Publications by authors named "Ralph Alderson"

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A Strategy for Simultaneous Engineering of Interspecies Cross-Reactivity, Thermostability, and Expression of a Bispecific 5T4 x CD3 DART Molecule for Treatment of Solid Tumors.
Renhua R Huang, Michael Spliedt, Tom Kaufman, Sergey Gorlatov, Bhaswati Barat, Ralph Alderson

Antibodies (Basel)· January 2025

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Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer.
Paul A Moore, Kalpana Shah, Yinhua Yang, Ralph Alderson, Penny Roberts

Mol Cancer Ther· August 2018

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Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity.
Olivia Campagne, Audrey Delmas, Sylvain Fouliard, Marylore Chenel, Gurunadh R Chichili, Ralph Alderson

Clin Cancer Res· June 2018

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MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies.
Liqin Liu, Chia-Ying K Lam, Vatana Long, Lusiana Widjaja, Yinhua Yang, Ralph Alderson

Clin Cancer Res· March 2017

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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Adam R Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Ralph Alderson

Antibodies (Basel)· March 2016

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A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates.
Gurunadh R Chichili, Ling Huang, Hua Li, Steve Burke, Leilei He, Ralph Alderson

Sci Transl Med· May 2015

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Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity.
Deryk Loo, Ralph F Alderson, Francine Z Chen, Ling Huang, Wenjun Zhang

Clin Cancer Res· July 2012

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CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies.
Ralph F Alderson, Robert J Kreitman, Tianling Chen, Peter Yeung, Ronald Herbst

Clin Cancer Res· February 2009

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Characterization of a CC49-based single-chain fragment-beta-lactamase fusion protein for antibody-directed enzyme prodrug therapy (ADEPT).
Ralph F Alderson, Brian E Toki, Martin Roberge, Wei Geng, Joshua Basler

Bioconjug Chem· July 2006

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In vitro and in vivo effects of repifermin (keratinocyte growth factor-2, KGF-2) on human carcinoma cells.
Ralph Alderson, Shiva Gohari-Fritsch, Hendrik Olsen, Viktor Roschke, Courtney Vance

Cancer Chemother Pharmacol· September 2002

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Expression of Ciliary Neurotrophic Factor and the Neurotrophins-Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin 3-in Cultured Rat Hippocampal Astrocytes.
John S. Rudge, Ralph F. Alderson, Elizabeth Pasnikowski, Joyce McClain, Nancy Y. Ip

Eur J Neurosci· January 1992

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NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression.
Peter C Maisonpierre, Leonardo Belluscio, Beth Friedman, Ralph F Alderson, Stanley J Wiegand

Neuron· October 1990

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