeong-Seok Han, Aroop Chandra, Daniel Mutnick, Maren Pink

J Org Chem· February 2013

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Total synthesis of the lycopodium alkaloid (+)-serratezomine A.
Aroop Chandra, Julie A Pigza, Jeong-Seok Han, Daniel Mutnick, Jeffrey N Johnston

J Am Chem Soc· March 2009

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Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.
Phil B Alper, Thomas H Marsilje, Daniel Mutnick, Wenshuo Lu, Arnab Chatterjee

Bioorg Med Chem Lett· October 2008

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Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold.
Thomas H Marsilje, Phil B Alper, Wenshuo Lu, Daniel Mutnick, Pierre-Yves Michellys

Bioorg Med Chem Lett· October 2008

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Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors.
David C Tully, Hong Liu, Arnab K Chatterjee, Phil B Alper, Jennifer A Williams, Daniel Mutnick

Bioorg Med Chem Lett· October 2006

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The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements.
Rajesh Viswanathan, Daniel Mutnick, Jeffrey N Johnston

J Am Chem Soc· June 2003

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