Publications by authors named "Pius Loetscher"

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Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.
Gebhard Thoma, Wolfgang Miltz, Rudolf Waelchli, David Orain, Carsten Spanka, Pius Loetscher

J Med Chem· February 2025

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Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy.
Stuart Hawtin, Cédric André, Géraldine Collignon-Zipfel, Simone Appenzeller, Bettina Bannert, Pius Loetscher

Cell Rep Med· May 2023

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Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.
Thomas Hoyler, Bettina Bannert, Cédric André, Damian Beck, Thomas Boulay, Pius Loetscher

JCI Insight· July 2022

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Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an Efficacious TLR7/8 Antagonist.
Claudia Betschart, Michael Faller, Florence Zink, René Hemmig, Jutta Blank, Pius Loetscher

ACS Med Chem Lett· April 2022

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Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A Hydrolase.
Christian Markert, Gebhard Thoma, Honnappa Srinivas, Birgit Bollbuck, Rainer M Lüönd, Pius Loetscher

J Med Chem· February 2021

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Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
Thomas Knoepfel, Pierre Nimsgern, Sébastien Jacquier, Marjorie Bourrel, Eric Vangrevelinghe, Pius Loetscher

J Med Chem· August 2020

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The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.
Elizabeth A Krewson, Edward J Sanderlin, Mona A Marie, Shayan Nik Akhtar, Juraj Velcicky, Pius Loetscher

iScience· February 2020

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Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.
Edward J Sanderlin, Mona Marie, Juraj Velcicky, Pius Loetscher, Li V Yang

Eur J Pharmacol· June 2019

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Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.
Wolfgang Miltz, Juraj Velcicky, Janet Dawson, Amanda Littlewood-Evans, Marie-Gabrielle Ludwig, Pius Loetscher

Bioorg Med Chem· August 2017

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Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.
Juraj Velcicky, Wolfgang Miltz, Berndt Oberhauser, David Orain, Andrea Vaupel, Pius Loetscher

J Med Chem· May 2017

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Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.
Michail S Lionakis, Nathaniel D Albert, Muthulekha Swamydas, Chyi-Chia R Lee, Pius Loetscher

Antimicrob Agents Chemother· March 2017

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CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.
Alexandre Bignon, Françoise Gaudin, Patrice Hémon, Hugo Tharinger, Katia Mayol, Pius Loetscher

J Immunol· February 2014

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Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.
Takanori Kitamura, Teruaki Fujishita, Pius Loetscher, Laszlo Revesz, Hiroki Hashida

Proc Natl Acad Sci U S A· July 2010

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Microinjection of Cre recombinase protein into zygotes enables specific deletion of two eukaryotic selection cassettes and enhances the expression of a DsRed2 reporter gene in Ccr2/Ccr5 double-deficient mice.
Bruno Luckow, Amy Hänggli, Holger Maier, Silvia Chilla, Robert P Loewe, Pius Loetscher

Genesis· August 2009

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The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.
Volha Ninichuk, Alexander G Khandoga, Stephan Segerer, Pius Loetscher, Achim Schlapbach

Am J Pathol· April 2007

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A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis.
Jasper J Haringman, Danielle M Gerlag, Tom J M Smeets, Dominique Baeten, Filip van den Bosch, Pius Loetscher

Arthritis Rheum· August 2006

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Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.
Laszlo Revesz, Birgit Bollbuck, Thomas Buhl, Joerg Eder, Ronald Esser, Pius Loetscher

Bioorg Med Chem Lett· December 2005

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Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor.
Urs O Gilli, Mårten K J Schneider, Pius Loetscher, Jörg D Seebach

Transplantation· May 2005

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A skin-selective homing mechanism for human immune surveillance T cells.
Patrick Schaerli, Lisa Ebert, Katharina Willimann, Andrea Blaser, Regula Stuber Roos, Pius Loetscher

J Exp Med· May 2004

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Chemokines: multiple levels of leukocyte migration control.
Bernhard Moser, Marlene Wolf, Alfred Walz, Pius Loetscher

Trends Immunol· February 2004

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Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes.
Giuseppe Bardi, Verena Niggli, Pius Loetscher

FEBS Lett· May 2003

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Structure-function relationship between the human chemokine receptor CXCR3 and its ligands.
Ian Clark-Lewis, Ivan Mattioli, Jiang-Hong Gong, Pius Loetscher

J Biol Chem· January 2003

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Homing chemokines in rheumatoid arthritis.
Pius Loetscher, Bernhard Moser

Arthritis Res· December 2002

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CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses.
Bernhard Moser, Patrick Schaerli, Pius Loetscher

Trends Immunol· May 2002

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