Publications by authors named "Philip Ruzycki"

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Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development.
Ismael Hernández-Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy Hoffmann, Philip A Ruzycki

PLoS Biol· August 2025

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Autophagy Regulates Müller Glial Cell Inflammatory Activation.
Teresa A Doggett, Zhenqing Zhou, Sohini Rebba, Jacqueline Unsinger, Philip A Ruzycki

Invest Ophthalmol Vis Sci· August 2025

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Molecular mechanism establishing the OFF pathway in vision.
Florentina Soto, Chin-I Lin, Andrew Jo, Ssu-Yu Chou, Ellen G Harding, Philip A Ruzycki

Nat Commun· April 2025

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Compositional variation in eye-infiltrating immune cells distinguishes human uveitis subtypes.
Christian Concepcion, Yu Xia, Yulia Korshunova, Gregory W Bligard, Amal Taylor, Philip A Ruzycki

iScience· March 2025

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A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina.
Ning Shen, Michael J Fitzpatrick, Ellen G Harding, Sohini Rebba, Philip A Ruzycki

bioRxiv· March 2025

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Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development.
Ismael Hernández-Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy Hoffman, Philip A Ruzycki

bioRxiv· February 2025

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Age-related dysregulation of the retinal transcriptome in African turquoise killifish.
Steven Bergmans, Nicole C L Noel, Luca Masin, Ellen G Harding, Aleksandra M Krzywańska, Philip A Ruzycki

Aging Cell· August 2024

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Mucosal signatures of pathogenic T cells in HLA-B*27+ anterior uveitis and axial spondyloarthritis.
Michael A Paley, Xinbo Yang, Lynn M Hassman, Frank Penkava, Lee I Garner, Philip A Ruzycki

JCI Insight· July 2024

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Age-related dysregulation of the retinal transcriptome in African turquoise killifish.
Steven Bergmans, Nicole C L Noel, Luca Masin, Ellen G Harding, Aleksandra M Krzywańska, Philip A Ruzycki

bioRxiv· March 2024

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Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function.
Tae Jun Lee, Yo Sasaki, Philip A Ruzycki, Norimitsu Ban, Joseph B Lin

JCI Insight· January 2024

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Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration.
Joseph B Lin, Andrea Santeford, Jason J Colasanti, Yoon Lee, Aaditya V Shah, Philip A Ruzycki

Cell Rep Med· January 2024

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A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.
Yuefang Zhou, Thomas M Bennett, Philip A Ruzycki, Zhaohua Guo, Yu-Qing Cao

Cells· January 2024

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Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
Charles W Pfeifer, James T Walsh, Andrea Santeford, Joseph B Lin, Wandy L Beatty, Philip A Ruzycki

Proc Natl Acad Sci U S A· November 2023

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Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms.
Yiqiao Zheng, Chi Sun, Xiaodong Zhang, Philip A Ruzycki, Shiming Chen

Elife· November 2023

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Cell-specific Systemic Immune Signatures Associated with Treatment Burden in Neovascular Age-related Macular Degeneration.
Joseph B Lin, Andrea Santeford, Darksha Usmani, Aaditya V Shah, Philip A Ruzycki

Ophthalmol Sci· October 2023

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Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity.
Chi Sun, Philip A Ruzycki, Shiming Chen

Sci Rep· August 2023

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Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms.
Yiqiao Zheng, Chi Sun, Xiaodong Zhang, Philip A Ruzycki, Shiming Chen

bioRxiv· June 2023

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Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis.
Joseph B Lin, Xiaolei Shen, Charles W Pfeifer, Fion Shiau, Andrea Santeford, Philip A Ruzycki

Proc Natl Acad Sci U S A· January 2023

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Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance.
Chi Sun, Xiaodong Zhang, Philip A Ruzycki, Shiming Chen

Front Cell Dev Biol· February 2022

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A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.
Fion Shiau, Philip A Ruzycki, Brian S Clark

Dev Biol· October 2021

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Mutation of the EPHA2 Tyrosine-Kinase Domain Dysregulates Cell Pattern Formation and Cytoskeletal Gene Expression in the Lens.
Yuefang Zhou, Thomas M Bennett, Philip A Ruzycki, Alan Shiels

Cells· September 2021

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Loss of with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages.
Andrea Santeford, Aaron Y Lee, Abdoulaye Sene, Lynn M Hassman, Alexey A Sergushichev, Philip A Ruzycki

Elife· August 2021

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Clinicomolecular Identification of Conserved and Individualized Features of Granulomatous Uveitis.
Lynn M Hassman, Michael A Paley, Ekaterina Esaulova, Grace L Paley, Philip A Ruzycki

Ophthalmol Sci· March 2021

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Atoh7-independent specification of retinal ganglion cell identity.
Justin Brodie-Kommit, Brian S Clark, Qing Shi, Fion Shiau, Dong Won Kim, Philip A Ruzycki

Sci Adv· March 2021

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Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.
Thomas A Ray, Kelly Cochran, Chris Kozlowski, Jingjing Wang, Graham Alexander, Philip A Ruzycki

Nat Commun· July 2020

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