Publications by authors named "Pushkar Kulkarni"

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Inhibition of PSD95-nNOS protein-protein interactions decreases morphine reward and relapse vulnerability in rats.
Idaira Oliva, Shahin A Saberi, Claudia Rangel-Barajas, Vishakh Iyer, Kendra D Bunner, Pushkar M Kulkarni

Addict Biol· September 2022

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A high-specificity aniline-based mass tag for aldehyde detection.
Prisca Mungalachetty, Pushkar Kulkarni, Poguang Wang, Roger Giese

Rapid Commun Mass Spectrom· August 2022

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Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021.
Akshay Sonawane, Bharadwaja Vadloori, Suresh Poosala, Helena Kandarova, Mandar Kulkarni, Pushkar Kulkarni

Altern Lab Anim· March 2022

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A DNAzyme based knockdown model for Fragile-X syndrome in zebrafish reveals a critical window for therapeutic intervention.
Raghavender Medishetti, Rita Rani, Srinivas Kavati, Anjali Mahilkar, Venkateswarlu Akella, Pushkar Kulkarni

J Pharmacol Toxicol Methods· November 2020

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Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility.
Peter C Schaffer, Pushkar M Kulkarni, David R Janero, Ganesh A Thakur

Bioorg Med Chem· November 2020

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Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis.
Christopher R Miller, Somrita Dey, Paula D Smolenski, Pushkar S Kulkarni, Jonathan M Monk

Antimicrob Agents Chemother· February 2020

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Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.
Sumanta Garai, Pushkar M Kulkarni, Peter C Schaffer, Luciana M Leo, Asher L Brandt

J Med Chem· January 2020

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Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation.
Dinesh Thapa, Elizabeth A Cairns, Anna-Maria Szczesniak, Pushkar M Kulkarni, Alex J Straiker

Molecules· January 2020

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Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure-Activity Relationship Studies.
Dow P Hurst, Sumanta Garai, Pushkar M Kulkarni, Peter C Schaffer, Patricia H Reggio

ACS Med Chem Lett· August 2019

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InCl mediated heteroarylation of indoles and their derivatization via CH activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis.
Rajnikanth Sunke, Ramudu Bankala, B Thirupataiah, E V V Shivaji Ramarao, Jetta Sandeep Kumar, Pushkar Kulkarni

Eur J Med Chem· July 2019

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Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model.
Robert B Laprairie, Amina M Bagher, Jillian L Rourke, Adel Zrein, Elizabeth A Cairns, Pushkar M Kulkarni

Neuropharmacology· June 2019

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Larval zebrafish model for studying the effects of valproic acid on neurodevelopment: An approach towards modeling autism.
Shubham Dwivedi, Raghavender Medishetti, Rita Rani, Aarti Sevilimedu, Pushkar Kulkarni

J Pharmacol Toxicol Methods· March 2019

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Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.
Richard A Slivicki, Zhili Xu, Pushkar M Kulkarni, Roger G Pertwee, Ken Mackie

Biol Psychiatry· November 2018

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Magnetic nanoparticle formulation for targeted delivery of chemotherapeutic irinotecan to lungs.
Pushkar Kulkarni, Marina Rajadurai, Aarti Sevilimedu, Surendar Basaveni, Swapna Yellanki

Drug Deliv Transl Res· October 2018

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Correlation of pharmacokinetics and brain penetration data of adult zebrafish with higher mammals including humans.
Pushkar Kulkarni, Raghavender Medishetti, Nagaraju Nune, Swapna Yellanki, Vijaykumar Sripuram

J Pharmacol Toxicol Methods· July 2018

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Enantiomer-specific positive allosteric modulation of CB signaling in autaptic hippocampal neurons.
Jose Mitjavila, Danielle Yin, Pushkar M Kulkarni, Chiara Zanato, Ganesh A Thakur

Pharmacol Res· March 2018

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The In Vivo Effects of the CB-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice.
Elizabeth A Cairns, Anna-Maria Szczesniak, Alex J Straiker, Pushkar M Kulkarni, Roger G Pertwee

J Ocul Pharmacol Ther· October 2017

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Design, Synthesis and Evaluation of 5-pyridin-4-yl-2-thioxo-[1,3,4]oxadiazol-3-yl Derivatives as Anti-angiogenic Agents Targeting VEGFR-2.
Umesh Bhanushali, Samidha Kalekar-Joshi, Renuka Kulkarni-Munshi, Swapna Yellanki, Raghavender Medishetty, Pushkar Kulkarni

Anticancer Agents Med Chem· June 2017

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Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor.
Robert B Laprairie, Pushkar M Kulkarni, Jeffrey R Deschamps, Melanie E M Kelly, David R Janero

ACS Chem Neurosci· June 2017

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Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats.
Lawrence M Carey, Wan-Hung Lee, Tannia Gutierrez, Pushkar M Kulkarni, Ganesh A Thakur

Neuroscience· May 2017

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Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis.
Pushkar Kulkarni, Swapna Yellanki, Raghavender Medishetti, Dharmarajan Sriram, Uday Saxena

Mult Scler Relat Disord· January 2017

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5-Benzylidene-2,4-thiazolidenedione derivatives: Design, synthesis and evaluation as inhibitors of angiogenesis targeting VEGR-2.
Umesh Bhanushali, Saranya Rajendran, Keerthana Sarma, Pushkar Kulkarni, Kiranam Chatti

Bioorg Chem· August 2016

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Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.
Robert B Laprairie, Abhijit R Kulkarni, Pushkar M Kulkarni, Dow P Hurst, Diane Lynch

ACS Chem Neurosci· June 2016

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Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors.
Alexandra E Smith, Zhili Xu, Yvonne Y Lai, Pushkar M Kulkarni, Ganesh A Thakur

Behav Brain Res· May 2016

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Structure-Guided Discovery of Antitubercular Agents That Target the Gyrase ATPase Domain.
Variam U Jeankumar, Shalini Saxena, Rahul Vats, Rudraraju Srilakshmi Reshma, Renuka Janupally, Pushkar Kulkarni

ChemMedChem· March 2016

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