Publications by authors named "Poller Birk"

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Evaluation of various experimental conditions and mechanistic static versus dynamic models to predict time-dependent CYP3A4/5 inhibition potential of drugs.
Badée Justine, Gu Helen, Huth Felix, Poller Birk, Schiller Hilmar

Drug Metab Dispos· August 2025

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Drug-induced cholestasis (DIC) predictions based on in vitro inhibition of major bile acid clearance mechanisms.
Vlasia Kastrinou-Lampou, Raquel Rodríguez-Pérez, Birk Poller, Felix Huth, Heiko S Schadt

Arch Toxicol· January 2025

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Intestinal Cells-on-Chip for Permeability Studies.
Marit Keuper-Navis, Hossein Eslami Amirabadi, Joanne Donkers, Markus Walles, Birk Poller

Micromachines (Basel)· November 2024

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Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC).
Vlasia Kastrinou-Lampou, Raquel Rodríguez-Pérez, Birk Poller, Felix Huth, Zsuzsanna Gáborik

Arch Toxicol· October 2024

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Improving In Vitro-In Vivo Extrapolation of Clearance Using Rat Liver Microsomes for Highly Plasma Protein-Bound Molecules.
Markus Trunzer, Joana Teigão, Felix Huth, Birk Poller, Sandrine Desrayaud

Drug Metab Dispos· April 2024

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LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial.
Christian Loesche, Damien Picard, Benjamin Van Hoorick, Imelda Schuhmann, Petra Jäger, Birk Poller

Clin Transl Sci· February 2024

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The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development.
Marit Keuper-Navis, Markus Walles, Birk Poller, Adam Myszczyszyn, Thomas K van der Made

Pharmacol Res· September 2023

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Absorption, Distribution, Metabolism, and Excretion of [C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies.
Alexander David James, Kenneth Kulmatycki, Birk Poller, Andrea A Romeo, Jan Jaap Van Lier

Drug Metab Dispos· July 2023

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Simplifying the Extended Clearance Concept Classification System (EC3S) to Guide Clearance Prediction in Drug Discovery.
Mitesh Patel, Julia Riede, Dallas Bednarczyk, Birk Poller, Sujal V Deshmukh

Pharm Res· April 2023

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Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes.
Vlasia Kastrinou Lampou, Birk Poller, Felix Huth, Audrey Fischer, Gerd A Kullak-Ublick

Toxicol In Vitro· March 2023

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Human Pharmacokinetics of LYS006, an Oral Leukotriene A4 Hydrolase Inhibitor Displaying Target-Mediated Drug Disposition.
Birk Poller, David Pearson, Luc Alexis Leuthold, Martin Fink, Astrid Jullion

Drug Metab Dispos· December 2022

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Time matters - cellular disposition kinetics help rationalizing cellular potency disconnects.
Birk Poller, Sophie Werner, Norbert Domange, Lina Mettler, Richard R Stein

Xenobiotica· August 2022

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Fevipiprant (QAW039) does not affect the pharmacokinetics of zidovudine, its glucuronide, and penicillin G via inhibition of UGT2B7 and/or OAT3.
Swarupa Kulkarni, Birk Poller, Anton Drollmann, Bharti Shah, Cathy Gray

Pulm Pharmacol Ther· February 2022

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Novel Bruton's Tyrosine Kinase inhibitor remibrutinib: Drug-drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling.
Felix Huth, Hilmar Schiller, Yi Jin, Birk Poller, Carole Schuhler

Clin Transl Sci· January 2022

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Predicting Oral Absorption for Compounds Outside the Rule of Five Property Space.
Felix Huth, Norbert Domange, Birk Poller, Arpine Vapurcuyan, Alexandre Durrwell

J Pharm Sci· June 2021

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Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator.
H Markus Weiss, Thomas Langenickel, Meredith Cain, Swarupa Kulkarni, Bharti Shah, Birk Poller

Drug Metab Dispos· May 2021

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Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.
Birk Poller, Ralph Woessner, Avantika Barve, Hanns-Christian Tillmann, Janardhana Vemula

Pulm Pharmacol Ther· August 2019

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A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters.
Péter Tátrai, Patrick Schweigler, Birk Poller, Norbert Domange, Roelof de Wilde

Drug Metab Dispos· July 2019

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Examining P-gp efflux kinetics guided by the BDDCS - Rational selection of in vitro assay designs and mathematical models.
Julia Riede, Ken-Ichi Umehara, Patrick Schweigler, Felix Huth, Hilmar Schiller, Birk Poller

Eur J Pharm Sci· April 2019

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Current In Vitro Methods to Determine Hepatic Kp: A Comparison of Their Usefulness and Limitations.
Julia Riede, Gian Camenisch, Jörg Huwyler, Birk Poller

J Pharm Sci· September 2017

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Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations.
Julia Riede, Birk Poller, Jörg Huwyler, Gian Camenisch

Drug Metab Dispos· May 2017

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New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.
Julia Riede, Birk Poller, Ken-ichi Umehara, Jörg Huwyler, Gian Camenisch

Eur J Pharm Sci· April 2016

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Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins.
Annett Kunze, Birk Poller, Jörg Huwyler, Gian Camenisch

Drug Metab Pers Ther· September 2015

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Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data.
Annett Kunze, Jörg Huwyler, Gian Camenisch, Birk Poller

Drug Metab Dispos· September 2014

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In vitro-in vivo extrapolation method to predict human renal clearance of drugs.
Annett Kunze, Jörg Huwyler, Birk Poller, Heike Gutmann, Gian Camenisch

J Pharm Sci· March 2014

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