Publications by authors named "Quentin Spillier"

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Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies.
Ferran Nadal-Bufi, Mégane Van Gysel, Chiara Brustenga, Perrine Savoyen, Caroline Mathieu, Quentin Spillier

Protein Sci· December 2025

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Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy.
Guangbin Shi, Claire Miller, Sota Kuno, Alejandro G Rey Hipolito, Salsabiel El Nagar, Quentin Spillier

Nature· September 2025

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Examining Arginase-1 Trimerization Uncovers a Promising Allosteric Site for Inhibition.
Juhans Dechenne, Magdalena Wierzbicka, Reda Krimou, Asia El Aakchioui, Julia Malo Pueyo, Quentin Spillier

J Med Chem· January 2025

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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.
Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Quentin Spillier

J Immunother Cancer· June 2023

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The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway.
Robert S Banh, Esther S Kim, Quentin Spillier, Douglas E Biancur, Keisuke Yamamoto

Nature· September 2021

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Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015-2020.
Quentin Spillier, Raphaël Frédérick

Expert Opin Ther Pat· July 2021

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Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments.
Quentin Spillier, Séverine Ravez, Simon Dochain, Didier Vertommen, Léopold Thabault

Molecules· January 2021

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Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.
Léopold Thabault, Lucie Brisson, Chiara Brustenga, Santiago A Martinez Gache, Julien R C Prévost, Quentin Spillier

J Med Chem· May 2020

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Structure-Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH).
Quentin Spillier, Séverine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre

Pharmaceuticals (Basel)· January 2020

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Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation.
Quentin Spillier, Didier Vertommen, Séverine Ravez, Romain Marteau, Quentin Thémans

Sci Rep· March 2019

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Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy.
Séverine Ravez, Quentin Spillier, Romain Marteau, Olivier Feron, Raphaël Frédérick

J Med Chem· February 2017

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α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).
Séverine Ravez, Cyril Corbet, Quentin Spillier, Alice Dutu, Anita D Robin

J Med Chem· February 2017

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